Plasma procoagulant phospholipid clotting time and venous thromboembolism risk
Background - Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles. No previous study has investigated the association between plasma procoagulant phospholipid clotting time (PPL...
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ftunivtroemsoe:oai:munin.uit.no:10037/23804 2023-05-15T18:34:45+02:00 Plasma procoagulant phospholipid clotting time and venous thromboembolism risk Ramberg, Cathrine Wilsgård, line Latysheva, Nadezhda Brækkan, Sigrid Kufaas Hindberg, Kristian Sovershaev, Timofey Snir, Omri Hansen, John Bjarne 2021-12-20 https://hdl.handle.net/10037/23804 https://doi.org/10.1002/rth2.12640 eng eng Wiley Research and Practice in Thrombosis and Haemostasis Ramberg, Wilsgård, Latysheva, Brækkan, Hindberg, Sovershaev, Snir, Hansen. Plasma procoagulant phospholipid clotting time and venous thromboembolism risk. Research and Practice in Thrombosis and Haemostasis. 2021;5(8):1-9 FRIDAID 1987100 doi:10.1002/rth2.12640 2475-0379 https://hdl.handle.net/10037/23804 openAccess Copyright 2021 The Author(s) Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2021 ftunivtroemsoe https://doi.org/10.1002/rth2.12640 2022-01-26T23:57:05Z Background - Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles. No previous study has investigated the association between plasma procoagulant phospholipid clotting time (PPL CT ) and future risk of venous thromboembolism (VTE). Objectives - To investigate the association between plasma PPL CT and the risk of incident VTE in a nested case-control study. Methods - We conducted a nested case-control study in 296 VTE patients and 674 age- and sex-matched controls derived from a general population cohort (The Tromsø Study 1994–2007). PPL CT was measured in platelet-free plasma using a modified factor Xa-dependent clotting assay. Logistic regression was used to estimate odds ratio (OR) with 95% confidence intervals (CI) for VTE with PPL CT modelled as a continuous variable across quartiles and in dichotomized analyses. Results - There was a weak inverse association between plasma PPL CT and risk of VTE per 1 standard deviation increase of PPL CT (OR 0.93, 95% CI 0.80–1.07) and when comparing those with PPL CT in the highest quartile (OR 0.89, 95% CI 0.60–1.30) with those in the lowest quartile. Subjects with PPL CT >95th percentile had substantially lowered OR for VTE (OR 0.35, 95% CI 0.13–0.81). The inverse association was stronger when the analyses were restricted to samples taken shortly before the event. The risk estimates by categories of plasma PPL CT were similar for deep vein thrombosis and pulmonary embolism. Conclusion - Our findings suggest that high plasma PPL CT is associated with reduced risk of VTE. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Research and Practice in Thrombosis and Haemostasis 5 8 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
description |
Background - Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles. No previous study has investigated the association between plasma procoagulant phospholipid clotting time (PPL CT ) and future risk of venous thromboembolism (VTE). Objectives - To investigate the association between plasma PPL CT and the risk of incident VTE in a nested case-control study. Methods - We conducted a nested case-control study in 296 VTE patients and 674 age- and sex-matched controls derived from a general population cohort (The Tromsø Study 1994–2007). PPL CT was measured in platelet-free plasma using a modified factor Xa-dependent clotting assay. Logistic regression was used to estimate odds ratio (OR) with 95% confidence intervals (CI) for VTE with PPL CT modelled as a continuous variable across quartiles and in dichotomized analyses. Results - There was a weak inverse association between plasma PPL CT and risk of VTE per 1 standard deviation increase of PPL CT (OR 0.93, 95% CI 0.80–1.07) and when comparing those with PPL CT in the highest quartile (OR 0.89, 95% CI 0.60–1.30) with those in the lowest quartile. Subjects with PPL CT >95th percentile had substantially lowered OR for VTE (OR 0.35, 95% CI 0.13–0.81). The inverse association was stronger when the analyses were restricted to samples taken shortly before the event. The risk estimates by categories of plasma PPL CT were similar for deep vein thrombosis and pulmonary embolism. Conclusion - Our findings suggest that high plasma PPL CT is associated with reduced risk of VTE. |
format |
Article in Journal/Newspaper |
author |
Ramberg, Cathrine Wilsgård, line Latysheva, Nadezhda Brækkan, Sigrid Kufaas Hindberg, Kristian Sovershaev, Timofey Snir, Omri Hansen, John Bjarne |
spellingShingle |
Ramberg, Cathrine Wilsgård, line Latysheva, Nadezhda Brækkan, Sigrid Kufaas Hindberg, Kristian Sovershaev, Timofey Snir, Omri Hansen, John Bjarne Plasma procoagulant phospholipid clotting time and venous thromboembolism risk |
author_facet |
Ramberg, Cathrine Wilsgård, line Latysheva, Nadezhda Brækkan, Sigrid Kufaas Hindberg, Kristian Sovershaev, Timofey Snir, Omri Hansen, John Bjarne |
author_sort |
Ramberg, Cathrine |
title |
Plasma procoagulant phospholipid clotting time and venous thromboembolism risk |
title_short |
Plasma procoagulant phospholipid clotting time and venous thromboembolism risk |
title_full |
Plasma procoagulant phospholipid clotting time and venous thromboembolism risk |
title_fullStr |
Plasma procoagulant phospholipid clotting time and venous thromboembolism risk |
title_full_unstemmed |
Plasma procoagulant phospholipid clotting time and venous thromboembolism risk |
title_sort |
plasma procoagulant phospholipid clotting time and venous thromboembolism risk |
publisher |
Wiley |
publishDate |
2021 |
url |
https://hdl.handle.net/10037/23804 https://doi.org/10.1002/rth2.12640 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Research and Practice in Thrombosis and Haemostasis Ramberg, Wilsgård, Latysheva, Brækkan, Hindberg, Sovershaev, Snir, Hansen. Plasma procoagulant phospholipid clotting time and venous thromboembolism risk. Research and Practice in Thrombosis and Haemostasis. 2021;5(8):1-9 FRIDAID 1987100 doi:10.1002/rth2.12640 2475-0379 https://hdl.handle.net/10037/23804 |
op_rights |
openAccess Copyright 2021 The Author(s) |
op_doi |
https://doi.org/10.1002/rth2.12640 |
container_title |
Research and Practice in Thrombosis and Haemostasis |
container_volume |
5 |
container_issue |
8 |
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1766219660715360256 |