Engineering novel bacterial biosensors for the characterization of membrane active natural products

• Main Author: Richard, Celine Sarah Marine
• Format: Doctoral or Postdoctoral Thesis
• Language: English
• Published: UiT The Arctic University of Norway 2024
• Subjects: Antibiotic resistance; bacterial biosensor; antimicrobial peptide; natural product; drug discovery; reporter gene; membrane; DOKTOR-002; Arctic; Moa
• Online Access: https://hdl.handle.net/10037/33610

Treatment of bacterial infections has become more challenging due to the expansion of antibiotic resistance. Especially, resistant Gram-negative pathogens are burdening healthcare systems worldwide. This increases the need for new antibiotics able to penetrate the outer-membrane (OM) of Gram-negativ...