Physical activity and the structure and function of the left side of the heart
Current knowledge about the relationship between exercise and cardiac remodelling is mostly based on studies of athletes. Little is known about cardiac adaptations to moderate doses of exercise in the general adult and elderly population, and whether exercise-induced cardiac remodelling is a benign...
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UiT The Arctic University of Norway
2023
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ftunivtroemsoe:oai:munin.uit.no:10037/28634 2024-06-02T08:15:21+00:00 Physical activity and the structure and function of the left side of the heart Heitmann, Kim Arne 2023-03-16 https://hdl.handle.net/10037/28634 eng eng UiT The Arctic University of Norway UiT Norges arktiske universitet Paper I: Heitmann, K.A., Welde. B., Løchen, M.-L., Stylidis, M., Schirmer, H. & Morseth, B. (2022). Longitudinal associations between cumulative physical activity and change in structure and function of the left side of the heart: The Tromsø study 2007-2016. Frontiers in Cardiovascular Medicine, 9 , 882077. Also available in Munin at https://hdl.handle.net/10037/26702 . Paper II: Heitmann, K.A., Løchen, M.-L., Hopstock, L.A., Stylidis, M., Welde, B., Schirmer, H. & Morseth, B. (2021). Cross-sectional associations between accelerometry-measured physical activity, left atrial size, and indices of left ventricular diastolic dysfunction: The Tromsø Study. Preventive Medicine Reports, 21 , 101290. Also available in Munin at https://hdl.handle.net/10037/20289 . Paper III: Heitmann, K.A., Løchen, M.-L., Stylidis, M., Hopstock, L.A., Schirmer, H. & Morseth, B. (2022). Associations between physical activity, left atrial size and incident atrial fibrillation: the Tromsø Study 1994-2016. Open Heart, 9 (1), e001823. Also available in Munin at https://hdl.handle.net/10037/24584 . https://hdl.handle.net/10037/28634 openAccess Copyright 2023 The Author(s) VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804 VDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804 Tromsøundersøkelsen The Tromsø Study DOKTOR-003 Doctoral thesis Doktorgradsavhandling 2023 ftunivtroemsoe 2024-05-07T09:11:59Z Current knowledge about the relationship between exercise and cardiac remodelling is mostly based on studies of athletes. Little is known about cardiac adaptations to moderate doses of exercise in the general adult and elderly population, and whether exercise-induced cardiac remodelling is a benign physiological adaption of exercise or part of a pathophysiological mechanism. The main objective of this thesis was to study the association between physical activity (PA) and the structure and function of the left side of the heart. Also, we wanted to explore if exercise-related left atrial (LA) remodelling was associated with adverse cardiac alterations and increased risk of incident atrial fibrillation (AF). In paper I, we applied a longitudinal design with repeated measures of self-reported PA and echocardiographic structural and functional data. In paper II, we applied a cross-sectional design to investigate the association between device-based PA and LA size. In paper III, we applied a prospective design to investigate the association between self-reported PA, LA size, and risk of AF. The main findings of this thesis are that exercise-induced cardiac remodelling also occurs with moderate levels of habitual PA, and not only in endurance-trained athletes. Moreover, our results indicate that exercise-induced LA remodelling is a benign physiological adaptation to exercise, without being associated with reduced left ventricular (LV) diastolic function or increased risk of incident AF. Higher levels of PA were associated with increased LA size in general, and increased LV size in females. However, no change in pump function or atrioventricular ratio at rest was observed with higher levels of PA. Moreover, moderate levels of habitual PA were associated with reduced risk of AF, and active individuals with LA enlargement did not have higher risk of AF than either active or inactive with normal LA size. Nåværende kunnskap om sammenhengen mellom trening og hjerteremodellering er for det meste basert på studier av ... Doctoral or Postdoctoral Thesis Tromsø University of Tromsø: Munin Open Research Archive Tromsø |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804 VDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804 Tromsøundersøkelsen The Tromsø Study DOKTOR-003 |
spellingShingle |
VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804 VDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804 Tromsøundersøkelsen The Tromsø Study DOKTOR-003 Heitmann, Kim Arne Physical activity and the structure and function of the left side of the heart |
topic_facet |
VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804 VDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804 Tromsøundersøkelsen The Tromsø Study DOKTOR-003 |
description |
Current knowledge about the relationship between exercise and cardiac remodelling is mostly based on studies of athletes. Little is known about cardiac adaptations to moderate doses of exercise in the general adult and elderly population, and whether exercise-induced cardiac remodelling is a benign physiological adaption of exercise or part of a pathophysiological mechanism. The main objective of this thesis was to study the association between physical activity (PA) and the structure and function of the left side of the heart. Also, we wanted to explore if exercise-related left atrial (LA) remodelling was associated with adverse cardiac alterations and increased risk of incident atrial fibrillation (AF). In paper I, we applied a longitudinal design with repeated measures of self-reported PA and echocardiographic structural and functional data. In paper II, we applied a cross-sectional design to investigate the association between device-based PA and LA size. In paper III, we applied a prospective design to investigate the association between self-reported PA, LA size, and risk of AF. The main findings of this thesis are that exercise-induced cardiac remodelling also occurs with moderate levels of habitual PA, and not only in endurance-trained athletes. Moreover, our results indicate that exercise-induced LA remodelling is a benign physiological adaptation to exercise, without being associated with reduced left ventricular (LV) diastolic function or increased risk of incident AF. Higher levels of PA were associated with increased LA size in general, and increased LV size in females. However, no change in pump function or atrioventricular ratio at rest was observed with higher levels of PA. Moreover, moderate levels of habitual PA were associated with reduced risk of AF, and active individuals with LA enlargement did not have higher risk of AF than either active or inactive with normal LA size. Nåværende kunnskap om sammenhengen mellom trening og hjerteremodellering er for det meste basert på studier av ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Heitmann, Kim Arne |
author_facet |
Heitmann, Kim Arne |
author_sort |
Heitmann, Kim Arne |
title |
Physical activity and the structure and function of the left side of the heart |
title_short |
Physical activity and the structure and function of the left side of the heart |
title_full |
Physical activity and the structure and function of the left side of the heart |
title_fullStr |
Physical activity and the structure and function of the left side of the heart |
title_full_unstemmed |
Physical activity and the structure and function of the left side of the heart |
title_sort |
physical activity and the structure and function of the left side of the heart |
publisher |
UiT The Arctic University of Norway |
publishDate |
2023 |
url |
https://hdl.handle.net/10037/28634 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Paper I: Heitmann, K.A., Welde. B., Løchen, M.-L., Stylidis, M., Schirmer, H. & Morseth, B. (2022). Longitudinal associations between cumulative physical activity and change in structure and function of the left side of the heart: The Tromsø study 2007-2016. Frontiers in Cardiovascular Medicine, 9 , 882077. Also available in Munin at https://hdl.handle.net/10037/26702 . Paper II: Heitmann, K.A., Løchen, M.-L., Hopstock, L.A., Stylidis, M., Welde, B., Schirmer, H. & Morseth, B. (2021). Cross-sectional associations between accelerometry-measured physical activity, left atrial size, and indices of left ventricular diastolic dysfunction: The Tromsø Study. Preventive Medicine Reports, 21 , 101290. Also available in Munin at https://hdl.handle.net/10037/20289 . Paper III: Heitmann, K.A., Løchen, M.-L., Stylidis, M., Hopstock, L.A., Schirmer, H. & Morseth, B. (2022). Associations between physical activity, left atrial size and incident atrial fibrillation: the Tromsø Study 1994-2016. Open Heart, 9 (1), e001823. Also available in Munin at https://hdl.handle.net/10037/24584 . https://hdl.handle.net/10037/28634 |
op_rights |
openAccess Copyright 2023 The Author(s) |
_version_ |
1800739498847371264 |