Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol
Purpose - To describe medication adherence to lipid-lowering drugs (LLDs), antihypertensive drugs, and acetylsalicylic acid (ASA) among persons with coronary heart disease (CHD) and explore its association with low-density-lipoprotein (LDL)-cholesterol, and systolic and diastolic blood pressure. Met...
Published in: | European Journal of Clinical Pharmacology |
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Online Access: | https://hdl.handle.net/10037/25956 https://doi.org/10.1007/s00228-022-03276-4 |
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ftunivtroemsoe:oai:munin.uit.no:10037/25956 2023-05-15T18:34:45+02:00 Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol Pedersen, Elisabeth Primicerio, Raul Halvorsen, Kjell H. Eggen, Anne Elise Garcia, Beate Hennie Schirmer, Henrik Waaseth, Marit 2022-01-21 https://hdl.handle.net/10037/25956 https://doi.org/10.1007/s00228-022-03276-4 eng eng Springer European Journal of Clinical Pharmacology Pedersen E, Primicerio R, Halvorsen KH, Eggen AE, Garcia BH, Schirmer H, Waaseth M. Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol. European Journal of Clinical Pharmacology. 2022 FRIDAID 1998986 doi:10.1007/s00228-022-03276-4 0031-6970 1432-1041 https://hdl.handle.net/10037/25956 openAccess Copyright 2022 The Author(s) Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2022 ftunivtroemsoe https://doi.org/10.1007/s00228-022-03276-4 2022-08-10T22:59:59Z Purpose - To describe medication adherence to lipid-lowering drugs (LLDs), antihypertensive drugs, and acetylsalicylic acid (ASA) among persons with coronary heart disease (CHD) and explore its association with low-density-lipoprotein (LDL)-cholesterol, and systolic and diastolic blood pressure. Methods - Based on record linkage between the seventh wave of the Tromsø Study and the Norwegian Prescription Database, medication adherence was calculated as the proportion of days covered (PDC) for persistent prevalent users in the period of 365 days before the attendance date. Multivariable linear regression models were used to assess the association between systolic and diastolic blood pressure and medication nonadherence to antihypertensive drugs, age, sex, lifestyle, body mass index (BMI), current and previous diabetes, and between LDL-cholesterol and medication nonadherence to LLDs, age, sex, lifestyle, BMI, and current and previous diabetes. Results - Mean PDC was 0.94 for LLDs and antihypertensive drugs and 0.97 for ASA. Among persons with PDC ≥ 0.80 for LLDs, 12.0% had an LDL-cholesterol < 1.8 mmol/L. Blood pressure < 140/90 mmHg (< 140/80 mmHg if diabetes patient) was reached by 55.1% of those with a PDC ≥ 0.80 for antihypertensive drugs. Adherence to LLDs was associated with lower LDL-cholesterol, while neither systolic nor diastolic blood pressure was associated with adherence to antihypertensive drugs. Conclusion - Adherence to antihypertensive drugs, LLDs, and ASA among persons with CHD were high despite low achievement of treatment goals for blood pressure and LDL-cholesterol. There was a statistically significant association between adherence to LLDs and LDL-cholesterol, but not between adherence to antihypertensive drugs and blood pressure. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø European Journal of Clinical Pharmacology 78 5 857 867 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
description |
Purpose - To describe medication adherence to lipid-lowering drugs (LLDs), antihypertensive drugs, and acetylsalicylic acid (ASA) among persons with coronary heart disease (CHD) and explore its association with low-density-lipoprotein (LDL)-cholesterol, and systolic and diastolic blood pressure. Methods - Based on record linkage between the seventh wave of the Tromsø Study and the Norwegian Prescription Database, medication adherence was calculated as the proportion of days covered (PDC) for persistent prevalent users in the period of 365 days before the attendance date. Multivariable linear regression models were used to assess the association between systolic and diastolic blood pressure and medication nonadherence to antihypertensive drugs, age, sex, lifestyle, body mass index (BMI), current and previous diabetes, and between LDL-cholesterol and medication nonadherence to LLDs, age, sex, lifestyle, BMI, and current and previous diabetes. Results - Mean PDC was 0.94 for LLDs and antihypertensive drugs and 0.97 for ASA. Among persons with PDC ≥ 0.80 for LLDs, 12.0% had an LDL-cholesterol < 1.8 mmol/L. Blood pressure < 140/90 mmHg (< 140/80 mmHg if diabetes patient) was reached by 55.1% of those with a PDC ≥ 0.80 for antihypertensive drugs. Adherence to LLDs was associated with lower LDL-cholesterol, while neither systolic nor diastolic blood pressure was associated with adherence to antihypertensive drugs. Conclusion - Adherence to antihypertensive drugs, LLDs, and ASA among persons with CHD were high despite low achievement of treatment goals for blood pressure and LDL-cholesterol. There was a statistically significant association between adherence to LLDs and LDL-cholesterol, but not between adherence to antihypertensive drugs and blood pressure. |
format |
Article in Journal/Newspaper |
author |
Pedersen, Elisabeth Primicerio, Raul Halvorsen, Kjell H. Eggen, Anne Elise Garcia, Beate Hennie Schirmer, Henrik Waaseth, Marit |
spellingShingle |
Pedersen, Elisabeth Primicerio, Raul Halvorsen, Kjell H. Eggen, Anne Elise Garcia, Beate Hennie Schirmer, Henrik Waaseth, Marit Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol |
author_facet |
Pedersen, Elisabeth Primicerio, Raul Halvorsen, Kjell H. Eggen, Anne Elise Garcia, Beate Hennie Schirmer, Henrik Waaseth, Marit |
author_sort |
Pedersen, Elisabeth |
title |
Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol |
title_short |
Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol |
title_full |
Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol |
title_fullStr |
Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol |
title_full_unstemmed |
Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol |
title_sort |
medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol |
publisher |
Springer |
publishDate |
2022 |
url |
https://hdl.handle.net/10037/25956 https://doi.org/10.1007/s00228-022-03276-4 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
European Journal of Clinical Pharmacology Pedersen E, Primicerio R, Halvorsen KH, Eggen AE, Garcia BH, Schirmer H, Waaseth M. Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol. European Journal of Clinical Pharmacology. 2022 FRIDAID 1998986 doi:10.1007/s00228-022-03276-4 0031-6970 1432-1041 https://hdl.handle.net/10037/25956 |
op_rights |
openAccess Copyright 2022 The Author(s) |
op_doi |
https://doi.org/10.1007/s00228-022-03276-4 |
container_title |
European Journal of Clinical Pharmacology |
container_volume |
78 |
container_issue |
5 |
container_start_page |
857 |
op_container_end_page |
867 |
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1766219661698924544 |