Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries
Objectives To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). Methods We conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurr...
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ftunivtroemsoe:oai:munin.uit.no:10037/24930 2023-05-15T16:51:26+02:00 Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries Farioli, Andrea Straif, Kurt Brandi, Giovanni Curti, Stefania Kjærheim, Kristina Martinsen, Jan Ivar Sparen, Pär Tryggvadottir, Laufey Weiderpass, Elisabete Biasco, Guido Violante, Francesco Saverio Mattioli, Stefano Pukkala, Eero 2017-11-13 https://hdl.handle.net/10037/24930 https://doi.org/10.1136/oemed-2017-104603 eng eng BMJ Occupational and Environmental Medicine Farioli, Straif K, Brandi, Curti, Kjærheim KJ, Martinsen JI, Sparen P, Tryggvadottir L, Weiderpass E, Biasco, Violante, Mattioli S, Pukkala E. Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries. Occupational and Environmental Medicine. 2018;75(3):191-198 FRIDAID 1592722 doi:10.1136/oemed-2017-104603 1351-0711 1470-7926 https://hdl.handle.net/10037/24930 openAccess Copyright 2018 The Author(s) Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2017 ftunivtroemsoe https://doi.org/10.1136/oemed-2017-104603 2022-05-04T22:58:43Z Objectives To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). Methods We conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls. The cumulative exposure to asbestos (measured in fibres (f)/ ml × years) was assessed by applying the NOCCA jobexposure matrix to data on occupations collected during national population censuses (conducted in 1960, 1970, 1980/81 and 1990). Odds ratios (OR) and 95% CI were estimated using conditional logistic regression models adjusted by printing industry work. Results We observed an increasing risk of ICC with cumulative exposure to asbestos: never exposed, OR 1.0 (reference category); 0.1–4.9 f/mL × years, OR 1.1 (95% CI 0.9 to 1.3); 5.0–9.9 f/mL × years, OR 1.3 (95% CI 0.9 to 2.1); 10.0–14.9 f/mL × years, OR 1.6 (95% CI 1.0 to 2.5); ≥15.0 f/mL × years, OR 1.7 (95% CI 1.1 to 2.6). We did not observe an association between cumulative asbestos exposure and ECC. Conclusions Our study provides evidence that exposure to asbestos might be a risk factor for ICC. Our findings also suggest that the association between ECC and asbestos is null or weaker than that observed for ICC. Further studies based on large industrial cohorts of asbestos workers and possibly accounting for personal characteristics and clinical history are needed. Article in Journal/Newspaper Iceland University of Tromsø: Munin Open Research Archive Norway Occupational and Environmental Medicine 75 3 191 198 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
description |
Objectives To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). Methods We conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls. The cumulative exposure to asbestos (measured in fibres (f)/ ml × years) was assessed by applying the NOCCA jobexposure matrix to data on occupations collected during national population censuses (conducted in 1960, 1970, 1980/81 and 1990). Odds ratios (OR) and 95% CI were estimated using conditional logistic regression models adjusted by printing industry work. Results We observed an increasing risk of ICC with cumulative exposure to asbestos: never exposed, OR 1.0 (reference category); 0.1–4.9 f/mL × years, OR 1.1 (95% CI 0.9 to 1.3); 5.0–9.9 f/mL × years, OR 1.3 (95% CI 0.9 to 2.1); 10.0–14.9 f/mL × years, OR 1.6 (95% CI 1.0 to 2.5); ≥15.0 f/mL × years, OR 1.7 (95% CI 1.1 to 2.6). We did not observe an association between cumulative asbestos exposure and ECC. Conclusions Our study provides evidence that exposure to asbestos might be a risk factor for ICC. Our findings also suggest that the association between ECC and asbestos is null or weaker than that observed for ICC. Further studies based on large industrial cohorts of asbestos workers and possibly accounting for personal characteristics and clinical history are needed. |
format |
Article in Journal/Newspaper |
author |
Farioli, Andrea Straif, Kurt Brandi, Giovanni Curti, Stefania Kjærheim, Kristina Martinsen, Jan Ivar Sparen, Pär Tryggvadottir, Laufey Weiderpass, Elisabete Biasco, Guido Violante, Francesco Saverio Mattioli, Stefano Pukkala, Eero |
spellingShingle |
Farioli, Andrea Straif, Kurt Brandi, Giovanni Curti, Stefania Kjærheim, Kristina Martinsen, Jan Ivar Sparen, Pär Tryggvadottir, Laufey Weiderpass, Elisabete Biasco, Guido Violante, Francesco Saverio Mattioli, Stefano Pukkala, Eero Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries |
author_facet |
Farioli, Andrea Straif, Kurt Brandi, Giovanni Curti, Stefania Kjærheim, Kristina Martinsen, Jan Ivar Sparen, Pär Tryggvadottir, Laufey Weiderpass, Elisabete Biasco, Guido Violante, Francesco Saverio Mattioli, Stefano Pukkala, Eero |
author_sort |
Farioli, Andrea |
title |
Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries |
title_short |
Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries |
title_full |
Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries |
title_fullStr |
Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries |
title_full_unstemmed |
Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries |
title_sort |
occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case-control study in four nordic countries |
publisher |
BMJ |
publishDate |
2017 |
url |
https://hdl.handle.net/10037/24930 https://doi.org/10.1136/oemed-2017-104603 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Occupational and Environmental Medicine Farioli, Straif K, Brandi, Curti, Kjærheim KJ, Martinsen JI, Sparen P, Tryggvadottir L, Weiderpass E, Biasco, Violante, Mattioli S, Pukkala E. Occupational exposure to asbestos and risk of cholangiocarcinoma: A population-based case-control study in four Nordic countries. Occupational and Environmental Medicine. 2018;75(3):191-198 FRIDAID 1592722 doi:10.1136/oemed-2017-104603 1351-0711 1470-7926 https://hdl.handle.net/10037/24930 |
op_rights |
openAccess Copyright 2018 The Author(s) |
op_doi |
https://doi.org/10.1136/oemed-2017-104603 |
container_title |
Occupational and Environmental Medicine |
container_volume |
75 |
container_issue |
3 |
container_start_page |
191 |
op_container_end_page |
198 |
_version_ |
1766041544750530560 |