Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
Background Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nond...
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Online Access: | https://hdl.handle.net/10037/29839 https://doi.org/10.1371/journal.pone.0281239 |
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ftunivtroemsoe:oai:munin.uit.no:10037/29839 2023-09-05T13:23:46+02:00 Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study Bekkelund, Svein Ivar 2023-02-02 https://hdl.handle.net/10037/29839 https://doi.org/10.1371/journal.pone.0281239 eng eng PLOS PLOS ONE Bekkelund. Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. PLOS ONE. 2023;18(2) FRIDAID 2150839 doi:10.1371/journal.pone.0281239 1932-6203 https://hdl.handle.net/10037/29839 Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2023 The Author(s) https://creativecommons.org/licenses/by/4.0 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2023 ftunivtroemsoe https://doi.org/10.1371/journal.pone.0281239 2023-08-16T23:06:45Z Background Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population. Methods Associations between CK and the outcome variable HbA1C (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA1C (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. Results Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA1C (%) in the “high CK” group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the “normal CK” group, P <0.001. CK increased significantly and linearly with higher levels of HbA 1C (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA 1C (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA 1C (%). Conclusion These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø PLOS ONE 18 2 e0281239 |
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University of Tromsø: Munin Open Research Archive |
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language |
English |
description |
Background Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population. Methods Associations between CK and the outcome variable HbA1C (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA1C (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. Results Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA1C (%) in the “high CK” group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the “normal CK” group, P <0.001. CK increased significantly and linearly with higher levels of HbA 1C (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA 1C (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA 1C (%). Conclusion These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population. |
format |
Article in Journal/Newspaper |
author |
Bekkelund, Svein Ivar |
spellingShingle |
Bekkelund, Svein Ivar Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
author_facet |
Bekkelund, Svein Ivar |
author_sort |
Bekkelund, Svein Ivar |
title |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_short |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_full |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_fullStr |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_full_unstemmed |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_sort |
creatine kinase is associated with glycated haemoglobin in a nondiabetic population. the tromsø study |
publisher |
PLOS |
publishDate |
2023 |
url |
https://hdl.handle.net/10037/29839 https://doi.org/10.1371/journal.pone.0281239 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
PLOS ONE Bekkelund. Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. PLOS ONE. 2023;18(2) FRIDAID 2150839 doi:10.1371/journal.pone.0281239 1932-6203 https://hdl.handle.net/10037/29839 |
op_rights |
Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2023 The Author(s) https://creativecommons.org/licenses/by/4.0 |
op_doi |
https://doi.org/10.1371/journal.pone.0281239 |
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PLOS ONE |
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18 |
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2 |
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e0281239 |
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1776204348711239680 |