Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway
Background - Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between...
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Online Access: | https://hdl.handle.net/10037/26429 https://doi.org/10.1186/s12882-022-02738-2 |
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ftunivtroemsoe:oai:munin.uit.no:10037/26429 2023-05-15T15:24:03+02:00 Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway Cook, Sarah Solbu, Marit Dahl Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila Arnesdatter Kholmatova, Kamila Kahramonzhonovna Kudryavtsev, Alexander V Leon, David A. Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea 2022-04-14 https://hdl.handle.net/10037/26429 https://doi.org/10.1186/s12882-022-02738-2 eng eng BMC BMC Nephrology Cook, Solbu, Eggen, Iakunchykova, Averina, Hopstock, Kholmatova, Kudryavtsev, Leon, Malyutina, Ryabikov, Williamson, Nitsch. Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. BMC Nephrology. 2022;23(1) FRIDAID 2028928 doi:10.1186/s12882-022-02738-2 1471-2369 https://hdl.handle.net/10037/26429 openAccess Copyright 2022 The Author(s) Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2022 ftunivtroemsoe https://doi.org/10.1186/s12882-022-02738-2 2022-08-31T23:00:12Z Background - Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD. Methods - We compared age- and sex-standardised prevalence of reduced eGFR (< 60 ml/min/1.73m2 CKD-EPI creatinine equation), albuminuria and or a composite indicator of CKD (one measure of either reduced eGFR or albuminuria) between participants aged 40–69 in the population-based Know Your Heart (KYH) study, Russia (2015–2018 N = 4607) and the seventh Tromsø Study (Tromsø7), Norway (2015–2016 N = 17,646). We assessed the contribution of established CKD risk factors (low education, diabetes, hypertension, antihypertensive use, smoking, obesity) to between-study differences using logistic regression. Results - Prevalence of reduced eGFR or albuminuria was 6.5% (95% Confidence Interval (CI) 5.4, 7.7) in KYH and 4.6% (95% CI 4.0, 5.2) in Tromsø7 standardised for sex and age. Odds of both clinical outcomes were higher in KYH than Tromsø7 (reduced eGFR OR 2.06 95% CI 1.67, 2.54; albuminuria OR 1.54 95% CI 1.16, 2.03) adjusted for sex and age. Risk factor adjustment explained the observed between-study difference in albuminuria (OR 0.92 95% CI 0.68, 1.25) but only partially reduced eGFR (OR 1.42 95% CI 1.11, 1.82). The strongest explanatory factors for the between-study difference was higher use of antihypertensives (Russian sample) for reduced eGFR and mean diastolic blood pressure for albuminuria. Conclusions - We found evidence of a higher burden of CKD within the sample from the population in Arkhangelsk and Novosibirsk compared to Tromsø, partly explained by between-study population differences in established risk factors. In particular hypertension defined by medication use was an important factor associated with the higher CKD prevalence in the Russian sample. Article in Journal/Newspaper Arkhangelsk Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø BMC Nephrology 23 1 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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language |
English |
description |
Background - Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD. Methods - We compared age- and sex-standardised prevalence of reduced eGFR (< 60 ml/min/1.73m2 CKD-EPI creatinine equation), albuminuria and or a composite indicator of CKD (one measure of either reduced eGFR or albuminuria) between participants aged 40–69 in the population-based Know Your Heart (KYH) study, Russia (2015–2018 N = 4607) and the seventh Tromsø Study (Tromsø7), Norway (2015–2016 N = 17,646). We assessed the contribution of established CKD risk factors (low education, diabetes, hypertension, antihypertensive use, smoking, obesity) to between-study differences using logistic regression. Results - Prevalence of reduced eGFR or albuminuria was 6.5% (95% Confidence Interval (CI) 5.4, 7.7) in KYH and 4.6% (95% CI 4.0, 5.2) in Tromsø7 standardised for sex and age. Odds of both clinical outcomes were higher in KYH than Tromsø7 (reduced eGFR OR 2.06 95% CI 1.67, 2.54; albuminuria OR 1.54 95% CI 1.16, 2.03) adjusted for sex and age. Risk factor adjustment explained the observed between-study difference in albuminuria (OR 0.92 95% CI 0.68, 1.25) but only partially reduced eGFR (OR 1.42 95% CI 1.11, 1.82). The strongest explanatory factors for the between-study difference was higher use of antihypertensives (Russian sample) for reduced eGFR and mean diastolic blood pressure for albuminuria. Conclusions - We found evidence of a higher burden of CKD within the sample from the population in Arkhangelsk and Novosibirsk compared to Tromsø, partly explained by between-study population differences in established risk factors. In particular hypertension defined by medication use was an important factor associated with the higher CKD prevalence in the Russian sample. |
format |
Article in Journal/Newspaper |
author |
Cook, Sarah Solbu, Marit Dahl Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila Arnesdatter Kholmatova, Kamila Kahramonzhonovna Kudryavtsev, Alexander V Leon, David A. Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea |
spellingShingle |
Cook, Sarah Solbu, Marit Dahl Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila Arnesdatter Kholmatova, Kamila Kahramonzhonovna Kudryavtsev, Alexander V Leon, David A. Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
author_facet |
Cook, Sarah Solbu, Marit Dahl Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila Arnesdatter Kholmatova, Kamila Kahramonzhonovna Kudryavtsev, Alexander V Leon, David A. Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea |
author_sort |
Cook, Sarah |
title |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_short |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_full |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_fullStr |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_full_unstemmed |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_sort |
comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in russia and norway |
publisher |
BMC |
publishDate |
2022 |
url |
https://hdl.handle.net/10037/26429 https://doi.org/10.1186/s12882-022-02738-2 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Arkhangelsk Tromsø |
genre_facet |
Arkhangelsk Tromsø |
op_relation |
BMC Nephrology Cook, Solbu, Eggen, Iakunchykova, Averina, Hopstock, Kholmatova, Kudryavtsev, Leon, Malyutina, Ryabikov, Williamson, Nitsch. Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway. BMC Nephrology. 2022;23(1) FRIDAID 2028928 doi:10.1186/s12882-022-02738-2 1471-2369 https://hdl.handle.net/10037/26429 |
op_rights |
openAccess Copyright 2022 The Author(s) |
op_doi |
https://doi.org/10.1186/s12882-022-02738-2 |
container_title |
BMC Nephrology |
container_volume |
23 |
container_issue |
1 |
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1766354605989429248 |