Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020
Vertebral fractures have been associated with increased mortality, but findings are inconclusive, and many vertebral fractures avoid clinical attention. We investigated this association in a general population of 2,476 older adults aged ≥55 years from Tromsø, Norway, who were followed over 2007–2020...
Published in: | American Journal of Epidemiology |
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Online Access: | https://hdl.handle.net/10037/28154 https://doi.org/10.1093/aje/kwac161 |
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ftunivtroemsoe:oai:munin.uit.no:10037/28154 2023-05-15T18:34:24+02:00 Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020 Johansson, Jonas Emaus, Nina Geelhoed, Bastiaan Sagelv, Edvard Hamnvik Morseth, Bente 2022-09-16 https://hdl.handle.net/10037/28154 https://doi.org/10.1093/aje/kwac161 eng eng Oxford University Press American Journal of Epidemiology Johansson, Emaus, Geelhoed, Sagelv, Morseth. Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020. American Journal of Epidemiology. 2022 FRIDAID 2052815 doi:10.1093/aje/kwac161 0002-9262 1476-6256 https://hdl.handle.net/10037/28154 Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2022 The Author(s) https://creativecommons.org/licenses/by/4.0 CC-BY Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2022 ftunivtroemsoe https://doi.org/10.1093/aje/kwac161 2023-01-12T00:02:50Z Vertebral fractures have been associated with increased mortality, but findings are inconclusive, and many vertebral fractures avoid clinical attention. We investigated this association in a general population of 2,476 older adults aged ≥55 years from Tromsø, Norway, who were followed over 2007–2020, using dual-energy x-ray absorptiometry (DXA) at baseline to evaluate vertebral fractures (mild, moderate, or severe). We used multiple Cox regression models to estimate hazard ratios (HRs) for all-cause mortality, adjusted for age, sex, body mass index, education, smoking, alcohol intake, cardiovascular disease, and respiratory disease. Mean follow-up in the cohort was 11.2 (standard deviation, 2.7) years; 341 participants (13.8%) had ≥1 vertebral fracture at baseline, and 636 participants (25.7%) died between baseline and follow-up. Full-adjustment models showed a nonsignificant association between vertebral fracture status (yes/no) and mortality. Participants with ≥3 vertebral fractures (HR = 2.43, 95% confidence interval: 1.57, 3.78) or ≥1 severe vertebral fracture (HR = 1.65, 95% confidence interval: 1.26, 2.15) had increased mortality compared with those with no vertebral fractures. Dual-energy x-ray absorptiometry–based screening could be a potent and feasible tool in detecting vertebral fractures that are often clinically silent yet independently associated with premature death. Our data indicated that detailed vertebral assessment could be warranted for a more accurate survival estimation. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø American Journal of Epidemiology 192 1 62 69 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
description |
Vertebral fractures have been associated with increased mortality, but findings are inconclusive, and many vertebral fractures avoid clinical attention. We investigated this association in a general population of 2,476 older adults aged ≥55 years from Tromsø, Norway, who were followed over 2007–2020, using dual-energy x-ray absorptiometry (DXA) at baseline to evaluate vertebral fractures (mild, moderate, or severe). We used multiple Cox regression models to estimate hazard ratios (HRs) for all-cause mortality, adjusted for age, sex, body mass index, education, smoking, alcohol intake, cardiovascular disease, and respiratory disease. Mean follow-up in the cohort was 11.2 (standard deviation, 2.7) years; 341 participants (13.8%) had ≥1 vertebral fracture at baseline, and 636 participants (25.7%) died between baseline and follow-up. Full-adjustment models showed a nonsignificant association between vertebral fracture status (yes/no) and mortality. Participants with ≥3 vertebral fractures (HR = 2.43, 95% confidence interval: 1.57, 3.78) or ≥1 severe vertebral fracture (HR = 1.65, 95% confidence interval: 1.26, 2.15) had increased mortality compared with those with no vertebral fractures. Dual-energy x-ray absorptiometry–based screening could be a potent and feasible tool in detecting vertebral fractures that are often clinically silent yet independently associated with premature death. Our data indicated that detailed vertebral assessment could be warranted for a more accurate survival estimation. |
format |
Article in Journal/Newspaper |
author |
Johansson, Jonas Emaus, Nina Geelhoed, Bastiaan Sagelv, Edvard Hamnvik Morseth, Bente |
spellingShingle |
Johansson, Jonas Emaus, Nina Geelhoed, Bastiaan Sagelv, Edvard Hamnvik Morseth, Bente Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020 |
author_facet |
Johansson, Jonas Emaus, Nina Geelhoed, Bastiaan Sagelv, Edvard Hamnvik Morseth, Bente |
author_sort |
Johansson, Jonas |
title |
Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020 |
title_short |
Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020 |
title_full |
Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020 |
title_fullStr |
Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020 |
title_full_unstemmed |
Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020 |
title_sort |
vertebral fractures assessed by dual-energy x-ray absorptiometry and all-cause mortality. the tromsø study 2007-2020 |
publisher |
Oxford University Press |
publishDate |
2022 |
url |
https://hdl.handle.net/10037/28154 https://doi.org/10.1093/aje/kwac161 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
American Journal of Epidemiology Johansson, Emaus, Geelhoed, Sagelv, Morseth. Vertebral fractures assessed by dual-energy X-ray absorptiometry and all-cause mortality. The Tromsø Study 2007-2020. American Journal of Epidemiology. 2022 FRIDAID 2052815 doi:10.1093/aje/kwac161 0002-9262 1476-6256 https://hdl.handle.net/10037/28154 |
op_rights |
Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2022 The Author(s) https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/aje/kwac161 |
container_title |
American Journal of Epidemiology |
container_volume |
192 |
container_issue |
1 |
container_start_page |
62 |
op_container_end_page |
69 |
_version_ |
1766219134679384064 |