What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity
Introduction - Compared with many other countries Russia has a high prevalence of diabetes in men and women. However, contrary to what is found in most other populations, the risk is greater among women than men. The reasons for this are unclear. Research design and methods - Prevalence and risk fac...
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Online Access: | https://hdl.handle.net/10037/22443 https://doi.org/10.1136/bmjdrc-2020-002021 |
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ftunivtroemsoe:oai:munin.uit.no:10037/22443 2023-05-15T18:34:17+02:00 What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity Iakunchykova, Olena Averina, Maria Wilsgaard, Tom Malyutina, Sofia Kudryavtsev, Alexander V Cook, Sarah Wild, Sarah Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David A. 2021-03-04 https://hdl.handle.net/10037/22443 https://doi.org/10.1136/bmjdrc-2020-002021 eng eng BMJ Publishing Group BMJ Open Diabetes Research & Care Iakunchykova, Averina, Wilsgaard, Malyutina, Kudryavtsev, Cook, Wild, Eggen, Hopstock, Leon. What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity. BMJ Open Diabetes Research & Care. 2021;9(1) FRIDAID 1918557 doi:10.1136/bmjdrc-2020-002021 2052-4897 https://hdl.handle.net/10037/22443 openAccess Copyright 2021 The Author(s) VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2021 ftunivtroemsoe https://doi.org/10.1136/bmjdrc-2020-002021 2021-09-08T22:53:43Z Introduction - Compared with many other countries Russia has a high prevalence of diabetes in men and women. However, contrary to what is found in most other populations, the risk is greater among women than men. The reasons for this are unclear. Research design and methods - Prevalence and risk factors for diabetes at ages 40–69 years were compared in two population-based studies: Know Your Heart (KYH) (Russia, 2015–2018, n=4121) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2016, n=17 649). Diabetes was defined by the level of glycated hemoglobin and/or self-reported diabetes and/or diabetes medication use. Marginal structural models were used to estimate the role of key risk factors for diabetes in differences between the studies. Results - Age-standardized prevalence of diabetes was higher in KYH compared with Tromsø 7 in men (11.6% vs 6.2%) and in women (13.2% vs 4.3%). Age-adjusted ORs for diabetes in KYH compared with Tromsø 7 were 2.01 (95% CI 1.68 to 2.40) for men and 3.66 (95% CI 3.13 to 4.26) for women. Adiposity (body mass index and waist circumference) explained none of this effect for men but explained 46.0% (39.6, 53.8) for women. Addition of smoking and C reactive protein, as further mediators, slightly increased the percentage explained of the difference between studies to 55.5% (46.5, 66.0) for women but only to 9.9% (−0.6, 20.8) for men. Conclusions - Adiposity is a key modifiable risk factor that appears to explain half of the almost threefold higher female prevalence of diabetes in Russia compared with Norway, but none of the twofold male difference. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø BMJ Open Diabetes Research & Care 9 1 e002021 |
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Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
spellingShingle |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Iakunchykova, Olena Averina, Maria Wilsgaard, Tom Malyutina, Sofia Kudryavtsev, Alexander V Cook, Sarah Wild, Sarah Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David A. What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity |
topic_facet |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
description |
Introduction - Compared with many other countries Russia has a high prevalence of diabetes in men and women. However, contrary to what is found in most other populations, the risk is greater among women than men. The reasons for this are unclear. Research design and methods - Prevalence and risk factors for diabetes at ages 40–69 years were compared in two population-based studies: Know Your Heart (KYH) (Russia, 2015–2018, n=4121) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2016, n=17 649). Diabetes was defined by the level of glycated hemoglobin and/or self-reported diabetes and/or diabetes medication use. Marginal structural models were used to estimate the role of key risk factors for diabetes in differences between the studies. Results - Age-standardized prevalence of diabetes was higher in KYH compared with Tromsø 7 in men (11.6% vs 6.2%) and in women (13.2% vs 4.3%). Age-adjusted ORs for diabetes in KYH compared with Tromsø 7 were 2.01 (95% CI 1.68 to 2.40) for men and 3.66 (95% CI 3.13 to 4.26) for women. Adiposity (body mass index and waist circumference) explained none of this effect for men but explained 46.0% (39.6, 53.8) for women. Addition of smoking and C reactive protein, as further mediators, slightly increased the percentage explained of the difference between studies to 55.5% (46.5, 66.0) for women but only to 9.9% (−0.6, 20.8) for men. Conclusions - Adiposity is a key modifiable risk factor that appears to explain half of the almost threefold higher female prevalence of diabetes in Russia compared with Norway, but none of the twofold male difference. |
format |
Article in Journal/Newspaper |
author |
Iakunchykova, Olena Averina, Maria Wilsgaard, Tom Malyutina, Sofia Kudryavtsev, Alexander V Cook, Sarah Wild, Sarah Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David A. |
author_facet |
Iakunchykova, Olena Averina, Maria Wilsgaard, Tom Malyutina, Sofia Kudryavtsev, Alexander V Cook, Sarah Wild, Sarah Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David A. |
author_sort |
Iakunchykova, Olena |
title |
What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity |
title_short |
What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity |
title_full |
What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity |
title_fullStr |
What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity |
title_full_unstemmed |
What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity |
title_sort |
what factors explain the much higher diabetes prevalence in russia compared with norway? major sex differences in the contribution of adiposity |
publisher |
BMJ Publishing Group |
publishDate |
2021 |
url |
https://hdl.handle.net/10037/22443 https://doi.org/10.1136/bmjdrc-2020-002021 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMJ Open Diabetes Research & Care Iakunchykova, Averina, Wilsgaard, Malyutina, Kudryavtsev, Cook, Wild, Eggen, Hopstock, Leon. What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity. BMJ Open Diabetes Research & Care. 2021;9(1) FRIDAID 1918557 doi:10.1136/bmjdrc-2020-002021 2052-4897 https://hdl.handle.net/10037/22443 |
op_rights |
openAccess Copyright 2021 The Author(s) |
op_doi |
https://doi.org/10.1136/bmjdrc-2020-002021 |
container_title |
BMJ Open Diabetes Research & Care |
container_volume |
9 |
container_issue |
1 |
container_start_page |
e002021 |
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1766218972076703744 |