The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection
The intraperitoneal route is favored for administration of inactivated and attenuated vaccines in Atlantic salmon. Nevertheless, the immune responses in the teleost peritoneal cavity (PerC) are still incompletely defined. In this study, we investigated the B cell responses after intraperitoneal Pisc...
Published in: | Developmental & Comparative Immunology |
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2021
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Online Access: | https://hdl.handle.net/10037/23810 https://doi.org/10.1016/j.dci.2021.104125 |
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ftunivtroemsoe:oai:munin.uit.no:10037/23810 2023-05-15T15:30:10+02:00 The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection van der Wal, Yorick Andreas Jenberie, Shiferaw Nordli, Henriette Greiner-Tollersrud, Linn Kool, Jaap Jensen, Ingvill Jørgensen, Jorunn 2021-06-01 https://hdl.handle.net/10037/23810 https://doi.org/10.1016/j.dci.2021.104125 eng eng Elsevier van der Wal, Y.A. (2023). Atlantic salmon immune responses after infection with intracellular pathogens. (Doctoral thesis). https://hdl.handle.net/10037/28518 . Developmental and Comparative Immunology van der Wal, Jenberie, Nordli, Greiner-Tollersrud, Kool, Jensen, Jørgensen. The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection. Developmental and Comparative Immunology. 2021;123 FRIDAID 1970494 doi:10.1016/j.dci.2021.104125 0145-305X 1879-0089 https://hdl.handle.net/10037/23810 openAccess Copyright 2021 The Author(s) Journal article Tidsskriftartikkel Peer reviewed acceptedVersion 2021 ftunivtroemsoe https://doi.org/10.1016/j.dci.2021.104125 2023-02-09T00:03:55Z The intraperitoneal route is favored for administration of inactivated and attenuated vaccines in Atlantic salmon. Nevertheless, the immune responses in the teleost peritoneal cavity (PerC) are still incompletely defined. In this study, we investigated the B cell responses after intraperitoneal Piscirickettsia salmonis (P. salmonis) challenge of Atlantic salmon, focusing on the local PerC response versus responses in the lymphatic organs: spleen and head kidney. We observed a major increase of leukocytes, total IgM antibody secreting cells (ASC), and P. salmonis-specific ASC in the PerC at 3- and 6-weeks post infection (wpi). The increase in ASC frequency was more prominent in the spleen and PerC compared to the head kidney during the observed 6 wpi. The serum antibody response included P. salmonis-specific antibodies and non-specific antibodies recognizing the non-related bacterial pathogen Yersinia ruckeri and the model antigen TNP-KLH. Finally, we present evidence that supports a putative role for the adipose tissue in the PerC immune response. Article in Journal/Newspaper Atlantic salmon University of Tromsø: Munin Open Research Archive Developmental & Comparative Immunology 123 104125 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
description |
The intraperitoneal route is favored for administration of inactivated and attenuated vaccines in Atlantic salmon. Nevertheless, the immune responses in the teleost peritoneal cavity (PerC) are still incompletely defined. In this study, we investigated the B cell responses after intraperitoneal Piscirickettsia salmonis (P. salmonis) challenge of Atlantic salmon, focusing on the local PerC response versus responses in the lymphatic organs: spleen and head kidney. We observed a major increase of leukocytes, total IgM antibody secreting cells (ASC), and P. salmonis-specific ASC in the PerC at 3- and 6-weeks post infection (wpi). The increase in ASC frequency was more prominent in the spleen and PerC compared to the head kidney during the observed 6 wpi. The serum antibody response included P. salmonis-specific antibodies and non-specific antibodies recognizing the non-related bacterial pathogen Yersinia ruckeri and the model antigen TNP-KLH. Finally, we present evidence that supports a putative role for the adipose tissue in the PerC immune response. |
format |
Article in Journal/Newspaper |
author |
van der Wal, Yorick Andreas Jenberie, Shiferaw Nordli, Henriette Greiner-Tollersrud, Linn Kool, Jaap Jensen, Ingvill Jørgensen, Jorunn |
spellingShingle |
van der Wal, Yorick Andreas Jenberie, Shiferaw Nordli, Henriette Greiner-Tollersrud, Linn Kool, Jaap Jensen, Ingvill Jørgensen, Jorunn The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection |
author_facet |
van der Wal, Yorick Andreas Jenberie, Shiferaw Nordli, Henriette Greiner-Tollersrud, Linn Kool, Jaap Jensen, Ingvill Jørgensen, Jorunn |
author_sort |
van der Wal, Yorick Andreas |
title |
The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection |
title_short |
The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection |
title_full |
The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection |
title_fullStr |
The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection |
title_full_unstemmed |
The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection |
title_sort |
importance of the atlantic salmon peritoneal cavity b cell response: local igm secreting cells are predominant upon piscirickettsia salmonis infection |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://hdl.handle.net/10037/23810 https://doi.org/10.1016/j.dci.2021.104125 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
van der Wal, Y.A. (2023). Atlantic salmon immune responses after infection with intracellular pathogens. (Doctoral thesis). https://hdl.handle.net/10037/28518 . Developmental and Comparative Immunology van der Wal, Jenberie, Nordli, Greiner-Tollersrud, Kool, Jensen, Jørgensen. The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection. Developmental and Comparative Immunology. 2021;123 FRIDAID 1970494 doi:10.1016/j.dci.2021.104125 0145-305X 1879-0089 https://hdl.handle.net/10037/23810 |
op_rights |
openAccess Copyright 2021 The Author(s) |
op_doi |
https://doi.org/10.1016/j.dci.2021.104125 |
container_title |
Developmental & Comparative Immunology |
container_volume |
123 |
container_start_page |
104125 |
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1766360619464785920 |