NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population
Aims The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in...
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Online Access: | https://hdl.handle.net/10037/25122 https://doi.org/10.1002/ehf2.13906 |
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ftunivtroemsoe:oai:munin.uit.no:10037/25122 2023-05-15T17:43:38+02:00 NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population Averina, Maria Stylidis, Michael Brox, Jan Schirmer, Henrik 2022-03-23 https://hdl.handle.net/10037/25122 https://doi.org/10.1002/ehf2.13906 eng eng Wiley ESC Heart Failure Averina, Stylidis, Brox, Schirmer. NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population. ESC Heart Failure. 2022 FRIDAID 2016466 doi:10.1002/ehf2.13906 2055-5822 https://hdl.handle.net/10037/25122 openAccess Copyright 2022 The Author(s) Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2022 ftunivtroemsoe https://doi.org/10.1002/ehf2.13906 2022-05-18T23:02:56Z Aims The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population. Methods and results Altogether, 1936 participants were randomly selected from the general population Tromsø 7 study in Northern Norway. Diagnostic accuracy (sensitivity, specificity, and negative and positive predictive value) of cardiac markers for echocardiographically defined subclinical HF was evaluated. The receiver-operating characteristic analysis showed that areas under the curve were relatively low (under 0.75) for both NT-proBNP and hs-troponin T, suggesting that the diagnostic accuracy of these biomarkers for subclinical HF was not excellent, especially for mild forms of HF and younger age group 40–49 years. Sex-specific and age-specific cut-offs for hs-troponin T (99th percentiles) and NT-proBNP (97.5th percentiles) were established in healthy subjects from the same general population. The sex-specific and age-specific cut-offs for NT-proBNP had higher specificity for subclinical HF compared with the previously established single cut-off 125 pg/mL. Age-specific cut-off for hs-troponin T (18 ng/L) for men ≥60 years had also higher specificity than the single cut-off 14 ng/L. These cut-offs had high specificity, but low sensitivity, that makes hs-troponin T and NT-proBNP good biomarkers to rule in HF in case of a positive test, but not good enough to rule out all unrecognized HF due to false negative results. Conclusions N-terminal pro-brain natriuretic peptide and hs-troponin T are suboptimal screening tools for subclinical HF in a general population due to low sensitivity. Article in Journal/Newspaper Northern Norway Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø ESC Heart Failure 9 3 1954 1962 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
description |
Aims The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population. Methods and results Altogether, 1936 participants were randomly selected from the general population Tromsø 7 study in Northern Norway. Diagnostic accuracy (sensitivity, specificity, and negative and positive predictive value) of cardiac markers for echocardiographically defined subclinical HF was evaluated. The receiver-operating characteristic analysis showed that areas under the curve were relatively low (under 0.75) for both NT-proBNP and hs-troponin T, suggesting that the diagnostic accuracy of these biomarkers for subclinical HF was not excellent, especially for mild forms of HF and younger age group 40–49 years. Sex-specific and age-specific cut-offs for hs-troponin T (99th percentiles) and NT-proBNP (97.5th percentiles) were established in healthy subjects from the same general population. The sex-specific and age-specific cut-offs for NT-proBNP had higher specificity for subclinical HF compared with the previously established single cut-off 125 pg/mL. Age-specific cut-off for hs-troponin T (18 ng/L) for men ≥60 years had also higher specificity than the single cut-off 14 ng/L. These cut-offs had high specificity, but low sensitivity, that makes hs-troponin T and NT-proBNP good biomarkers to rule in HF in case of a positive test, but not good enough to rule out all unrecognized HF due to false negative results. Conclusions N-terminal pro-brain natriuretic peptide and hs-troponin T are suboptimal screening tools for subclinical HF in a general population due to low sensitivity. |
format |
Article in Journal/Newspaper |
author |
Averina, Maria Stylidis, Michael Brox, Jan Schirmer, Henrik |
spellingShingle |
Averina, Maria Stylidis, Michael Brox, Jan Schirmer, Henrik NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population |
author_facet |
Averina, Maria Stylidis, Michael Brox, Jan Schirmer, Henrik |
author_sort |
Averina, Maria |
title |
NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population |
title_short |
NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population |
title_full |
NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population |
title_fullStr |
NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population |
title_full_unstemmed |
NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population |
title_sort |
nt-probnp and high-sensitivity troponin t as screening tests for subclinical chronic heart failure in a general population |
publisher |
Wiley |
publishDate |
2022 |
url |
https://hdl.handle.net/10037/25122 https://doi.org/10.1002/ehf2.13906 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Northern Norway Tromsø |
genre_facet |
Northern Norway Tromsø |
op_relation |
ESC Heart Failure Averina, Stylidis, Brox, Schirmer. NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population. ESC Heart Failure. 2022 FRIDAID 2016466 doi:10.1002/ehf2.13906 2055-5822 https://hdl.handle.net/10037/25122 |
op_rights |
openAccess Copyright 2022 The Author(s) |
op_doi |
https://doi.org/10.1002/ehf2.13906 |
container_title |
ESC Heart Failure |
container_volume |
9 |
container_issue |
3 |
container_start_page |
1954 |
op_container_end_page |
1962 |
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1766145756388917248 |