The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus : Epidemiology, Disease Presentation, and Patient Management
The influence of the 1997 updated classification criteria for systemic lupus erythematosus: epidemiology, disease presentation, and patient management. Eilertsen GØ, Becker-Merok A, Nossent JC. Department of Rheumatology, Medical School, University of Tromsø, 9037 Tromsø, Norway. gro.ostli.eilertsen...
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Online Access: | https://hdl.handle.net/10037/3282 https://doi.org/10.3899/jrheum.080574 |
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ftunivtroemsoe:oai:munin.uit.no:10037/3282 2024-06-02T08:12:05+00:00 The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus : Epidemiology, Disease Presentation, and Patient Management Eilertsen, Gro Østli Becker-Merok, Andrea Nossent, Johannes C 2009 https://hdl.handle.net/10037/3282 https://doi.org/10.3899/jrheum.080574 eng eng The Journal of Rheumatology Journal of Rheumatology 36(2009) nr. 3 s. 552-559 FRIDAID 345119 doi:10.3899/jrheum.080574 0315-162X https://hdl.handle.net/10037/3282 URN:NBN:no-uit_munin_3013 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Rheumatology: 759 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759 Journal article Tidsskriftartikkel Peer reviewed 2009 ftunivtroemsoe https://doi.org/10.3899/jrheum.080574 2024-05-07T08:42:34Z The influence of the 1997 updated classification criteria for systemic lupus erythematosus: epidemiology, disease presentation, and patient management. Eilertsen GØ, Becker-Merok A, Nossent JC. Department of Rheumatology, Medical School, University of Tromsø, 9037 Tromsø, Norway. gro.ostli.eilertsen@unn.no OBJECTIVE: The 1997 update of the American College of Rheumatology classification criteria (ACR97) for systemic lupus erythematosus (SLE) has not been validated. We determined to what extent their introduction influenced the epidemiology and clinical characteristics of the disease in northern Norway. METHODS: Annual incidence and point-prevalence rates, clinical manifestations, and outcome were determined in an inception cohort of patients with SLE in northern Norway, included between 1996 and 2006, using ACR97 criteria (97acr). These findings were compared with a cohort from the same area enrolled 1978-1995 using the 1982 revised criteria ACR82 (82acr). RESULTS: The mean annual incidence of SLE was 3.00 for cohort 97acr (n = 58) versus 2.63 for cohort 82acr (n = 81) (p = 0.5). All patients in the 97acr cohort also fulfilled the 1982 criteria; however, significantly fewer patients presented with discoid rash [odds ratio (OR) 0.31)], arthritis (OR 0.24), renal (OR 0.28) or hematological disorder (OR 0.27), and significantly more with anti-dsDNA (OR 2.57) and antiphospholipid antibodies (OR 27.9). Initial treatment with intravenous pulse methylprednisolone (OR 9.23), azathioprine (OR 6.32), and low-dose aspirin (OR 20.9) was increased in cohort 97acr. Five- (95.2%) and 10-year survival (91.9%) rates were also improved for cohort 97acr. CONCLUSION: The ACR97 criteria set has construct validity compared to the ACR82 criteria set. SLE incidence remains unchanged in northern Norway, but a significant reduction of renal disease and further improvements in survival rates occurred simultaneously with increased serological surveillance with ELISA-based assays and early immunosuppressive and anticoagulant therapy. Article in Journal/Newspaper Northern Norway University of Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø The Journal of Rheumatology 36 3 552 559 |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Rheumatology: 759 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Rheumatology: 759 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759 Eilertsen, Gro Østli Becker-Merok, Andrea Nossent, Johannes C The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus : Epidemiology, Disease Presentation, and Patient Management |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Rheumatology: 759 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759 |
description |
The influence of the 1997 updated classification criteria for systemic lupus erythematosus: epidemiology, disease presentation, and patient management. Eilertsen GØ, Becker-Merok A, Nossent JC. Department of Rheumatology, Medical School, University of Tromsø, 9037 Tromsø, Norway. gro.ostli.eilertsen@unn.no OBJECTIVE: The 1997 update of the American College of Rheumatology classification criteria (ACR97) for systemic lupus erythematosus (SLE) has not been validated. We determined to what extent their introduction influenced the epidemiology and clinical characteristics of the disease in northern Norway. METHODS: Annual incidence and point-prevalence rates, clinical manifestations, and outcome were determined in an inception cohort of patients with SLE in northern Norway, included between 1996 and 2006, using ACR97 criteria (97acr). These findings were compared with a cohort from the same area enrolled 1978-1995 using the 1982 revised criteria ACR82 (82acr). RESULTS: The mean annual incidence of SLE was 3.00 for cohort 97acr (n = 58) versus 2.63 for cohort 82acr (n = 81) (p = 0.5). All patients in the 97acr cohort also fulfilled the 1982 criteria; however, significantly fewer patients presented with discoid rash [odds ratio (OR) 0.31)], arthritis (OR 0.24), renal (OR 0.28) or hematological disorder (OR 0.27), and significantly more with anti-dsDNA (OR 2.57) and antiphospholipid antibodies (OR 27.9). Initial treatment with intravenous pulse methylprednisolone (OR 9.23), azathioprine (OR 6.32), and low-dose aspirin (OR 20.9) was increased in cohort 97acr. Five- (95.2%) and 10-year survival (91.9%) rates were also improved for cohort 97acr. CONCLUSION: The ACR97 criteria set has construct validity compared to the ACR82 criteria set. SLE incidence remains unchanged in northern Norway, but a significant reduction of renal disease and further improvements in survival rates occurred simultaneously with increased serological surveillance with ELISA-based assays and early immunosuppressive and anticoagulant therapy. |
format |
Article in Journal/Newspaper |
author |
Eilertsen, Gro Østli Becker-Merok, Andrea Nossent, Johannes C |
author_facet |
Eilertsen, Gro Østli Becker-Merok, Andrea Nossent, Johannes C |
author_sort |
Eilertsen, Gro Østli |
title |
The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus : Epidemiology, Disease Presentation, and Patient Management |
title_short |
The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus : Epidemiology, Disease Presentation, and Patient Management |
title_full |
The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus : Epidemiology, Disease Presentation, and Patient Management |
title_fullStr |
The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus : Epidemiology, Disease Presentation, and Patient Management |
title_full_unstemmed |
The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus : Epidemiology, Disease Presentation, and Patient Management |
title_sort |
influence of the 1997 updated classification criteria for systemic lupus erythematosus : epidemiology, disease presentation, and patient management |
publisher |
The Journal of Rheumatology |
publishDate |
2009 |
url |
https://hdl.handle.net/10037/3282 https://doi.org/10.3899/jrheum.080574 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Northern Norway University of Tromsø |
genre_facet |
Northern Norway University of Tromsø |
op_relation |
Journal of Rheumatology 36(2009) nr. 3 s. 552-559 FRIDAID 345119 doi:10.3899/jrheum.080574 0315-162X https://hdl.handle.net/10037/3282 URN:NBN:no-uit_munin_3013 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.3899/jrheum.080574 |
container_title |
The Journal of Rheumatology |
container_volume |
36 |
container_issue |
3 |
container_start_page |
552 |
op_container_end_page |
559 |
_version_ |
1800758408303869952 |