Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients
Background - There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies serum B...
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Online Access: | https://hdl.handle.net/10037/26428 https://doi.org/10.1186/s12888-022-03744-2 |
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ftunivtroemsoe:oai:munin.uit.no:10037/26428 2023-05-15T17:24:41+02:00 Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients Soløy-Nilsen, Hedda Nygård-Odeh, Kristin Kristiansen, Magnhild Gangsøy Brekke, Ole Lars Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Øiesvold, Terje 2022-02-03 https://hdl.handle.net/10037/26428 https://doi.org/10.1186/s12888-022-03744-2 eng eng BMC BMC Psychiatry Soløy-Nilsen, Nygård-Odeh, Kristiansen, Brekke, Mollnes, Reitan, Øiesvold. Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients. BMC Psychiatry. 2022;22(1) FRIDAID 2018812 doi:10.1186/s12888-022-03744-2 1471-244X https://hdl.handle.net/10037/26428 openAccess Copyright 2022 The Author(s) Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2022 ftunivtroemsoe https://doi.org/10.1186/s12888-022-03744-2 2022-08-31T23:00:12Z Background - There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies serum BDNF correlates negatively with psychiatric disorders and disease severity. Most studies in this field are on psychiatric diagnosis and personality traits. The aim of our study is to explore associations between general psychiatric symptoms, independent of diagnostic groups, and serum BDNF as well as the inflammatory biomarker high-sensitive CRP (hs-CRP). Comparison between the group regularly using psychotropic medication and those not using psychotropic medication is conducted. Methods - The study is a cross sectional study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Bodoe, Norway. Participants were assessed on serum levels of BDNF and hs-CRP. Psychiatric symptoms were assessed by a self-rating scale (Symptom check list, SCL-90- R). Multiple linear regression model was used for statistical analyses of associations between levels of BDNF, hs-CRP and symptoms. Results - We found a positive association (p < 0.05), for most SCL-90 symptom clusters with BDNF in the psychotropic medication-free group. No associations were found in the group of patients using psychotropic medication, except one, the paranoid ideation cluster (p 0.022). No associations were found between hs-CRP and symptom clusters. Conclusion - We found no relation between symptom clusters and the inflammatory biomarker hs-CRP. Serum BDNF levels were positively associated with intensity of psychiatric symptoms in the group of patients not using psychotropic medication. Our findings are in conflict with several previous studies reporting increased hs-CRP as well as decreased rather than increased BDNF in mental suffering. Patients on psychotropic medication may not require the same upregulation ... Article in Journal/Newspaper Nordland Nordland Nordland University of Tromsø: Munin Open Research Archive Norway BMC Psychiatry 22 1 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
description |
Background - There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies serum BDNF correlates negatively with psychiatric disorders and disease severity. Most studies in this field are on psychiatric diagnosis and personality traits. The aim of our study is to explore associations between general psychiatric symptoms, independent of diagnostic groups, and serum BDNF as well as the inflammatory biomarker high-sensitive CRP (hs-CRP). Comparison between the group regularly using psychotropic medication and those not using psychotropic medication is conducted. Methods - The study is a cross sectional study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Bodoe, Norway. Participants were assessed on serum levels of BDNF and hs-CRP. Psychiatric symptoms were assessed by a self-rating scale (Symptom check list, SCL-90- R). Multiple linear regression model was used for statistical analyses of associations between levels of BDNF, hs-CRP and symptoms. Results - We found a positive association (p < 0.05), for most SCL-90 symptom clusters with BDNF in the psychotropic medication-free group. No associations were found in the group of patients using psychotropic medication, except one, the paranoid ideation cluster (p 0.022). No associations were found between hs-CRP and symptom clusters. Conclusion - We found no relation between symptom clusters and the inflammatory biomarker hs-CRP. Serum BDNF levels were positively associated with intensity of psychiatric symptoms in the group of patients not using psychotropic medication. Our findings are in conflict with several previous studies reporting increased hs-CRP as well as decreased rather than increased BDNF in mental suffering. Patients on psychotropic medication may not require the same upregulation ... |
format |
Article in Journal/Newspaper |
author |
Soløy-Nilsen, Hedda Nygård-Odeh, Kristin Kristiansen, Magnhild Gangsøy Brekke, Ole Lars Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Øiesvold, Terje |
spellingShingle |
Soløy-Nilsen, Hedda Nygård-Odeh, Kristin Kristiansen, Magnhild Gangsøy Brekke, Ole Lars Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Øiesvold, Terje Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
author_facet |
Soløy-Nilsen, Hedda Nygård-Odeh, Kristin Kristiansen, Magnhild Gangsøy Brekke, Ole Lars Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Øiesvold, Terje |
author_sort |
Soløy-Nilsen, Hedda |
title |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_short |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_full |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_fullStr |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_full_unstemmed |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_sort |
association between brain-derived neurotropic factor (bdnf), high-sensitivity c-reactive protein (hs-crp) and psychiatric symptoms in medicated and unmedicated patients |
publisher |
BMC |
publishDate |
2022 |
url |
https://hdl.handle.net/10037/26428 https://doi.org/10.1186/s12888-022-03744-2 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Nordland Nordland Nordland |
genre_facet |
Nordland Nordland Nordland |
op_relation |
BMC Psychiatry Soløy-Nilsen, Nygård-Odeh, Kristiansen, Brekke, Mollnes, Reitan, Øiesvold. Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients. BMC Psychiatry. 2022;22(1) FRIDAID 2018812 doi:10.1186/s12888-022-03744-2 1471-244X https://hdl.handle.net/10037/26428 |
op_rights |
openAccess Copyright 2022 The Author(s) |
op_doi |
https://doi.org/10.1186/s12888-022-03744-2 |
container_title |
BMC Psychiatry |
container_volume |
22 |
container_issue |
1 |
_version_ |
1766115805868589056 |