Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization
first_pagesettingsOrder Article Reprints Open AccessArticle Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization by Carlota J. F. Conceição 1,2ORCID,Elin Moe 3,4,Paulo A. Ribeiro 2ORCID andMaria Raposo 2,*ORCID 1 CEFITEC, Department of Physics, NOVA Scho...
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Online Access: | https://hdl.handle.net/10037/29979 https://doi.org/10.3390/nano13101613 |
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ftunivtroemsoe:oai:munin.uit.no:10037/29979 2023-09-05T13:23:47+02:00 Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization Conceição, Carlota J. F. Moe, Elin Ribeiro, Paulo A. Raposo, Maria 2023-05-11 https://hdl.handle.net/10037/29979 https://doi.org/10.3390/nano13101613 eng eng MDPI Nanomaterials Conceição, Moe, Ribeiro, Raposo. Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization. Nanomaterials. 2023;13(10) FRIDAID 2154224 doi:10.3390/nano13101613 2079-4991 https://hdl.handle.net/10037/29979 Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2023 The Author(s) https://creativecommons.org/licenses/by/4.0 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2023 ftunivtroemsoe https://doi.org/10.3390/nano13101613 2023-08-16T23:06:45Z first_pagesettingsOrder Article Reprints Open AccessArticle Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization by Carlota J. F. Conceição 1,2ORCID,Elin Moe 3,4,Paulo A. Ribeiro 2ORCID andMaria Raposo 2,*ORCID 1 CEFITEC, Department of Physics, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal 2 Laboratory of Instrumentation, Biomedical Engineering and Radiation Physics (LIBPhys-UNL), Department of Physics, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal 3 Institute of Chemical and Biological Technology (ITQB NOVA), The New University of Lisbon, 2780-157 Oeiras, Portugal 4 Department of Chemistry, UiT—The Arctic University of Norway, N-9037 Tromsø, Norway * Author to whom correspondence should be addressed. Nanomaterials 2023, 13(10), 1613; https://doi.org/10.3390/nano13101613 Received: 4 April 2023 / Revised: 7 May 2023 / Accepted: 9 May 2023 / Published: 11 May 2023 (This article belongs to the Special Issue Application of Lipid Nanoparticles in Drug and Gene Delivery) Download Browse Figures Review Reports Versions Notes Abstract The development of a lipid nano-delivery system was attempted for three specific poly (ADP-ribose) polymerase 1 (PARP1) inhibitors: Veliparib, Rucaparib, and Niraparib. Simple lipid and dual lipid formulations with 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1′-glycerol) sodium salt (DPPG) and 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) were developed and tested following the thin-film method. DPPG-encapsulating inhibitors presented the best fit in terms of encapsulation efficiency (>40%, translates into concentrations as high as 100 µM), zeta potential values (below −30 mV), and population distribution (single population profile). The particle size of the main population of interest was ~130 nm in diameter. Kinetic release studies showed that DPPG-encapsulating PARP1 inhibitors present slower drug release rates than liposome control ... Article in Journal/Newspaper Tromsø Arctic University of Norway UiT The Arctic University of Norway University of Tromsø: Munin Open Research Archive Arctic Carlota ENVELOPE(-59.697,-59.697,-62.371,-62.371) Moe ENVELOPE(-45.683,-45.683,-60.733,-60.733) Norway Tromsø Nanomaterials 13 10 1613 |
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University of Tromsø: Munin Open Research Archive |
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English |
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first_pagesettingsOrder Article Reprints Open AccessArticle Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization by Carlota J. F. Conceição 1,2ORCID,Elin Moe 3,4,Paulo A. Ribeiro 2ORCID andMaria Raposo 2,*ORCID 1 CEFITEC, Department of Physics, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal 2 Laboratory of Instrumentation, Biomedical Engineering and Radiation Physics (LIBPhys-UNL), Department of Physics, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal 3 Institute of Chemical and Biological Technology (ITQB NOVA), The New University of Lisbon, 2780-157 Oeiras, Portugal 4 Department of Chemistry, UiT—The Arctic University of Norway, N-9037 Tromsø, Norway * Author to whom correspondence should be addressed. Nanomaterials 2023, 13(10), 1613; https://doi.org/10.3390/nano13101613 Received: 4 April 2023 / Revised: 7 May 2023 / Accepted: 9 May 2023 / Published: 11 May 2023 (This article belongs to the Special Issue Application of Lipid Nanoparticles in Drug and Gene Delivery) Download Browse Figures Review Reports Versions Notes Abstract The development of a lipid nano-delivery system was attempted for three specific poly (ADP-ribose) polymerase 1 (PARP1) inhibitors: Veliparib, Rucaparib, and Niraparib. Simple lipid and dual lipid formulations with 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1′-glycerol) sodium salt (DPPG) and 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) were developed and tested following the thin-film method. DPPG-encapsulating inhibitors presented the best fit in terms of encapsulation efficiency (>40%, translates into concentrations as high as 100 µM), zeta potential values (below −30 mV), and population distribution (single population profile). The particle size of the main population of interest was ~130 nm in diameter. Kinetic release studies showed that DPPG-encapsulating PARP1 inhibitors present slower drug release rates than liposome control ... |
format |
Article in Journal/Newspaper |
author |
Conceição, Carlota J. F. Moe, Elin Ribeiro, Paulo A. Raposo, Maria |
spellingShingle |
Conceição, Carlota J. F. Moe, Elin Ribeiro, Paulo A. Raposo, Maria Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization |
author_facet |
Conceição, Carlota J. F. Moe, Elin Ribeiro, Paulo A. Raposo, Maria |
author_sort |
Conceição, Carlota J. F. |
title |
Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization |
title_short |
Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization |
title_full |
Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization |
title_fullStr |
Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization |
title_full_unstemmed |
Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization |
title_sort |
liposome formulations for the strategic delivery of parp1 inhibitors: development and optimization |
publisher |
MDPI |
publishDate |
2023 |
url |
https://hdl.handle.net/10037/29979 https://doi.org/10.3390/nano13101613 |
long_lat |
ENVELOPE(-59.697,-59.697,-62.371,-62.371) ENVELOPE(-45.683,-45.683,-60.733,-60.733) |
geographic |
Arctic Carlota Moe Norway Tromsø |
geographic_facet |
Arctic Carlota Moe Norway Tromsø |
genre |
Tromsø Arctic University of Norway UiT The Arctic University of Norway |
genre_facet |
Tromsø Arctic University of Norway UiT The Arctic University of Norway |
op_relation |
Nanomaterials Conceição, Moe, Ribeiro, Raposo. Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization. Nanomaterials. 2023;13(10) FRIDAID 2154224 doi:10.3390/nano13101613 2079-4991 https://hdl.handle.net/10037/29979 |
op_rights |
Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2023 The Author(s) https://creativecommons.org/licenses/by/4.0 |
op_doi |
https://doi.org/10.3390/nano13101613 |
container_title |
Nanomaterials |
container_volume |
13 |
container_issue |
10 |
container_start_page |
1613 |
_version_ |
1776204363879940096 |