Comparability of plasma iohexol clearance across population-based cohorts
Rationale & Objective: Glomerular filtration rate (GFR) estimation based on creatinine or cystatin C level is currently the standard method for assessing GFR in epidemiologic research and clinical trials despite several important and well-known limitations. Plasma iohexol clearance has been prop...
Published in: | American Journal of Kidney Diseases |
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Online Access: | https://hdl.handle.net/10037/26856 https://doi.org/10.1053/j.ajkd.2019.10.008 |
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ftunivtroemsoe:oai:munin.uit.no:10037/26856 2023-05-15T17:39:23+02:00 Comparability of plasma iohexol clearance across population-based cohorts Eriksen, Bjørn Odvar Schaeffner, Elke Melsom, Toralf Ebert, Natalie van der Giet, Markus Gudnason, Vilmundur Indridasson, Olafur S. Karger, Amy B. Levey, Andrew S. Schuchardt, Mirjam Sørensen, Liv Karin Pálsson, Runólfur 2019-12-23 https://hdl.handle.net/10037/26856 https://doi.org/10.1053/j.ajkd.2019.10.008 eng eng Elsevier American Journal of Kidney Diseases Eriksen BO, Schaeffner E, Melsom T, Ebert N, van der Giet M, Gudnason V, Indridasson, Karger, Levey AS, Schuchardt, Sørensen LK, Pálsson R. Comparability of plasma iohexol clearance across population-based cohorts. American Journal of Kidney Diseases. 2019, 76(1):54-62. FRIDAID 1779098 doi:10.1053/j.ajkd.2019.10.008 0272-6386 1523-6838 https://hdl.handle.net/10037/26856 openAccess Copyright 2019 The Author(s) Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2019 ftunivtroemsoe https://doi.org/10.1053/j.ajkd.2019.10.008 2022-09-21T23:00:39Z Rationale & Objective: Glomerular filtration rate (GFR) estimation based on creatinine or cystatin C level is currently the standard method for assessing GFR in epidemiologic research and clinical trials despite several important and well-known limitations. Plasma iohexol clearance has been proposed as an inexpensive method for measuring GFR that could replace estimated GFR in many research projects. However, lack of standardization for iohexol assays and the use of different protocols such as single- and multiplesample methods could potentially hamper comparisons across studies. We compared iohexol assays and GFR measurement protocols in 3 population-based European cohorts. Study Design: Cross-sectional investigation. Setting & Participants: Participants in the Age, Gene/Environment Susceptibility-Kidney Study (AGES-Kidney; n = 805), the Berlin Initiative Study (BIS, n = 570), and the Renal Iohexol Clearance Survey Follow-up Study (RENIS-FU; n = 1,324). Tests Compared: High-performance liquid chromatography analyses of iohexol. Plasma iohexol clearance calculated using single- versus multiple-sample protocols. Outcomes: Measures of agreement between methods. Results: Frozen samples from the 3 studies were obtained and iohexol concentrations were remeasured in the laboratory at the University Hospital of North Norway. Lin’s concordance correlation coefficient ρ was >0.96 and Cb (accuracy) was >0.99 for remeasured versus original serum iohexol concentrations in all 3 cohorts, and Passing-Bablok regression did not find differences between measurements, except for a slope of 1.025 (95% CI, 1.006-1.046) for the log-transformed AGES-Kidney measurements. The multiple-sample iohexol clearance measurements in AGES-Kidney and BIS were compared with single-sample GFRs derived from the same iohexol measurements. Mean bias for multiple-sample relative to single-sample GFRs in AGES-Kidney and BIS were −0.25 and −0.15 mL/min, and 99% and 97% of absolute differences were within 10% of the multiple-sample result, ... Article in Journal/Newspaper North Norway University of Tromsø: Munin Open Research Archive Norway American Journal of Kidney Diseases 76 1 54 62 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
description |
Rationale & Objective: Glomerular filtration rate (GFR) estimation based on creatinine or cystatin C level is currently the standard method for assessing GFR in epidemiologic research and clinical trials despite several important and well-known limitations. Plasma iohexol clearance has been proposed as an inexpensive method for measuring GFR that could replace estimated GFR in many research projects. However, lack of standardization for iohexol assays and the use of different protocols such as single- and multiplesample methods could potentially hamper comparisons across studies. We compared iohexol assays and GFR measurement protocols in 3 population-based European cohorts. Study Design: Cross-sectional investigation. Setting & Participants: Participants in the Age, Gene/Environment Susceptibility-Kidney Study (AGES-Kidney; n = 805), the Berlin Initiative Study (BIS, n = 570), and the Renal Iohexol Clearance Survey Follow-up Study (RENIS-FU; n = 1,324). Tests Compared: High-performance liquid chromatography analyses of iohexol. Plasma iohexol clearance calculated using single- versus multiple-sample protocols. Outcomes: Measures of agreement between methods. Results: Frozen samples from the 3 studies were obtained and iohexol concentrations were remeasured in the laboratory at the University Hospital of North Norway. Lin’s concordance correlation coefficient ρ was >0.96 and Cb (accuracy) was >0.99 for remeasured versus original serum iohexol concentrations in all 3 cohorts, and Passing-Bablok regression did not find differences between measurements, except for a slope of 1.025 (95% CI, 1.006-1.046) for the log-transformed AGES-Kidney measurements. The multiple-sample iohexol clearance measurements in AGES-Kidney and BIS were compared with single-sample GFRs derived from the same iohexol measurements. Mean bias for multiple-sample relative to single-sample GFRs in AGES-Kidney and BIS were −0.25 and −0.15 mL/min, and 99% and 97% of absolute differences were within 10% of the multiple-sample result, ... |
format |
Article in Journal/Newspaper |
author |
Eriksen, Bjørn Odvar Schaeffner, Elke Melsom, Toralf Ebert, Natalie van der Giet, Markus Gudnason, Vilmundur Indridasson, Olafur S. Karger, Amy B. Levey, Andrew S. Schuchardt, Mirjam Sørensen, Liv Karin Pálsson, Runólfur |
spellingShingle |
Eriksen, Bjørn Odvar Schaeffner, Elke Melsom, Toralf Ebert, Natalie van der Giet, Markus Gudnason, Vilmundur Indridasson, Olafur S. Karger, Amy B. Levey, Andrew S. Schuchardt, Mirjam Sørensen, Liv Karin Pálsson, Runólfur Comparability of plasma iohexol clearance across population-based cohorts |
author_facet |
Eriksen, Bjørn Odvar Schaeffner, Elke Melsom, Toralf Ebert, Natalie van der Giet, Markus Gudnason, Vilmundur Indridasson, Olafur S. Karger, Amy B. Levey, Andrew S. Schuchardt, Mirjam Sørensen, Liv Karin Pálsson, Runólfur |
author_sort |
Eriksen, Bjørn Odvar |
title |
Comparability of plasma iohexol clearance across population-based cohorts |
title_short |
Comparability of plasma iohexol clearance across population-based cohorts |
title_full |
Comparability of plasma iohexol clearance across population-based cohorts |
title_fullStr |
Comparability of plasma iohexol clearance across population-based cohorts |
title_full_unstemmed |
Comparability of plasma iohexol clearance across population-based cohorts |
title_sort |
comparability of plasma iohexol clearance across population-based cohorts |
publisher |
Elsevier |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/26856 https://doi.org/10.1053/j.ajkd.2019.10.008 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
North Norway |
genre_facet |
North Norway |
op_relation |
American Journal of Kidney Diseases Eriksen BO, Schaeffner E, Melsom T, Ebert N, van der Giet M, Gudnason V, Indridasson, Karger, Levey AS, Schuchardt, Sørensen LK, Pálsson R. Comparability of plasma iohexol clearance across population-based cohorts. American Journal of Kidney Diseases. 2019, 76(1):54-62. FRIDAID 1779098 doi:10.1053/j.ajkd.2019.10.008 0272-6386 1523-6838 https://hdl.handle.net/10037/26856 |
op_rights |
openAccess Copyright 2019 The Author(s) |
op_doi |
https://doi.org/10.1053/j.ajkd.2019.10.008 |
container_title |
American Journal of Kidney Diseases |
container_volume |
76 |
container_issue |
1 |
container_start_page |
54 |
op_container_end_page |
62 |
_version_ |
1766140155018608640 |