Plasma levels of P-selectin and future risk of incident venous thromboembolism
Background - P-selectin levels are elevated following acute deep vein thrombosis and reported to predict recurrent venous thromboembolism (VTE) and cancer-associated VTE. Yet, it is unknown whether plasma P-selectin levels are associated with incident VTE. Objectives - We aimed to investigate the as...
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Online Access: | https://hdl.handle.net/10037/29783 https://doi.org/10.1016/j.jtha.2023.04.038 |
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ftunivtroemsoe:oai:munin.uit.no:10037/29783 2023-08-27T04:12:23+02:00 Plasma levels of P-selectin and future risk of incident venous thromboembolism Swamy, Samantha Ueland, Thor Hansen, John Bjarne Snir, Omri Brækkan, Sigrid Kufaas 2023-05-12 https://hdl.handle.net/10037/29783 https://doi.org/10.1016/j.jtha.2023.04.038 eng eng Elsevier Journal of Thrombosis and Haemostasis Swamy, Ueland, Hansen, Snir, Brækkan. Plasma levels of P-selectin and future risk of incident venous thromboembolism. Journal of Thrombosis and Haemostasis. 2023 FRIDAID 2155060 doi:10.1016/j.jtha.2023.04.038 1538-7933 1538-7836 https://hdl.handle.net/10037/29783 Attribution 4.0 International (CC BY 4.0) Copyright 2023 The Author(s) https://creativecommons.org/licenses/by/4.0 Journal article Tidsskriftartikkel publishedVersion 2023 ftunivtroemsoe https://doi.org/10.1016/j.jtha.2023.04.038 2023-08-09T23:07:01Z Background - P-selectin levels are elevated following acute deep vein thrombosis and reported to predict recurrent venous thromboembolism (VTE) and cancer-associated VTE. Yet, it is unknown whether plasma P-selectin levels are associated with incident VTE. Objectives - We aimed to investigate the association between plasma P-selectin levels and risk of future incident VTE. Methods - We performed a nested case-control study in 415 patients with VTE and 843 age- and sex-matched controls derived from the general population (Tromsø IV Study). Plasma P-selectin levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratios (ORs) for VTE across quartiles of plasma P-selectin level. Sex-stratified analysis was also performed. Results - Plasma P-selectin levels were higher in men (41.4 ng/mL) than in women (38.7 ng/mL, p = .0046). We found no association between plasma P-selectin levels and risk of VTE in the overall analyses. However, sex-stratified analyses revealed that women with P-selectin levels in the highest quartile (>44.3 ng/mL) had higher risk of VTE (OR, 1.63; 95% CI, 1.01-2.64) than women with P-selectin levels in the lowest quartile (≤29.9 ng/mL). In contrast, higher levels of P-selectin were apparently associated with lower risk of VTE in men (OR for highest vs lowest quartile of P-selectin, 0.69; 95% CI, 0.42-1.15). The observed associations were stronger when the time between blood sampling and VTE was shorter. Conclusion - Elevated levels of plasma P-selectin were associated with increased risk of VTE in women but not in men, suggesting a differential impact of sex on the association between P-selectin and VTE risk. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Journal of Thrombosis and Haemostasis 21 9 2451 2460 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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language |
English |
description |
Background - P-selectin levels are elevated following acute deep vein thrombosis and reported to predict recurrent venous thromboembolism (VTE) and cancer-associated VTE. Yet, it is unknown whether plasma P-selectin levels are associated with incident VTE. Objectives - We aimed to investigate the association between plasma P-selectin levels and risk of future incident VTE. Methods - We performed a nested case-control study in 415 patients with VTE and 843 age- and sex-matched controls derived from the general population (Tromsø IV Study). Plasma P-selectin levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratios (ORs) for VTE across quartiles of plasma P-selectin level. Sex-stratified analysis was also performed. Results - Plasma P-selectin levels were higher in men (41.4 ng/mL) than in women (38.7 ng/mL, p = .0046). We found no association between plasma P-selectin levels and risk of VTE in the overall analyses. However, sex-stratified analyses revealed that women with P-selectin levels in the highest quartile (>44.3 ng/mL) had higher risk of VTE (OR, 1.63; 95% CI, 1.01-2.64) than women with P-selectin levels in the lowest quartile (≤29.9 ng/mL). In contrast, higher levels of P-selectin were apparently associated with lower risk of VTE in men (OR for highest vs lowest quartile of P-selectin, 0.69; 95% CI, 0.42-1.15). The observed associations were stronger when the time between blood sampling and VTE was shorter. Conclusion - Elevated levels of plasma P-selectin were associated with increased risk of VTE in women but not in men, suggesting a differential impact of sex on the association between P-selectin and VTE risk. |
format |
Article in Journal/Newspaper |
author |
Swamy, Samantha Ueland, Thor Hansen, John Bjarne Snir, Omri Brækkan, Sigrid Kufaas |
spellingShingle |
Swamy, Samantha Ueland, Thor Hansen, John Bjarne Snir, Omri Brækkan, Sigrid Kufaas Plasma levels of P-selectin and future risk of incident venous thromboembolism |
author_facet |
Swamy, Samantha Ueland, Thor Hansen, John Bjarne Snir, Omri Brækkan, Sigrid Kufaas |
author_sort |
Swamy, Samantha |
title |
Plasma levels of P-selectin and future risk of incident venous thromboembolism |
title_short |
Plasma levels of P-selectin and future risk of incident venous thromboembolism |
title_full |
Plasma levels of P-selectin and future risk of incident venous thromboembolism |
title_fullStr |
Plasma levels of P-selectin and future risk of incident venous thromboembolism |
title_full_unstemmed |
Plasma levels of P-selectin and future risk of incident venous thromboembolism |
title_sort |
plasma levels of p-selectin and future risk of incident venous thromboembolism |
publisher |
Elsevier |
publishDate |
2023 |
url |
https://hdl.handle.net/10037/29783 https://doi.org/10.1016/j.jtha.2023.04.038 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Journal of Thrombosis and Haemostasis Swamy, Ueland, Hansen, Snir, Brækkan. Plasma levels of P-selectin and future risk of incident venous thromboembolism. Journal of Thrombosis and Haemostasis. 2023 FRIDAID 2155060 doi:10.1016/j.jtha.2023.04.038 1538-7933 1538-7836 https://hdl.handle.net/10037/29783 |
op_rights |
Attribution 4.0 International (CC BY 4.0) Copyright 2023 The Author(s) https://creativecommons.org/licenses/by/4.0 |
op_doi |
https://doi.org/10.1016/j.jtha.2023.04.038 |
container_title |
Journal of Thrombosis and Haemostasis |
container_volume |
21 |
container_issue |
9 |
container_start_page |
2451 |
op_container_end_page |
2460 |
_version_ |
1775356459089920000 |