Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study
Objective - To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N). Methods - Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–...
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Online Access: | https://hdl.handle.net/10037/27864 https://doi.org/10.1016/j.sleepx.2022.100056 |
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ftunivtroemsoe:oai:munin.uit.no:10037/27864 2023-05-15T14:25:03+02:00 Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study Uhlving Larsen, Anette Hopstock, Laila Arnesdatter Jorde, Rolf Grimnes, Guri 2022-09-06 https://hdl.handle.net/10037/27864 https://doi.org/10.1016/j.sleepx.2022.100056 eng eng Elsevier Sleep Medicine: X Uhlving Larsen, Hopstock, Jorde, Grimnes. Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study. Sleep Medicine: X. 2022;4 FRIDAID 2079006 doi:10.1016/j.sleepx.2022.100056 2590-1427 https://hdl.handle.net/10037/27864 Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) openAccess Copyright 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0 CC-BY-NC-ND Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2022 ftunivtroemsoe https://doi.org/10.1016/j.sleepx.2022.100056 2022-12-22T00:02:49Z Objective - To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N). Methods - Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents missing data on s-25(OH)D (n = 161) and/or subjective sleep measures (including sleep duration, insomnia, and daytime sleepiness)(n = 490). Based on s-25(OH)D (assessed using LC-MS/MS), participants were grouped as deficient (<30 nmol/L), insufficient (30–49.9 nmol/L), sufficient (50–75 nmol/L), or high (>75 nmol/L). Sleep duration was grouped as inadequate (ISD) if < 7 or ≥9 h. Linear and logistic regression were used to calculate unstandardized β-values and odds ratios [95% confidence intervals]. The analyses were adjusted for season, age, BMI, lifestyle factors and relevant comorbidities. Results - In both men and women, s-25(OH)D was positively associated with sleep duration, and compared to the sufficient s-25(OH)D group, the insufficient s-25(OH)D group reported significantly shorter sleep duration in both sexes. There was an increased odds of ISD in both men and women but adjusted for confounding factors this was only significant in women (1.16 [1.03, 1.32], p = .017). In men, there were no significant associations between s-25(OH)D and the remaining sleep measures. Women in the high s-25(OH)D group had lower ESS-scores (−0.28 [-0.47, −0.08], p = .006), but higher odds of insomnia (1.16 [1.01, 1.33], p = .036) compared to women in the sufficient group. Conclusions - In this Arctic population, a tenuous association was found between s-25(OH)D and subjective sleep measures, predominantly in women. Article in Journal/Newspaper Arctic Arctic Arctic Population Tromsø University of Tromsø: Munin Open Research Archive Arctic Tromsø Sleep Medicine: X 4 100056 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
description |
Objective - To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N). Methods - Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents missing data on s-25(OH)D (n = 161) and/or subjective sleep measures (including sleep duration, insomnia, and daytime sleepiness)(n = 490). Based on s-25(OH)D (assessed using LC-MS/MS), participants were grouped as deficient (<30 nmol/L), insufficient (30–49.9 nmol/L), sufficient (50–75 nmol/L), or high (>75 nmol/L). Sleep duration was grouped as inadequate (ISD) if < 7 or ≥9 h. Linear and logistic regression were used to calculate unstandardized β-values and odds ratios [95% confidence intervals]. The analyses were adjusted for season, age, BMI, lifestyle factors and relevant comorbidities. Results - In both men and women, s-25(OH)D was positively associated with sleep duration, and compared to the sufficient s-25(OH)D group, the insufficient s-25(OH)D group reported significantly shorter sleep duration in both sexes. There was an increased odds of ISD in both men and women but adjusted for confounding factors this was only significant in women (1.16 [1.03, 1.32], p = .017). In men, there were no significant associations between s-25(OH)D and the remaining sleep measures. Women in the high s-25(OH)D group had lower ESS-scores (−0.28 [-0.47, −0.08], p = .006), but higher odds of insomnia (1.16 [1.01, 1.33], p = .036) compared to women in the sufficient group. Conclusions - In this Arctic population, a tenuous association was found between s-25(OH)D and subjective sleep measures, predominantly in women. |
format |
Article in Journal/Newspaper |
author |
Uhlving Larsen, Anette Hopstock, Laila Arnesdatter Jorde, Rolf Grimnes, Guri |
spellingShingle |
Uhlving Larsen, Anette Hopstock, Laila Arnesdatter Jorde, Rolf Grimnes, Guri Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
author_facet |
Uhlving Larsen, Anette Hopstock, Laila Arnesdatter Jorde, Rolf Grimnes, Guri |
author_sort |
Uhlving Larsen, Anette |
title |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_short |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_full |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_fullStr |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_full_unstemmed |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_sort |
associations of serum 25-hydroxyvitamin d and subjective sleep measures in an arctic population: insights from the population-based tromsø study |
publisher |
Elsevier |
publishDate |
2022 |
url |
https://hdl.handle.net/10037/27864 https://doi.org/10.1016/j.sleepx.2022.100056 |
geographic |
Arctic Tromsø |
geographic_facet |
Arctic Tromsø |
genre |
Arctic Arctic Arctic Population Tromsø |
genre_facet |
Arctic Arctic Arctic Population Tromsø |
op_relation |
Sleep Medicine: X Uhlving Larsen, Hopstock, Jorde, Grimnes. Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study. Sleep Medicine: X. 2022;4 FRIDAID 2079006 doi:10.1016/j.sleepx.2022.100056 2590-1427 https://hdl.handle.net/10037/27864 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) openAccess Copyright 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0 |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.sleepx.2022.100056 |
container_title |
Sleep Medicine: X |
container_volume |
4 |
container_start_page |
100056 |
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1766297484935561216 |