Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics
Infections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-r...
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UiT The Arctic University of Norway
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ftunivtroemsoe:oai:munin.uit.no:10037/25912 2023-05-15T14:59:33+02:00 Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics Juskewitz, Eric 2022-08-12 https://hdl.handle.net/10037/25912 eng eng UiT The Arctic University of Norway UiT Norges arktiske universitet Paper I: Jenssen, M., Rainsford, P., Juskewitz, E., Andersen, J.H., Hansen, E.H., Isaksson, J., Rämä, T. & Hansen, K.Ø. (2021). Lulworthinone, a new dimeric naphthopyrone from a marine fungus in the family Lulworthiaceae with antibacterial activity against clinical methicillin-resistant Staphylococcus aureus isolates. Frontiers in Microbiology, 12 , 2862. Also available in Munin at https://hdl.handle.net/10037/22945 . Paper II: Juskewitz, E., Mishchenko, E., Dubey, V.K., Jenssen, M., Jakubec, M., Rainsford, P., … Ericson, J.U. (2022). Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric, naphthopyrone isolated from a marine fungus. Marine Drugs, 20 (5), 277. Also available in Munin at https://hdl.handle.net/10037/25925 . Paper III: Paulsen, M.H., Engqvist, M., Ausbacher, D., Anderssen, T., Langer, M.K., Haug, T., Morello, G.R., Liikanen, L.E., Blencke, H.M., Isaksson, J., Juskewitz, E., Bayer, A. & Strøm, M.B. (2021). Amphipathic barbiturates as mimics of antimicrobial peptides and the marine natural products eusynstyelamides with activity against multi-resistant clinical isolates. Journal of Medicinal Chemistry, 64 (15), 11395–11417. Also available in Munin at https://hdl.handle.net/10037/22150 . Paper IV: Karlsen, E.A., Stensen, W., Juskewitz, E., Svenson, J., Berglin, M. & Svendsen, J.S.M. (2021). Anti-colonisation effect of Au surfaces with self-assembled molecular monolayers functionalised with antimicrobial peptides on S. Epidermidis. Antibiotics, 10 (12), 1516. Also available in Munin at https://hdl.handle.net/10037/23420 . Juskewitz, E. (2022). Replication Data for: "Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric naphthopyrone isolated from a marine fungus." DataverseNO, V1, https://doi.org/10.18710/6Z0VJX . https://hdl.handle.net/10037/25912 openAccess Copyright 2022 The Author(s) Microbiology Antimicrobial resistance Antibiotic Marine environment FtsZ AMP Peptidomimetic Eusyntyelamides DigiBiotics ESKAPE DOKTOR-003 Doctoral thesis Doktorgradsavhandling 2022 ftunivtroemsoe https://doi.org/10.18710/6Z0VJX 2022-08-03T22:59:20Z Infections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-resistant bacteria. There is an obvious need for developing new antimicrobials. Natural environments, like the Arctic Ocean, offer largely underexplored biodiversity with promising natural antimicrobial products. This thesis investigates marine and marine-inspired molecules for their antibacterial properties and potential applications. Doctoral or Postdoctoral Thesis Arctic Arctic Ocean University of Tromsø: Munin Open Research Archive Arctic Arctic Ocean |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
Microbiology Antimicrobial resistance Antibiotic Marine environment FtsZ AMP Peptidomimetic Eusyntyelamides DigiBiotics ESKAPE DOKTOR-003 |
spellingShingle |
Microbiology Antimicrobial resistance Antibiotic Marine environment FtsZ AMP Peptidomimetic Eusyntyelamides DigiBiotics ESKAPE DOKTOR-003 Juskewitz, Eric Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics |
topic_facet |
Microbiology Antimicrobial resistance Antibiotic Marine environment FtsZ AMP Peptidomimetic Eusyntyelamides DigiBiotics ESKAPE DOKTOR-003 |
description |
Infections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-resistant bacteria. There is an obvious need for developing new antimicrobials. Natural environments, like the Arctic Ocean, offer largely underexplored biodiversity with promising natural antimicrobial products. This thesis investigates marine and marine-inspired molecules for their antibacterial properties and potential applications. |
format |
Doctoral or Postdoctoral Thesis |
author |
Juskewitz, Eric |
author_facet |
Juskewitz, Eric |
author_sort |
Juskewitz, Eric |
title |
Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics |
title_short |
Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics |
title_full |
Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics |
title_fullStr |
Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics |
title_full_unstemmed |
Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics |
title_sort |
antimicrobial activity and mode of action - examples from natural products, peptides, and peptidomimetics |
publisher |
UiT The Arctic University of Norway |
publishDate |
2022 |
url |
https://hdl.handle.net/10037/25912 |
geographic |
Arctic Arctic Ocean |
geographic_facet |
Arctic Arctic Ocean |
genre |
Arctic Arctic Ocean |
genre_facet |
Arctic Arctic Ocean |
op_relation |
Paper I: Jenssen, M., Rainsford, P., Juskewitz, E., Andersen, J.H., Hansen, E.H., Isaksson, J., Rämä, T. & Hansen, K.Ø. (2021). Lulworthinone, a new dimeric naphthopyrone from a marine fungus in the family Lulworthiaceae with antibacterial activity against clinical methicillin-resistant Staphylococcus aureus isolates. Frontiers in Microbiology, 12 , 2862. Also available in Munin at https://hdl.handle.net/10037/22945 . Paper II: Juskewitz, E., Mishchenko, E., Dubey, V.K., Jenssen, M., Jakubec, M., Rainsford, P., … Ericson, J.U. (2022). Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric, naphthopyrone isolated from a marine fungus. Marine Drugs, 20 (5), 277. Also available in Munin at https://hdl.handle.net/10037/25925 . Paper III: Paulsen, M.H., Engqvist, M., Ausbacher, D., Anderssen, T., Langer, M.K., Haug, T., Morello, G.R., Liikanen, L.E., Blencke, H.M., Isaksson, J., Juskewitz, E., Bayer, A. & Strøm, M.B. (2021). Amphipathic barbiturates as mimics of antimicrobial peptides and the marine natural products eusynstyelamides with activity against multi-resistant clinical isolates. Journal of Medicinal Chemistry, 64 (15), 11395–11417. Also available in Munin at https://hdl.handle.net/10037/22150 . Paper IV: Karlsen, E.A., Stensen, W., Juskewitz, E., Svenson, J., Berglin, M. & Svendsen, J.S.M. (2021). Anti-colonisation effect of Au surfaces with self-assembled molecular monolayers functionalised with antimicrobial peptides on S. Epidermidis. Antibiotics, 10 (12), 1516. Also available in Munin at https://hdl.handle.net/10037/23420 . Juskewitz, E. (2022). Replication Data for: "Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric naphthopyrone isolated from a marine fungus." DataverseNO, V1, https://doi.org/10.18710/6Z0VJX . https://hdl.handle.net/10037/25912 |
op_rights |
openAccess Copyright 2022 The Author(s) |
op_doi |
https://doi.org/10.18710/6Z0VJX |
_version_ |
1766331662981922816 |