Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics

Infections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-r...

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Bibliographic Details
Main Author: Juskewitz, Eric
Format: Doctoral or Postdoctoral Thesis
Language:English
Published: UiT The Arctic University of Norway 2022
Subjects:
Microbiology
Antimicrobial resistance
Antibiotic
Marine environment
FtsZ
AMP
Peptidomimetic
Eusyntyelamides
DigiBiotics
ESKAPE
DOKTOR-003
Arctic
Arctic Ocean
Online Access:https://hdl.handle.net/10037/25912
id ftunivtroemsoe:oai:munin.uit.no:10037/25912
record_format openpolar
spelling ftunivtroemsoe:oai:munin.uit.no:10037/25912 2023-05-15T14:59:33+02:00 Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics Juskewitz, Eric 2022-08-12 https://hdl.handle.net/10037/25912 eng eng UiT The Arctic University of Norway UiT Norges arktiske universitet Paper I: Jenssen, M., Rainsford, P., Juskewitz, E., Andersen, J.H., Hansen, E.H., Isaksson, J., Rämä, T. & Hansen, K.Ø. (2021). Lulworthinone, a new dimeric naphthopyrone from a marine fungus in the family Lulworthiaceae with antibacterial activity against clinical methicillin-resistant Staphylococcus aureus isolates. Frontiers in Microbiology, 12 , 2862. Also available in Munin at https://hdl.handle.net/10037/22945 . Paper II: Juskewitz, E., Mishchenko, E., Dubey, V.K., Jenssen, M., Jakubec, M., Rainsford, P., … Ericson, J.U. (2022). Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric, naphthopyrone isolated from a marine fungus. Marine Drugs, 20 (5), 277. Also available in Munin at https://hdl.handle.net/10037/25925 . Paper III: Paulsen, M.H., Engqvist, M., Ausbacher, D., Anderssen, T., Langer, M.K., Haug, T., Morello, G.R., Liikanen, L.E., Blencke, H.M., Isaksson, J., Juskewitz, E., Bayer, A. & Strøm, M.B. (2021). Amphipathic barbiturates as mimics of antimicrobial peptides and the marine natural products eusynstyelamides with activity against multi-resistant clinical isolates. Journal of Medicinal Chemistry, 64 (15), 11395–11417. Also available in Munin at https://hdl.handle.net/10037/22150 . Paper IV: Karlsen, E.A., Stensen, W., Juskewitz, E., Svenson, J., Berglin, M. & Svendsen, J.S.M. (2021). Anti-colonisation effect of Au surfaces with self-assembled molecular monolayers functionalised with antimicrobial peptides on S. Epidermidis. Antibiotics, 10 (12), 1516. Also available in Munin at https://hdl.handle.net/10037/23420 . Juskewitz, E. (2022). Replication Data for: "Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric naphthopyrone isolated from a marine fungus." DataverseNO, V1, https://doi.org/10.18710/6Z0VJX . https://hdl.handle.net/10037/25912 openAccess Copyright 2022 The Author(s) Microbiology Antimicrobial resistance Antibiotic Marine environment FtsZ AMP Peptidomimetic Eusyntyelamides DigiBiotics ESKAPE DOKTOR-003 Doctoral thesis Doktorgradsavhandling 2022 ftunivtroemsoe https://doi.org/10.18710/6Z0VJX 2022-08-03T22:59:20Z Infections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-resistant bacteria. There is an obvious need for developing new antimicrobials. Natural environments, like the Arctic Ocean, offer largely underexplored biodiversity with promising natural antimicrobial products. This thesis investigates marine and marine-inspired molecules for their antibacterial properties and potential applications. Doctoral or Postdoctoral Thesis Arctic Arctic Ocean University of Tromsø: Munin Open Research Archive Arctic Arctic Ocean
institution Open Polar
collection University of Tromsø: Munin Open Research Archive
op_collection_id ftunivtroemsoe
language English
topic Microbiology
Antimicrobial resistance
Antibiotic
Marine environment
FtsZ
AMP
Peptidomimetic
Eusyntyelamides
DigiBiotics
ESKAPE
DOKTOR-003
spellingShingle Microbiology
Antimicrobial resistance
Antibiotic
Marine environment
FtsZ
AMP
Peptidomimetic
Eusyntyelamides
DigiBiotics
ESKAPE
DOKTOR-003
Juskewitz, Eric
Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics
topic_facet Microbiology
Antimicrobial resistance
Antibiotic
Marine environment
FtsZ
AMP
Peptidomimetic
Eusyntyelamides
DigiBiotics
ESKAPE
DOKTOR-003
description Infections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-resistant bacteria. There is an obvious need for developing new antimicrobials. Natural environments, like the Arctic Ocean, offer largely underexplored biodiversity with promising natural antimicrobial products. This thesis investigates marine and marine-inspired molecules for their antibacterial properties and potential applications.
format Doctoral or Postdoctoral Thesis
author Juskewitz, Eric
author_facet Juskewitz, Eric
author_sort Juskewitz, Eric
title Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics
title_short Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics
title_full Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics
title_fullStr Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics
title_full_unstemmed Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics
title_sort antimicrobial activity and mode of action - examples from natural products, peptides, and peptidomimetics
publisher UiT The Arctic University of Norway
publishDate 2022
url https://hdl.handle.net/10037/25912
geographic Arctic
Arctic Ocean
geographic_facet Arctic
Arctic Ocean
genre Arctic
Arctic Ocean
genre_facet Arctic
Arctic Ocean
op_relation Paper I: Jenssen, M., Rainsford, P., Juskewitz, E., Andersen, J.H., Hansen, E.H., Isaksson, J., Rämä, T. & Hansen, K.Ø. (2021). Lulworthinone, a new dimeric naphthopyrone from a marine fungus in the family Lulworthiaceae with antibacterial activity against clinical methicillin-resistant Staphylococcus aureus isolates. Frontiers in Microbiology, 12 , 2862. Also available in Munin at https://hdl.handle.net/10037/22945 . Paper II: Juskewitz, E., Mishchenko, E., Dubey, V.K., Jenssen, M., Jakubec, M., Rainsford, P., … Ericson, J.U. (2022). Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric, naphthopyrone isolated from a marine fungus. Marine Drugs, 20 (5), 277. Also available in Munin at https://hdl.handle.net/10037/25925 . Paper III: Paulsen, M.H., Engqvist, M., Ausbacher, D., Anderssen, T., Langer, M.K., Haug, T., Morello, G.R., Liikanen, L.E., Blencke, H.M., Isaksson, J., Juskewitz, E., Bayer, A. & Strøm, M.B. (2021). Amphipathic barbiturates as mimics of antimicrobial peptides and the marine natural products eusynstyelamides with activity against multi-resistant clinical isolates. Journal of Medicinal Chemistry, 64 (15), 11395–11417. Also available in Munin at https://hdl.handle.net/10037/22150 . Paper IV: Karlsen, E.A., Stensen, W., Juskewitz, E., Svenson, J., Berglin, M. & Svendsen, J.S.M. (2021). Anti-colonisation effect of Au surfaces with self-assembled molecular monolayers functionalised with antimicrobial peptides on S. Epidermidis. Antibiotics, 10 (12), 1516. Also available in Munin at https://hdl.handle.net/10037/23420 .
Juskewitz, E. (2022). Replication Data for: "Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric naphthopyrone isolated from a marine fungus." DataverseNO, V1, https://doi.org/10.18710/6Z0VJX .
https://hdl.handle.net/10037/25912
op_rights openAccess
Copyright 2022 The Author(s)
op_doi https://doi.org/10.18710/6Z0VJX
_version_ 1766331662981922816

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