Antimicrobial natural products from Arctic and sub-Arcticmarine invertebrates

• Main Author: Tadesse, Margey
• Format: Doctoral or Postdoctoral Thesis
• Language: English
• Published: Universitetet i Tromsø 2010
• Subjects: VDP::Mathematics and natural science: 400::Chemistry: 440::Pharmaceutical chemistry: 448; VDP::Matematikk og naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448; Arctic and sub-Arctic marine invertebrates; antimicrobial; cold-water sponges; ascidians; corals; bryozoans; Dendrodoa aggregata; Synoicum pulmonaria; Tegella cf spitzbergensis; tubastrine; 3-dehydroxytubastrine; synoxazolidinones A; B and C; eusynstyelamides B; D; E and F; 1D and 2D NMR; ESI-MS; Arctic; Norway; Bjørn; Haug; Tørfoss; Northern Norway
• Online Access: https://hdl.handle.net/10037/2702

The papers of the thesis are not available in Munin due to publisher's restrictions: 1. Margey Tadesse, Bjørn Gulliksen, Morten B. Strøm, Olaf B. Styrvold, Tor Haug: «Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway», Journal of Invertebrate Pathology, 99(2008), 286-293 (Elsevier). Available at http://dx.doi.org/10.1016/j.jip.2008.06.009 The accepted version of the article is avalable in Munin at http://hdl.handle.net/10037/2728 2. Margey Tadesse, Veronika Tørfoss, Morten B. Strøm, Espen Hansen, Jeanette Hammer Andersen, Klara Stensvåg, Tor Haug: «Isolation and biological activity of (E)-1-(4-hydroxystyryl)guanidine from the sub-Arctic ascidian, Dendrodoa aggregata», Biochemical Systematics and Ecology (2010) - in press-version (Elsevier). Available at http://dx.doi.org/10.1016/j.bse.2010.04.002 3. Margey Tadesse, Morten B. Strøm, Johan Svenson, Marcel Jaspars, Bruce F. Milne, Veronika Tørfoss, Jeanette H. Andersen, Espen Hansen, Klara Stensvåg and Tor Haug: «Synoxazolidinones A, B, and C; novel bioactive alkaloids from the ascidian Synoicum pulmonaria». Manuscript, published version available in Organic Letters at http://dx.doi.org/10.1021/ol101707u 4. Margey Tadesse, Jioji N. Tabudravu, Marcel Jaspars, Morten B. Strøm, Espen Hansen, Jeanette H. Andersen and Tor Haug: «The antibacterial eusynstelamides B, D, E and F, from the Arctic bryozoan Tegella cf. spitzbergensis» (manuscript) Infectious diseases are a leading cause of death world-wide and there is a growing need for new anti-infective agents to combat multi-resistant strains of bacteria and fungi. Marine natural products are promising sources of novel antimicrobial compounds. In the present thesis, an investigation into the antimicrobial metabolites of Arctic and sub-Arctic marine invertebrate species is presented. Extracts of seven ascidian species, six sponge species, a soft-alcyonid coral and a bryozoan species, were screened for their antimicrobial activities. The extracts were ...