Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus
Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In add...
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ftunivtroemsoe:oai:munin.uit.no:10037/26658 2023-05-15T18:34:53+02:00 Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus Charles, Dolley Berg, Vivian Nøst, Therese Haugdahl Bergdahl, Ingvar A. Huber, Sandra Ayotte, Pierre Wilsgaard, Tom Averina, Maria Sandanger, Torkjel M Rylander, Charlotta 2021-09-28 https://hdl.handle.net/10037/26658 https://doi.org/10.1016/j.envres.2021.112129 eng eng Elsevier Environmental Research Charles D, Berg V, Nøst TH, Bergdahl IA, Huber SH, Ayotte P, Wilsgaard T, Averina M, Sandanger TM, Rylander C. Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus. Environmental Research. 2022;204 FRIDAID 1952168 doi:10.1016/j.envres.2021.112129 0013-9351 1096-0953 https://hdl.handle.net/10037/26658 openAccess Copyright 2022 The Author(s) Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2021 ftunivtroemsoe https://doi.org/10.1016/j.envres.2021.112129 2022-09-07T23:00:13Z Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to a complex network of factors that could impact associations with T2DM. Longitudinal studies on this topic are lacking, and few have assessed prospective and cross-sectional associations between repeated POP measurements and T2DM in the same individuals, which may shed light on causality. Objectives: To compare longitudinal trends in concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in T2DM cases and controls, and to examine prospective and cross-sectional associations between PCBs, OCPs and T2DM at different time-points before and after T2DM diagnosis in cases. Methods: We conducted a longitudinal, nested case-control study (1986–2016) of 116 T2DM cases and 139 controls from the Tromsø Study. All participants had three blood samples collected before T2DM diagnosis in cases, and up to two samples thereafter. We used linear mixed-effect models to assess temporal changes of POPs within and between T2DM cases and controls, and logistic regression models to investigate the associations between different POPs and T2DM at different time-points. Results: PCBs, trans-nonachlor, cis-nonachlor, oxychlordane, cis-heptachlor epoxide, p,p’-DDE, and p,p’-DDT declined more slowly in cases than controls, whereas β-HCH and HCB declined similarly in both groups. Most POPs showed positive associations between both pre- and post-diagnostic concentrations and T2DM, though effect estimates were imprecise. These associations were most consistent for cis-heptachlor epoxide. Discussion: The observed positive associations between certain POPs and T2DM may be because of higher POP concentrations within ... Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Environmental Research 204 112129 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
description |
Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to a complex network of factors that could impact associations with T2DM. Longitudinal studies on this topic are lacking, and few have assessed prospective and cross-sectional associations between repeated POP measurements and T2DM in the same individuals, which may shed light on causality. Objectives: To compare longitudinal trends in concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in T2DM cases and controls, and to examine prospective and cross-sectional associations between PCBs, OCPs and T2DM at different time-points before and after T2DM diagnosis in cases. Methods: We conducted a longitudinal, nested case-control study (1986–2016) of 116 T2DM cases and 139 controls from the Tromsø Study. All participants had three blood samples collected before T2DM diagnosis in cases, and up to two samples thereafter. We used linear mixed-effect models to assess temporal changes of POPs within and between T2DM cases and controls, and logistic regression models to investigate the associations between different POPs and T2DM at different time-points. Results: PCBs, trans-nonachlor, cis-nonachlor, oxychlordane, cis-heptachlor epoxide, p,p’-DDE, and p,p’-DDT declined more slowly in cases than controls, whereas β-HCH and HCB declined similarly in both groups. Most POPs showed positive associations between both pre- and post-diagnostic concentrations and T2DM, though effect estimates were imprecise. These associations were most consistent for cis-heptachlor epoxide. Discussion: The observed positive associations between certain POPs and T2DM may be because of higher POP concentrations within ... |
format |
Article in Journal/Newspaper |
author |
Charles, Dolley Berg, Vivian Nøst, Therese Haugdahl Bergdahl, Ingvar A. Huber, Sandra Ayotte, Pierre Wilsgaard, Tom Averina, Maria Sandanger, Torkjel M Rylander, Charlotta |
spellingShingle |
Charles, Dolley Berg, Vivian Nøst, Therese Haugdahl Bergdahl, Ingvar A. Huber, Sandra Ayotte, Pierre Wilsgaard, Tom Averina, Maria Sandanger, Torkjel M Rylander, Charlotta Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus |
author_facet |
Charles, Dolley Berg, Vivian Nøst, Therese Haugdahl Bergdahl, Ingvar A. Huber, Sandra Ayotte, Pierre Wilsgaard, Tom Averina, Maria Sandanger, Torkjel M Rylander, Charlotta |
author_sort |
Charles, Dolley |
title |
Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus |
title_short |
Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus |
title_full |
Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus |
title_fullStr |
Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus |
title_full_unstemmed |
Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus |
title_sort |
longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://hdl.handle.net/10037/26658 https://doi.org/10.1016/j.envres.2021.112129 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Environmental Research Charles D, Berg V, Nøst TH, Bergdahl IA, Huber SH, Ayotte P, Wilsgaard T, Averina M, Sandanger TM, Rylander C. Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus. Environmental Research. 2022;204 FRIDAID 1952168 doi:10.1016/j.envres.2021.112129 0013-9351 1096-0953 https://hdl.handle.net/10037/26658 |
op_rights |
openAccess Copyright 2022 The Author(s) |
op_doi |
https://doi.org/10.1016/j.envres.2021.112129 |
container_title |
Environmental Research |
container_volume |
204 |
container_start_page |
112129 |
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1766219855078359040 |