Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014
Objective - To examine the dose-response association between estimated cardiorespiratory fitness (eCRF) and risk of myocardial infarction (MI). Patients and Methods - Adults who attended Tromsø Study surveys 4-6 (Janurary 1,1994-December 20, 2008) with no previous cardiovascular disease were followe...
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Online Access: | https://hdl.handle.net/10037/32361 https://doi.org/10.1016/j.mayocpiqo.2023.12.007 |
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ftunivtroemsoe:oai:munin.uit.no:10037/32361 2024-02-04T10:05:00+01:00 Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014 Sagelv, Edvard Hamnvik Casolo, Andrea Eggen, Anne Elise Heitmann, Kim Arne Johansen, Kristoffer Robin Løchen, Maja-Lisa Mathiesen, Ellisiv B. Morseth, Bente Njølstad, Inger Osborne, John Owen Hagerupsen, Karianne Pedersen, Sigurd Wilsgaard, Tom 2024-01-06 https://hdl.handle.net/10037/32361 https://doi.org/10.1016/j.mayocpiqo.2023.12.007 eng eng Elsevier Mayo Clinic Proceedings: Innovations, Quality & Outcomes (MCP:IQ&O) https://www.mcpiqojournal.org/action/showPdf?pii=S2542-4548%2823%2900082-6 Sagelv EH, Casolo A, Eggen AE, Heitmann KA, Johansen KR, Løchen M, Mathiesen EB, Morseth B, Njølstad i, Osborne J, Hagerupsen K, Pedersen S, Wilsgaard T. Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014. Mayo Clinic Proceedings: Innovations, Quality & Outcomes (MCP:IQ&O). 2023 FRIDAID 2220875 doi:10.1016/j.mayocpiqo.2023.12.007 2542-4548 https://hdl.handle.net/10037/32361 Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2023 The Author(s) https://creativecommons.org/licenses/by/4.0 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2024 ftunivtroemsoe https://doi.org/10.1016/j.mayocpiqo.2023.12.007 2024-01-11T00:08:07Z Objective - To examine the dose-response association between estimated cardiorespiratory fitness (eCRF) and risk of myocardial infarction (MI). Patients and Methods - Adults who attended Tromsø Study surveys 4-6 (Janurary 1,1994-December 20, 2008) with no previous cardiovascular disease were followed up through December 31, 2014 for incident MI. Associations were examined using restricted cubic splines Fine and Gray regressions, adjusted for education, smoking, alcohol, diet, sex, adiposity, physical activity, study survey, and age (timescale) in the total cohort and subsamples with hyperlipidemia (n=2956), hypertension (n=8290), obesity (n=5784), metabolic syndrome (n=1410), smokers (n=3823), and poor diet (n=3463) and in those who were physically inactive (n=6255). Results - Of 14,285 participants (mean age ± SD, 53.7±11.4 years), 979 (6.9%) experienced MI during follow-up (median, 7.2 years; 25th-75th, 5.3-14.6 years). Females with median eCRF (32 mL/kg/min) had 43% lower MI risk (subdistributed hazard ratio [SHR], 0.57; 95% CI, 0.48-0.68) than those at the 10th percentile (25 mL/kg/min) as reference. The lowest MI risk was observed at 47 mL/kg/min (SHR, 0.02; 95% CI, 0.01-0.11). Males had 26% lower MI risk at median eCRF (40 mL/kg/min; SHR, 0.74; 95% CI, 0.63-0.86) than those at the 10th percentile (32 mL/kg/min), and the lowest risk was 69% (SHR, 0.31; 95% CI, 0.14-0.71) at 60 mL/kg/min. The associations were similar in subsamples with cardiovascular disease risk factors. Conclusion - Higher eCRF associated with lower MI risk in females and males, but associations were more pronounced among females than those in males. This suggest eCRF as a vital estimate to implement in medical care to identify individuals at high risk of future MI, especially for females. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Mayo Clinic Proceedings: Innovations, Quality & Outcomes 8 1 62 73 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
description |
Objective - To examine the dose-response association between estimated cardiorespiratory fitness (eCRF) and risk of myocardial infarction (MI). Patients and Methods - Adults who attended Tromsø Study surveys 4-6 (Janurary 1,1994-December 20, 2008) with no previous cardiovascular disease were followed up through December 31, 2014 for incident MI. Associations were examined using restricted cubic splines Fine and Gray regressions, adjusted for education, smoking, alcohol, diet, sex, adiposity, physical activity, study survey, and age (timescale) in the total cohort and subsamples with hyperlipidemia (n=2956), hypertension (n=8290), obesity (n=5784), metabolic syndrome (n=1410), smokers (n=3823), and poor diet (n=3463) and in those who were physically inactive (n=6255). Results - Of 14,285 participants (mean age ± SD, 53.7±11.4 years), 979 (6.9%) experienced MI during follow-up (median, 7.2 years; 25th-75th, 5.3-14.6 years). Females with median eCRF (32 mL/kg/min) had 43% lower MI risk (subdistributed hazard ratio [SHR], 0.57; 95% CI, 0.48-0.68) than those at the 10th percentile (25 mL/kg/min) as reference. The lowest MI risk was observed at 47 mL/kg/min (SHR, 0.02; 95% CI, 0.01-0.11). Males had 26% lower MI risk at median eCRF (40 mL/kg/min; SHR, 0.74; 95% CI, 0.63-0.86) than those at the 10th percentile (32 mL/kg/min), and the lowest risk was 69% (SHR, 0.31; 95% CI, 0.14-0.71) at 60 mL/kg/min. The associations were similar in subsamples with cardiovascular disease risk factors. Conclusion - Higher eCRF associated with lower MI risk in females and males, but associations were more pronounced among females than those in males. This suggest eCRF as a vital estimate to implement in medical care to identify individuals at high risk of future MI, especially for females. |
format |
Article in Journal/Newspaper |
author |
Sagelv, Edvard Hamnvik Casolo, Andrea Eggen, Anne Elise Heitmann, Kim Arne Johansen, Kristoffer Robin Løchen, Maja-Lisa Mathiesen, Ellisiv B. Morseth, Bente Njølstad, Inger Osborne, John Owen Hagerupsen, Karianne Pedersen, Sigurd Wilsgaard, Tom |
spellingShingle |
Sagelv, Edvard Hamnvik Casolo, Andrea Eggen, Anne Elise Heitmann, Kim Arne Johansen, Kristoffer Robin Løchen, Maja-Lisa Mathiesen, Ellisiv B. Morseth, Bente Njølstad, Inger Osborne, John Owen Hagerupsen, Karianne Pedersen, Sigurd Wilsgaard, Tom Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014 |
author_facet |
Sagelv, Edvard Hamnvik Casolo, Andrea Eggen, Anne Elise Heitmann, Kim Arne Johansen, Kristoffer Robin Løchen, Maja-Lisa Mathiesen, Ellisiv B. Morseth, Bente Njølstad, Inger Osborne, John Owen Hagerupsen, Karianne Pedersen, Sigurd Wilsgaard, Tom |
author_sort |
Sagelv, Edvard Hamnvik |
title |
Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014 |
title_short |
Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014 |
title_full |
Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014 |
title_fullStr |
Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014 |
title_full_unstemmed |
Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014 |
title_sort |
females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. the tromsø study 1994-2014 |
publisher |
Elsevier |
publishDate |
2024 |
url |
https://hdl.handle.net/10037/32361 https://doi.org/10.1016/j.mayocpiqo.2023.12.007 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Mayo Clinic Proceedings: Innovations, Quality & Outcomes (MCP:IQ&O) https://www.mcpiqojournal.org/action/showPdf?pii=S2542-4548%2823%2900082-6 Sagelv EH, Casolo A, Eggen AE, Heitmann KA, Johansen KR, Løchen M, Mathiesen EB, Morseth B, Njølstad i, Osborne J, Hagerupsen K, Pedersen S, Wilsgaard T. Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014. Mayo Clinic Proceedings: Innovations, Quality & Outcomes (MCP:IQ&O). 2023 FRIDAID 2220875 doi:10.1016/j.mayocpiqo.2023.12.007 2542-4548 https://hdl.handle.net/10037/32361 |
op_rights |
Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2023 The Author(s) https://creativecommons.org/licenses/by/4.0 |
op_doi |
https://doi.org/10.1016/j.mayocpiqo.2023.12.007 |
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