Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016
Background - The aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high-sensitivity C-reactive protein (hs-CRP), and glycated hemogl...
Published in: | Journal of Periodontology |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Online Access: | https://hdl.handle.net/10037/30796 https://doi.org/10.1002/JPER.23-0108 |
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ftunivtroemsoe:oai:munin.uit.no:10037/30796 2023-10-09T21:56:17+02:00 Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016 Asa'ad, Farah Petrenya, Natalia Jönsson, Birgitta Holde, Gro Eirin Oscarson, Nils Hadler-Olsen, Elin Synnøve Vieira, Alexandre R Petzold, Max Larsson, Lena 2023-06-29 https://hdl.handle.net/10037/30796 https://doi.org/10.1002/JPER.23-0108 eng eng Wiley Journal of Periodontology Asa'ad, Petrenya, Jönsson, Holde, Oscarson, Hadler-Olsen, Vieira, Petzold, Larsson. Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016. Journal of Periodontology. 2023 FRIDAID 2171659 doi:10.1002/JPER.23-0108 0022-3492 1943-3670 https://hdl.handle.net/10037/30796 Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) openAccess Copyright 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2023 ftunivtroemsoe https://doi.org/10.1002/JPER.23-0108 2023-09-13T23:07:44Z Background - The aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high-sensitivity C-reactive protein (hs-CRP), and glycated hemoglobin (HbA1c) levels. Methods - We included participants with periodontal examination (n = 3633, aged: 40–93 years) from the Tromsø Study seventh survey (2015–2016), Norway. Periodontitis was defined according to the 2017 AAP/EFP classification system as no periodontitis, grades A, B, or C. Salivary DNA was extracted and genotyping was performed to investigate four SNPs (rs2288349, rs35474715, rs34023346, and rs10010325) in the sequence of the genes DNMT1, IDH2, TET1, and TET2. Association between SNPs and periodontitis was analyzed by logistic regression adjusted for age, sex, and smoking. Subgroup analyses on participants aged 40–49 years were performed. Results - In participants aged 40-49 years, homozygous carriage of minor A-allele of rs2288349 (DNMT1) was associated with decreased susceptibility to periodontitis (grade A: odds ratio [OR] 0.55; p = 0.014: grade B/C OR 0.48; p = 0.004). The minor A-allele of rs10010325 (TET2) was associated with increased susceptibility to periodontitis (grade A OR 1.69; p = 0.035: grade B/C OR 1.90; p = 0.014). In the entire sample, homozygous carriage of the G-allele of rs35474715 (IDH2) was associated with having ≤24 teeth (OR 1.31; p = 0.018). Homozygous carriage of the A-allele of TET2 was associated with hs-CRP≥3 mg/L (OR 1.37; p = 0.025) and HbA1c≥6.5% (OR 1.62; p = 0.028). Conclusions - In this Norwegian population, there were associations between polymorphism in genes related to DNA methylation and periodontitis, tooth loss, low-grade inflammation, and hyperglycemia. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø Journal of Periodontology |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
description |
Background - The aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high-sensitivity C-reactive protein (hs-CRP), and glycated hemoglobin (HbA1c) levels. Methods - We included participants with periodontal examination (n = 3633, aged: 40–93 years) from the Tromsø Study seventh survey (2015–2016), Norway. Periodontitis was defined according to the 2017 AAP/EFP classification system as no periodontitis, grades A, B, or C. Salivary DNA was extracted and genotyping was performed to investigate four SNPs (rs2288349, rs35474715, rs34023346, and rs10010325) in the sequence of the genes DNMT1, IDH2, TET1, and TET2. Association between SNPs and periodontitis was analyzed by logistic regression adjusted for age, sex, and smoking. Subgroup analyses on participants aged 40–49 years were performed. Results - In participants aged 40-49 years, homozygous carriage of minor A-allele of rs2288349 (DNMT1) was associated with decreased susceptibility to periodontitis (grade A: odds ratio [OR] 0.55; p = 0.014: grade B/C OR 0.48; p = 0.004). The minor A-allele of rs10010325 (TET2) was associated with increased susceptibility to periodontitis (grade A OR 1.69; p = 0.035: grade B/C OR 1.90; p = 0.014). In the entire sample, homozygous carriage of the G-allele of rs35474715 (IDH2) was associated with having ≤24 teeth (OR 1.31; p = 0.018). Homozygous carriage of the A-allele of TET2 was associated with hs-CRP≥3 mg/L (OR 1.37; p = 0.025) and HbA1c≥6.5% (OR 1.62; p = 0.028). Conclusions - In this Norwegian population, there were associations between polymorphism in genes related to DNA methylation and periodontitis, tooth loss, low-grade inflammation, and hyperglycemia. |
format |
Article in Journal/Newspaper |
author |
Asa'ad, Farah Petrenya, Natalia Jönsson, Birgitta Holde, Gro Eirin Oscarson, Nils Hadler-Olsen, Elin Synnøve Vieira, Alexandre R Petzold, Max Larsson, Lena |
spellingShingle |
Asa'ad, Farah Petrenya, Natalia Jönsson, Birgitta Holde, Gro Eirin Oscarson, Nils Hadler-Olsen, Elin Synnøve Vieira, Alexandre R Petzold, Max Larsson, Lena Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016 |
author_facet |
Asa'ad, Farah Petrenya, Natalia Jönsson, Birgitta Holde, Gro Eirin Oscarson, Nils Hadler-Olsen, Elin Synnøve Vieira, Alexandre R Petzold, Max Larsson, Lena |
author_sort |
Asa'ad, Farah |
title |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016 |
title_short |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016 |
title_full |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016 |
title_fullStr |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016 |
title_full_unstemmed |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016 |
title_sort |
polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity c-reactive protein and glycated hemoglobin: the tromsø study 2015-2016 |
publisher |
Wiley |
publishDate |
2023 |
url |
https://hdl.handle.net/10037/30796 https://doi.org/10.1002/JPER.23-0108 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Journal of Periodontology Asa'ad, Petrenya, Jönsson, Holde, Oscarson, Hadler-Olsen, Vieira, Petzold, Larsson. Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016. Journal of Periodontology. 2023 FRIDAID 2171659 doi:10.1002/JPER.23-0108 0022-3492 1943-3670 https://hdl.handle.net/10037/30796 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) openAccess Copyright 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0 |
op_doi |
https://doi.org/10.1002/JPER.23-0108 |
container_title |
Journal of Periodontology |
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1779320923045756928 |