Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study
This article is part of Josepha Joseph's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/2968 Many incident cases of type 2 diabetes do not fulfill the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this stu...
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Online Access: | https://hdl.handle.net/10037/3626 https://doi.org/10.1007/s10654-010-9540-7 |
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ftunivtroemsoe:oai:munin.uit.no:10037/3626 2023-05-15T18:34:35+02:00 Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study Joseph, Josepha Svartberg, Johan Njølstad, Inger Schirmer, Henrik 2010 https://hdl.handle.net/10037/3626 https://doi.org/10.1007/s10654-010-9540-7 eng eng Springer European journal of epidemiology, vol. 26, number 2, 117-124 doi:10.1007/s10654-010-9540-7 https://hdl.handle.net/10037/3626 URN:NBN:no-uit_munin_3342 openAccess metabolic syndrome low metabolic score high metabolic score non-metabolic risk factors receiver operating characteristics type 2 diabetes VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804 VDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Journal article Tidsskriftartikkel Peer reviewed 2010 ftunivtroemsoe https://doi.org/10.1007/s10654-010-9540-7 2021-06-25T17:53:08Z This article is part of Josepha Joseph's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/2968 Many incident cases of type 2 diabetes do not fulfill the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and who did not have diabetes when entering the study. A total of 492 incident cases of type 2 diabetes were registered. A metabolic score was defined according to a modified version of the National Cholesterol Education Program Adult Treatment Panel III. For those fulfilling C 3 metabolic score criteria, increasing age, body mass index (BMI), triglycerides and a family history of diabetes were independent predictors. Age, BMI, and triglycerides predicted type 2 diabetes more strongly in subjects with low metabolic score, whereas high HDL cholesterol was not protective in this low risk group. The risk associated with a positive family history was unaffected by level of metabolic score. In addition smoking, low education and in men also physical inactivity were independent risk factors only in those with low metabolic score. Adding these nonmetabolic risk factors increased correct classification from an ROC area of 77.2 to 87.1% (P value\0.0001). One half of the incident cases of type 2 diabetes were missed by using high metabolic score for risk prediction Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø European Journal of Epidemiology 26 2 117 124 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
metabolic syndrome low metabolic score high metabolic score non-metabolic risk factors receiver operating characteristics type 2 diabetes VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804 VDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 |
spellingShingle |
metabolic syndrome low metabolic score high metabolic score non-metabolic risk factors receiver operating characteristics type 2 diabetes VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804 VDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Joseph, Josepha Svartberg, Johan Njølstad, Inger Schirmer, Henrik Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study |
topic_facet |
metabolic syndrome low metabolic score high metabolic score non-metabolic risk factors receiver operating characteristics type 2 diabetes VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804 VDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 |
description |
This article is part of Josepha Joseph's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/2968 Many incident cases of type 2 diabetes do not fulfill the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and who did not have diabetes when entering the study. A total of 492 incident cases of type 2 diabetes were registered. A metabolic score was defined according to a modified version of the National Cholesterol Education Program Adult Treatment Panel III. For those fulfilling C 3 metabolic score criteria, increasing age, body mass index (BMI), triglycerides and a family history of diabetes were independent predictors. Age, BMI, and triglycerides predicted type 2 diabetes more strongly in subjects with low metabolic score, whereas high HDL cholesterol was not protective in this low risk group. The risk associated with a positive family history was unaffected by level of metabolic score. In addition smoking, low education and in men also physical inactivity were independent risk factors only in those with low metabolic score. Adding these nonmetabolic risk factors increased correct classification from an ROC area of 77.2 to 87.1% (P value\0.0001). One half of the incident cases of type 2 diabetes were missed by using high metabolic score for risk prediction |
format |
Article in Journal/Newspaper |
author |
Joseph, Josepha Svartberg, Johan Njølstad, Inger Schirmer, Henrik |
author_facet |
Joseph, Josepha Svartberg, Johan Njølstad, Inger Schirmer, Henrik |
author_sort |
Joseph, Josepha |
title |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study |
title_short |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study |
title_full |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study |
title_fullStr |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study |
title_full_unstemmed |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study |
title_sort |
risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of the tromsø study |
publisher |
Springer |
publishDate |
2010 |
url |
https://hdl.handle.net/10037/3626 https://doi.org/10.1007/s10654-010-9540-7 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
European journal of epidemiology, vol. 26, number 2, 117-124 doi:10.1007/s10654-010-9540-7 https://hdl.handle.net/10037/3626 URN:NBN:no-uit_munin_3342 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1007/s10654-010-9540-7 |
container_title |
European Journal of Epidemiology |
container_volume |
26 |
container_issue |
2 |
container_start_page |
117 |
op_container_end_page |
124 |
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1766219379314262016 |