Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study
Many incident cases of type 2 diabetes do not fulfil the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study p...
Published in: | European Journal of Epidemiology |
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Online Access: | https://hdl.handle.net/10037/25722 https://doi.org/10.1007/s10654-010-9540-7 |
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ftunivtroemsoe:oai:munin.uit.no:10037/25722 2023-05-15T18:33:53+02:00 Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study Joseph, Josepha Elizabeth Svartberg, Johan Njølstad, Inger Schirmer, Henrik 2010-12-28 https://hdl.handle.net/10037/25722 https://doi.org/10.1007/s10654-010-9540-7 eng eng Springer European Journal of Epidemiology (EJE) Joseph EJ, Svartberg J, Njølstad i, Schirmer H. Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study. European Journal of Epidemiology (EJE). 2011;26(2):117-124 FRIDAID 802099 doi:10.1007/s10654-010-9540-7 0393-2990 1573-7284 https://hdl.handle.net/10037/25722 openAccess Copyright 2010 The Author(s) Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2010 ftunivtroemsoe https://doi.org/10.1007/s10654-010-9540-7 2022-07-06T22:58:56Z Many incident cases of type 2 diabetes do not fulfil the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and who did not have diabetes when entering the study. A total of 492 incident cases of type 2 diabetes were registered. A metabolic score was defined according to a modified version of the National Cholesterol Education Program Adult Treatment Panel III. For those fulfilling C 3 metabolic score criteria, increasing age, body mass index (BMI), triglycerides and a family history of diabetes were independent predictors. Age, BMI, and triglycerides predicted type 2 diabetes more strongly in subjects with low metabolic score, whereas high HDL cholesterol was not protective in this low risk group. The risk associated with a positive family history was unaffected by level of metabolic score. In addition smoking, low education and in men also physical inactivity were independent risk factors only in those with low metabolic score. Adding these nonmetabolic risk factors increased correct classification from an ROC area of 77.2 to 87.1% (P value \0.0001). One half of the incident cases of type 2 diabetes were missed by using high metabolic score for risk prediction. Article in Journal/Newspaper Tromso Tromso Tromsø University of Tromsø: Munin Open Research Archive Tromso ENVELOPE(16.546,16.546,68.801,68.801) Tromsø European Journal of Epidemiology 26 2 117 124 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
description |
Many incident cases of type 2 diabetes do not fulfil the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and who did not have diabetes when entering the study. A total of 492 incident cases of type 2 diabetes were registered. A metabolic score was defined according to a modified version of the National Cholesterol Education Program Adult Treatment Panel III. For those fulfilling C 3 metabolic score criteria, increasing age, body mass index (BMI), triglycerides and a family history of diabetes were independent predictors. Age, BMI, and triglycerides predicted type 2 diabetes more strongly in subjects with low metabolic score, whereas high HDL cholesterol was not protective in this low risk group. The risk associated with a positive family history was unaffected by level of metabolic score. In addition smoking, low education and in men also physical inactivity were independent risk factors only in those with low metabolic score. Adding these nonmetabolic risk factors increased correct classification from an ROC area of 77.2 to 87.1% (P value \0.0001). One half of the incident cases of type 2 diabetes were missed by using high metabolic score for risk prediction. |
format |
Article in Journal/Newspaper |
author |
Joseph, Josepha Elizabeth Svartberg, Johan Njølstad, Inger Schirmer, Henrik |
spellingShingle |
Joseph, Josepha Elizabeth Svartberg, Johan Njølstad, Inger Schirmer, Henrik Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study |
author_facet |
Joseph, Josepha Elizabeth Svartberg, Johan Njølstad, Inger Schirmer, Henrik |
author_sort |
Joseph, Josepha Elizabeth |
title |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study |
title_short |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study |
title_full |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study |
title_fullStr |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study |
title_full_unstemmed |
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study |
title_sort |
risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of the tromso study |
publisher |
Springer |
publishDate |
2010 |
url |
https://hdl.handle.net/10037/25722 https://doi.org/10.1007/s10654-010-9540-7 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso Tromsø |
geographic_facet |
Tromso Tromsø |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
European Journal of Epidemiology (EJE) Joseph EJ, Svartberg J, Njølstad i, Schirmer H. Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study. European Journal of Epidemiology (EJE). 2011;26(2):117-124 FRIDAID 802099 doi:10.1007/s10654-010-9540-7 0393-2990 1573-7284 https://hdl.handle.net/10037/25722 |
op_rights |
openAccess Copyright 2010 The Author(s) |
op_doi |
https://doi.org/10.1007/s10654-010-9540-7 |
container_title |
European Journal of Epidemiology |
container_volume |
26 |
container_issue |
2 |
container_start_page |
117 |
op_container_end_page |
124 |
_version_ |
1766218510515568640 |