Myelinated Retinal Nerve Fibre: Prevalence and its Association with Ocular and Systemic Parameters in Tromsø.

Background: Myelinated retinal nerve fibres (MRNFs) are congenital anomalies of the fundus that occur in about 1% of the population. Clinically, they appear as grey or white well-separated patches with feathery borders along the retinal nerve fibre layer. MRNF has been reported to occur in associati...

Full description

Bibliographic Details
Main Author: Kalu, Dominic Okoro
Format: Master Thesis
Language:English
Published: UiT Norges arktiske universitet 2020
Subjects:
Online Access:https://hdl.handle.net/10037/23208
id ftunivtroemsoe:oai:munin.uit.no:10037/23208
record_format openpolar
spelling ftunivtroemsoe:oai:munin.uit.no:10037/23208 2023-05-15T18:34:17+02:00 Myelinated Retinal Nerve Fibre: Prevalence and its Association with Ocular and Systemic Parameters in Tromsø. Kalu, Dominic Okoro 2020-11-30 https://hdl.handle.net/10037/23208 eng eng UiT Norges arktiske universitet UiT The Arctic University of Norway https://hdl.handle.net/10037/23208 Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 HEL-3950 Mastergradsoppgave Master thesis 2020 ftunivtroemsoe 2021-12-01T23:54:51Z Background: Myelinated retinal nerve fibres (MRNFs) are congenital anomalies of the fundus that occur in about 1% of the population. Clinically, they appear as grey or white well-separated patches with feathery borders along the retinal nerve fibre layer. MRNF has been reported to occur in association with some ocular parameters as well as stroke. However, most cases of MRNF occur in isolation and are asymptomatic. Purpose: To determine the prevalence, ocular and systemic associations of MRNF in Tromsø. Methods: The present study included 7396 participants aged 40–84 years from the Tromsø Eye Study, a sub-study of the population-based Tromsø Study in Norway. Data on ocular and systemic parameters were collected from self-report questionnaires, clinical examinations, and laboratory measurements. Retinal images from both eyes were assessed for the presence of MRNF. Logistic regression models were used to assess the association between MRNF and ocular and systemic parameters. Results: Readable fundus photographs of at least one eye were available in 7396 (88.0%) of 8346 participants of the Tromsø eye study (TES). The study cohort included 3979 (55.8%) females and 3417 (46.2%) males. The mean age in the whole study cohort was 62.9 ± 10.4 years with 62.8 ± 10.4 and 63.1 ± 10.4 years in females and males respectively. The prevalence of MRNF in the study sample was 1.1%. In a multivariable logistic regression analysis, MRNF was associated with male sex (OR, 1.785; 95% CI, 1.138–2.799; P, 0.012) and glycosylated haemoglobin (HbA1c) (OR, 0.559; 95%CL, 0.316 – 0.989; P, 0.046). MRNF was not associated with age, systemic conditions or ocular parameters such as visual acuity, refractive error, or intraocular pressure. Conclusion: This population-based study is the first to provide data on the prevalence of MRNF in the Nordic population. It is also the first study to report an association between MRNF and HbA1c, although this may be a chance finding and must be explored further. This study tends to affirm the general perception that MRNF is without serious clinical implications, however, this must also be investigated further in future studies. Master Thesis Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø
institution Open Polar
collection University of Tromsø: Munin Open Research Archive
op_collection_id ftunivtroemsoe
language English
topic VDP::Medical disciplines: 700::Clinical medical disciplines: 750
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750
HEL-3950
spellingShingle VDP::Medical disciplines: 700::Clinical medical disciplines: 750
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750
HEL-3950
Kalu, Dominic Okoro
Myelinated Retinal Nerve Fibre: Prevalence and its Association with Ocular and Systemic Parameters in Tromsø.
topic_facet VDP::Medical disciplines: 700::Clinical medical disciplines: 750
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750
HEL-3950
description Background: Myelinated retinal nerve fibres (MRNFs) are congenital anomalies of the fundus that occur in about 1% of the population. Clinically, they appear as grey or white well-separated patches with feathery borders along the retinal nerve fibre layer. MRNF has been reported to occur in association with some ocular parameters as well as stroke. However, most cases of MRNF occur in isolation and are asymptomatic. Purpose: To determine the prevalence, ocular and systemic associations of MRNF in Tromsø. Methods: The present study included 7396 participants aged 40–84 years from the Tromsø Eye Study, a sub-study of the population-based Tromsø Study in Norway. Data on ocular and systemic parameters were collected from self-report questionnaires, clinical examinations, and laboratory measurements. Retinal images from both eyes were assessed for the presence of MRNF. Logistic regression models were used to assess the association between MRNF and ocular and systemic parameters. Results: Readable fundus photographs of at least one eye were available in 7396 (88.0%) of 8346 participants of the Tromsø eye study (TES). The study cohort included 3979 (55.8%) females and 3417 (46.2%) males. The mean age in the whole study cohort was 62.9 ± 10.4 years with 62.8 ± 10.4 and 63.1 ± 10.4 years in females and males respectively. The prevalence of MRNF in the study sample was 1.1%. In a multivariable logistic regression analysis, MRNF was associated with male sex (OR, 1.785; 95% CI, 1.138–2.799; P, 0.012) and glycosylated haemoglobin (HbA1c) (OR, 0.559; 95%CL, 0.316 – 0.989; P, 0.046). MRNF was not associated with age, systemic conditions or ocular parameters such as visual acuity, refractive error, or intraocular pressure. Conclusion: This population-based study is the first to provide data on the prevalence of MRNF in the Nordic population. It is also the first study to report an association between MRNF and HbA1c, although this may be a chance finding and must be explored further. This study tends to affirm the general perception that MRNF is without serious clinical implications, however, this must also be investigated further in future studies.
format Master Thesis
author Kalu, Dominic Okoro
author_facet Kalu, Dominic Okoro
author_sort Kalu, Dominic Okoro
title Myelinated Retinal Nerve Fibre: Prevalence and its Association with Ocular and Systemic Parameters in Tromsø.
title_short Myelinated Retinal Nerve Fibre: Prevalence and its Association with Ocular and Systemic Parameters in Tromsø.
title_full Myelinated Retinal Nerve Fibre: Prevalence and its Association with Ocular and Systemic Parameters in Tromsø.
title_fullStr Myelinated Retinal Nerve Fibre: Prevalence and its Association with Ocular and Systemic Parameters in Tromsø.
title_full_unstemmed Myelinated Retinal Nerve Fibre: Prevalence and its Association with Ocular and Systemic Parameters in Tromsø.
title_sort myelinated retinal nerve fibre: prevalence and its association with ocular and systemic parameters in tromsø.
publisher UiT Norges arktiske universitet
publishDate 2020
url https://hdl.handle.net/10037/23208
geographic Norway
Tromsø
geographic_facet Norway
Tromsø
genre Tromsø
genre_facet Tromsø
op_relation https://hdl.handle.net/10037/23208
op_rights Copyright 2020 The Author(s)
_version_ 1766218961048829952