Hand grip strength and risk of incident venous thromboembolism: The Tromsø study
Background Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). Objectives We aimed to investigate t...
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Online Access: | https://hdl.handle.net/10037/28035 https://doi.org/10.1002/rth2.12833 |
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ftunivtroemsoe:oai:munin.uit.no:10037/28035 2023-05-15T18:34:28+02:00 Hand grip strength and risk of incident venous thromboembolism: The Tromsø study Leknessund, Oda Morelli, Vania Maris Strand, Bjørn Heine Hansen, John Bjarne Brækkan, Sigrid Kufaas 2022-11-04 https://hdl.handle.net/10037/28035 https://doi.org/10.1002/rth2.12833 eng eng Wiley Research and Practice in Thrombosis and Haemostasis https://onlinelibrary.wiley.com/doi/pdf/10.1002/rth2.12833 Leknessund OG, Morelli VM, Strand BH, Hansen JB, Brækkan SK. Hand grip strength and risk of incident venous thromboembolism: The Tromsø study. Research and Practice in Thrombosis and Haemostasis. 2022;6(7) FRIDAID 2070589 doi:10.1002/rth2.12833 2475-0379 https://hdl.handle.net/10037/28035 Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2022 The Author(s) https://creativecommons.org/licenses/by/4.0 CC-BY Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2022 ftunivtroemsoe https://doi.org/10.1002/rth2.12833 2023-01-12T00:02:50Z Background Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). Objectives We aimed to investigate the association between HGS and risk of incident VTE in a population-based cohort. Methods Participants (n = 13,704) from the fourth to seventh surveys of the Tromsø study (Tromsø4–Tromsø7, enrollment: 1994–2016) were followed throughout 2020, and all incident VTEs were recorded. HGS of the nondominant hand was measured using a Martin Vigorimeter (Tromsø4–Tromsø6) and a Jamar Digital Dynamometer (Tromsø7). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) according to weak HGS (less than 25th percentile) versus normal HGS (25th percentile or greater) were estimated using Cox regression models and adjusted for age, sex, body height, body mass index, physical activity, cardiovascular disease, and cancer. Results During a median of 6.5 years of follow-up, 545 incident VTEs occurred. Participants with weak HGS had a 27% higher risk of VTE (HR, 1.27; 95% CI, 1.03–1.57) compared to those with normal HGS. Subgroup analyses revealed that the point estimates were higher for unprovoked VTE (HR, 1.35; 95% CI, 0.96–1.91) and deep vein thrombosis (DVT; HR, 1.52; 95% CI, 1.14–2.01). Similar results were found in analyses restricted to men, women, and elderly (aged greater than 75 years). Conclusion A weak HGS was associated with increased risk of VTE, and particularly unprovoked VTE and isolated DVT. Our findings suggest that weak muscle strength may be a risk factor for VTE. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Research and Practice in Thrombosis and Haemostasis 6 7 e12833 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
description |
Background Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). Objectives We aimed to investigate the association between HGS and risk of incident VTE in a population-based cohort. Methods Participants (n = 13,704) from the fourth to seventh surveys of the Tromsø study (Tromsø4–Tromsø7, enrollment: 1994–2016) were followed throughout 2020, and all incident VTEs were recorded. HGS of the nondominant hand was measured using a Martin Vigorimeter (Tromsø4–Tromsø6) and a Jamar Digital Dynamometer (Tromsø7). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) according to weak HGS (less than 25th percentile) versus normal HGS (25th percentile or greater) were estimated using Cox regression models and adjusted for age, sex, body height, body mass index, physical activity, cardiovascular disease, and cancer. Results During a median of 6.5 years of follow-up, 545 incident VTEs occurred. Participants with weak HGS had a 27% higher risk of VTE (HR, 1.27; 95% CI, 1.03–1.57) compared to those with normal HGS. Subgroup analyses revealed that the point estimates were higher for unprovoked VTE (HR, 1.35; 95% CI, 0.96–1.91) and deep vein thrombosis (DVT; HR, 1.52; 95% CI, 1.14–2.01). Similar results were found in analyses restricted to men, women, and elderly (aged greater than 75 years). Conclusion A weak HGS was associated with increased risk of VTE, and particularly unprovoked VTE and isolated DVT. Our findings suggest that weak muscle strength may be a risk factor for VTE. |
format |
Article in Journal/Newspaper |
author |
Leknessund, Oda Morelli, Vania Maris Strand, Bjørn Heine Hansen, John Bjarne Brækkan, Sigrid Kufaas |
spellingShingle |
Leknessund, Oda Morelli, Vania Maris Strand, Bjørn Heine Hansen, John Bjarne Brækkan, Sigrid Kufaas Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
author_facet |
Leknessund, Oda Morelli, Vania Maris Strand, Bjørn Heine Hansen, John Bjarne Brækkan, Sigrid Kufaas |
author_sort |
Leknessund, Oda |
title |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_short |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_full |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_fullStr |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_full_unstemmed |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_sort |
hand grip strength and risk of incident venous thromboembolism: the tromsø study |
publisher |
Wiley |
publishDate |
2022 |
url |
https://hdl.handle.net/10037/28035 https://doi.org/10.1002/rth2.12833 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Research and Practice in Thrombosis and Haemostasis https://onlinelibrary.wiley.com/doi/pdf/10.1002/rth2.12833 Leknessund OG, Morelli VM, Strand BH, Hansen JB, Brækkan SK. Hand grip strength and risk of incident venous thromboembolism: The Tromsø study. Research and Practice in Thrombosis and Haemostasis. 2022;6(7) FRIDAID 2070589 doi:10.1002/rth2.12833 2475-0379 https://hdl.handle.net/10037/28035 |
op_rights |
Attribution 4.0 International (CC BY 4.0) openAccess Copyright 2022 The Author(s) https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1002/rth2.12833 |
container_title |
Research and Practice in Thrombosis and Haemostasis |
container_volume |
6 |
container_issue |
7 |
container_start_page |
e12833 |
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