Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study.
Til opplæring (OA) LiseA Background: Chronic obstructive pulmonary disease (COPD) is associated with risk of venous thromboembolism (VTE). It remains unknown whether individual respiratory symptoms and lowered oxygen saturation (SpO 2 ), individually and in combination with COPD, affect the risk of...
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Online Access: | https://hdl.handle.net/10037/22644 https://doi.org/10.1002/rth2.12299 |
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ftunivtroemsoe:oai:munin.uit.no:10037/22644 2023-05-15T18:34:28+02:00 Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. Børvik, Trond Evensen, Line Morelli, Vania Maris Melbye, Hasse Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2020-01-09 https://hdl.handle.net/10037/22644 https://doi.org/10.1002/rth2.12299 eng eng Wiley Research and Practice in Thrombosis and Haemostasis Børvik T, Evensen L, Morelli VM, Melbye H, Brækkan SK, Hansen JB. Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. Research and Practice in Thrombosis and Haemostasis. 2020;4(2):255-262 FRIDAID 1892499 doi:10.1002/rth2.12299 2475-0379 https://hdl.handle.net/10037/22644 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1002/rth2.12299 2021-09-29T22:53:54Z Til opplæring (OA) LiseA Background: Chronic obstructive pulmonary disease (COPD) is associated with risk of venous thromboembolism (VTE). It remains unknown whether individual respiratory symptoms and lowered oxygen saturation (SpO 2 ), individually and in combination with COPD, affect the risk of VTE. Objectives: To investigate whether measures of respiratory impairments including respiratory symptoms and SpO 2 , individually and combined with COPD, were associated with an increased risk of VTE. Methods: Spirometry, SpO 2 , and self-reported respiratory symptoms were collected in 8686 participants from the fifth (2001-2002) and sixth (2007-2008) surveys of the Tromsø Study. Incident VTE events were registered from the date of inclusion to December 31, 2016. Cox regression models with exposures and confounders as time-varying covariates (for repeated measurements) were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for VTE. Results: During a median follow-up of 9.1 years, 330 participants developed incident VTE. Subjects with SpO 2 ≤ 96% (lowest 20th percentile) had a 1.5-fold higher risk of VTE (adjusted HR, 1.48; 95% CI, 1.13-1.93) compared with those with SpO 2 ≥ 98%. Severe respiratory symptoms (dyspnea, cough, and phlegm) were associated with a 1.4- to 2.0-fold higher risk of VTE compared with no such symptoms. COPD, combined with respiratory symptoms or lowered SpO 2 , had an additive effect on the VTE risk. Conclusions: Lowered SpO 2 and severe respiratory symptoms were associated with increased VTE risk. COPD combined with respiratory impairments had an additive effect on VTE risk, and may suggest particular attention on VTE preventive strategies in COPD patients with respiratory impairments. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Research and Practice in Thrombosis and Haemostasis 4 2 255 262 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
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VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Børvik, Trond Evensen, Line Morelli, Vania Maris Melbye, Hasse Brækkan, Sigrid Kufaas Hansen, John-Bjarne Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. |
topic_facet |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
description |
Til opplæring (OA) LiseA Background: Chronic obstructive pulmonary disease (COPD) is associated with risk of venous thromboembolism (VTE). It remains unknown whether individual respiratory symptoms and lowered oxygen saturation (SpO 2 ), individually and in combination with COPD, affect the risk of VTE. Objectives: To investigate whether measures of respiratory impairments including respiratory symptoms and SpO 2 , individually and combined with COPD, were associated with an increased risk of VTE. Methods: Spirometry, SpO 2 , and self-reported respiratory symptoms were collected in 8686 participants from the fifth (2001-2002) and sixth (2007-2008) surveys of the Tromsø Study. Incident VTE events were registered from the date of inclusion to December 31, 2016. Cox regression models with exposures and confounders as time-varying covariates (for repeated measurements) were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for VTE. Results: During a median follow-up of 9.1 years, 330 participants developed incident VTE. Subjects with SpO 2 ≤ 96% (lowest 20th percentile) had a 1.5-fold higher risk of VTE (adjusted HR, 1.48; 95% CI, 1.13-1.93) compared with those with SpO 2 ≥ 98%. Severe respiratory symptoms (dyspnea, cough, and phlegm) were associated with a 1.4- to 2.0-fold higher risk of VTE compared with no such symptoms. COPD, combined with respiratory symptoms or lowered SpO 2 , had an additive effect on the VTE risk. Conclusions: Lowered SpO 2 and severe respiratory symptoms were associated with increased VTE risk. COPD combined with respiratory impairments had an additive effect on VTE risk, and may suggest particular attention on VTE preventive strategies in COPD patients with respiratory impairments. |
format |
Article in Journal/Newspaper |
author |
Børvik, Trond Evensen, Line Morelli, Vania Maris Melbye, Hasse Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Børvik, Trond Evensen, Line Morelli, Vania Maris Melbye, Hasse Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Børvik, Trond |
title |
Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. |
title_short |
Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. |
title_full |
Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. |
title_fullStr |
Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. |
title_full_unstemmed |
Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. |
title_sort |
impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the tromsø study. |
publisher |
Wiley |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/22644 https://doi.org/10.1002/rth2.12299 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Research and Practice in Thrombosis and Haemostasis Børvik T, Evensen L, Morelli VM, Melbye H, Brækkan SK, Hansen JB. Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. Research and Practice in Thrombosis and Haemostasis. 2020;4(2):255-262 FRIDAID 1892499 doi:10.1002/rth2.12299 2475-0379 https://hdl.handle.net/10037/22644 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1002/rth2.12299 |
container_title |
Research and Practice in Thrombosis and Haemostasis |
container_volume |
4 |
container_issue |
2 |
container_start_page |
255 |
op_container_end_page |
262 |
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