Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015
Summary In the last century, there has been a dramatic increase in chemical production and number and diversity of chemicals produced. Especially, organofluorine chemistry has increased its importance due to applications in pharmaceuticals, agrochemicals, refrigerant gases and in consumer products a...
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UiT The Arctic University of Norway
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ftunivtroemsoe:oai:munin.uit.no:10037/31818 2023-12-17T10:51:07+01:00 Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015 Cioni, Lara 2023-12-06 https://hdl.handle.net/10037/31818 eng eng UiT The Arctic University of Norway UiT Norges arktiske universitet Paper 1: Cioni, L., Nikiforov, V., Coêlho, A.C.M.F., Sandanger, T.M. & Herzke, D. (2022). Total oxidizable precursors assay for PFAS in human serum. Environment International, 170 , 107656. Also available in Munin at https://hdl.handle.net/10037/27580 . Paper 2: Cioni, L., Plassmann, M.M., Benskin, J.P., Coêlho, A.C.M.F., Nøst, T.H., Rylander, C., Nikiforov, V., Sandanger, T.M. & Herzke D. Fluorine mass balance, including total fluorine, extractable organic fluorine, oxidizable precursors and target PFAS, in pooled human serum from the Tromsø population in 1986, 2007 and 2015. (Accepted manuscript). Now published in Environmental Science and Technology, 2023, 57 , 14849-14860, available in Munin at https://hdl.handle.net/10037/31574 . Paper 3: Cioni, L., Nikiforov, V., Benskin, J.P., Coêlho, A.C.M.F., Lechtenfeld, O.J., Nøst, T.H., Plassmann, M.M., Reemtsma, T., Sandanger, T.M. & Herzke D. Combining advanced analytical methodologies to uncover the contribution of suspect PFAS and fluorinated pharmaceuticals to extractable organic fluorine in pooled human serum from the Tromsø Study between 1986 and 2015. (Manuscript). https://hdl.handle.net/10037/31818 openAccess Copyright 2023 The Author(s) PFAS Organofluorine Tromsø Study Human exposure Time trend DOKTOR-003 Doctoral thesis Doktorgradsavhandling 2023 ftunivtroemsoe 2023-11-23T00:08:06Z Summary In the last century, there has been a dramatic increase in chemical production and number and diversity of chemicals produced. Especially, organofluorine chemistry has increased its importance due to applications in pharmaceuticals, agrochemicals, refrigerant gases and in consumer products and industry with fluoropolymers and per- and polyfluoroalkyl substances (PFAS). PFAS are receiving international attention due to ubiquitous detection in the environment and in humans, their persistence and potential health and environmental impacts. Due to these concerns, production of some PFAS has been reduced internationally and their human blood concentrations are declining globally. However, PFAS production shifted towards new chemistries. Since >4700 PFAS exist and there is growing evidence about the presence of unknown organofluorine in human blood, there are concerns about PFAS human exposure underestimation. The overall thesis aim was to improve the description of PFAS and organofluorine exposure over three decades (1986-2015), covering a relevant timeframe for PFAS legislation and production changes. To achieve our goal, a new method to measure unknown PFAS in human blood had to be developed and we developed the total oxidizable precursors (TOP) assay for human serum. Pooled serum samples from the Tromsø Study collected in 1986, 2007 and 2015 were analysed using a fluorine mass-balance approach that included total fluorine (TF), extractable organic fluorine (EOF), target PFAS, suspect screening and, for the first time, TOP and fluorinated pharmaceuticals. Our study shows that TF concentrations did not change significantly between years, while EOF decreased between 1986-2007 and did not change between 2007-2015. However, the composition of EOF has been changing through years. While PFAS concentrations were highest in 2007, TOP concentrations were low and did not change between years and fluorinated pharmaceuticals and metabolites concentrations increased between 1986-2015. Further, suspect screening ... Doctoral or Postdoctoral Thesis Tromsø University of Tromsø: Munin Open Research Archive Tromsø |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
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PFAS Organofluorine Tromsø Study Human exposure Time trend DOKTOR-003 |
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PFAS Organofluorine Tromsø Study Human exposure Time trend DOKTOR-003 Cioni, Lara Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015 |
topic_facet |
PFAS Organofluorine Tromsø Study Human exposure Time trend DOKTOR-003 |
description |
Summary In the last century, there has been a dramatic increase in chemical production and number and diversity of chemicals produced. Especially, organofluorine chemistry has increased its importance due to applications in pharmaceuticals, agrochemicals, refrigerant gases and in consumer products and industry with fluoropolymers and per- and polyfluoroalkyl substances (PFAS). PFAS are receiving international attention due to ubiquitous detection in the environment and in humans, their persistence and potential health and environmental impacts. Due to these concerns, production of some PFAS has been reduced internationally and their human blood concentrations are declining globally. However, PFAS production shifted towards new chemistries. Since >4700 PFAS exist and there is growing evidence about the presence of unknown organofluorine in human blood, there are concerns about PFAS human exposure underestimation. The overall thesis aim was to improve the description of PFAS and organofluorine exposure over three decades (1986-2015), covering a relevant timeframe for PFAS legislation and production changes. To achieve our goal, a new method to measure unknown PFAS in human blood had to be developed and we developed the total oxidizable precursors (TOP) assay for human serum. Pooled serum samples from the Tromsø Study collected in 1986, 2007 and 2015 were analysed using a fluorine mass-balance approach that included total fluorine (TF), extractable organic fluorine (EOF), target PFAS, suspect screening and, for the first time, TOP and fluorinated pharmaceuticals. Our study shows that TF concentrations did not change significantly between years, while EOF decreased between 1986-2007 and did not change between 2007-2015. However, the composition of EOF has been changing through years. While PFAS concentrations were highest in 2007, TOP concentrations were low and did not change between years and fluorinated pharmaceuticals and metabolites concentrations increased between 1986-2015. Further, suspect screening ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Cioni, Lara |
author_facet |
Cioni, Lara |
author_sort |
Cioni, Lara |
title |
Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015 |
title_short |
Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015 |
title_full |
Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015 |
title_fullStr |
Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015 |
title_full_unstemmed |
Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015 |
title_sort |
human exposure to pfas and other anthropogenic organofluorine chemicals in tromsø between 1986 and 2015 |
publisher |
UiT The Arctic University of Norway |
publishDate |
2023 |
url |
https://hdl.handle.net/10037/31818 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Paper 1: Cioni, L., Nikiforov, V., Coêlho, A.C.M.F., Sandanger, T.M. & Herzke, D. (2022). Total oxidizable precursors assay for PFAS in human serum. Environment International, 170 , 107656. Also available in Munin at https://hdl.handle.net/10037/27580 . Paper 2: Cioni, L., Plassmann, M.M., Benskin, J.P., Coêlho, A.C.M.F., Nøst, T.H., Rylander, C., Nikiforov, V., Sandanger, T.M. & Herzke D. Fluorine mass balance, including total fluorine, extractable organic fluorine, oxidizable precursors and target PFAS, in pooled human serum from the Tromsø population in 1986, 2007 and 2015. (Accepted manuscript). Now published in Environmental Science and Technology, 2023, 57 , 14849-14860, available in Munin at https://hdl.handle.net/10037/31574 . Paper 3: Cioni, L., Nikiforov, V., Benskin, J.P., Coêlho, A.C.M.F., Lechtenfeld, O.J., Nøst, T.H., Plassmann, M.M., Reemtsma, T., Sandanger, T.M. & Herzke D. Combining advanced analytical methodologies to uncover the contribution of suspect PFAS and fluorinated pharmaceuticals to extractable organic fluorine in pooled human serum from the Tromsø Study between 1986 and 2015. (Manuscript). https://hdl.handle.net/10037/31818 |
op_rights |
openAccess Copyright 2023 The Author(s) |
_version_ |
1785576288259407872 |