Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population
Objective: Staphylococcus aureus is a major human pathogen, and nasal carriers have an increased risk for infection and disease. The exploration of host determinants for nasal carriage is relevant to decrease infection burden. Former studies demonstrate lower carriage prevalence in women and among u...
Published in: | European Journal of Endocrinology |
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Language: | English |
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European Society of Endocrinology
2021
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Online Access: | https://hdl.handle.net/10037/21942 https://doi.org/10.1530/EJE-20-0877 |
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ftunivtroemsoe:oai:munin.uit.no:10037/21942 2023-05-15T18:34:31+02:00 Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population Stensen, Dina Benedicte Berg Småbrekke, Lars Olsen, Karina Grimnes, Guri Nielsen, Christopher Sivert Sollid, Johanna U Ericson Simonsen, Gunnar Skov Almås, Bjørg Furberg, Anne-Sofie 2021-02 https://hdl.handle.net/10037/21942 https://doi.org/10.1530/EJE-20-0877 eng eng European Society of Endocrinology Stensen, D.B.B. (2022). Sex-steroids and social network in relation to Staphylococcus aureus nasal carriage. (Doctoral thesis). https://hdl.handle.net/10037/24401 . European Journal of Endocrinology https://doi.org/10.1530/EJE-20-0877 Stensen, Småbrekke, Olsen, Grimnes, Nielsen, Sollid, Simonsen, Almås, Furberg. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population. European Journal of Endocrinology. 2021;184(2):337-346 FRIDAID 1896577 doi:10.1530/EJE-20-0877 0804-4643 1479-683X https://hdl.handle.net/10037/21942 openAccess Copyright 2021 The Author(s) VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 The Tromsø Study Tromsøundersøkelsen Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2021 ftunivtroemsoe https://doi.org/10.1530/EJE-20-0877 2022-03-16T23:58:04Z Objective: Staphylococcus aureus is a major human pathogen, and nasal carriers have an increased risk for infection and disease. The exploration of host determinants for nasal carriage is relevant to decrease infection burden. Former studies demonstrate lower carriage prevalence in women and among users of progestin-only contraceptives. The aim of this study was to investigate the possible associations between circulating sex-steroid hormones and nasal carriage of Staphylococcus aureus in a general population. Methods: In the population-based sixth Tromsø study (2007–2008) nurses collected nasal swab samples from 724 women aged 30–87 not using any exogenous hormones, and 700 of the women had a repeated nasal swab taken (median interval 28 days). We analysed a panel of serum sex-steroids by liquid chromatography tandem mass spectrometry, and collected information about lifestyle, health and anthropometric measures. Multivariable logistic regression was used to study the association between circulating sex-steroids and Staphylococcus aureus carriage (one swab) and persistent carriage (two swabs), while adjusting for potential confounding factors. Women in luteal phase were excluded in the analysis of androgens. Results: Staphylococcus aureus persistent nasal carriage prevalence was 22%. One standard deviation increase in testosterone and bioavailable testosterone was associated with lower odds of persistent nasal carriage, (OR = 0.57; 95% CI = 0.35–0.92 and OR = 0.52, 95% CI = 0.30–0.92) respectively. Analysis stratified by menopause gave similar findings. Persistent carriers had lower average levels of androstenedione and DHEA, however, not statistically significant. Conclusion: This large population-based study supports that women with lower levels of circulating testosterone may have increased probability of Staphylococcus aureus persistent carriage. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø European Journal of Endocrinology 184 2 337 346 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 The Tromsø Study Tromsøundersøkelsen |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 The Tromsø Study Tromsøundersøkelsen Stensen, Dina Benedicte Berg Småbrekke, Lars Olsen, Karina Grimnes, Guri Nielsen, Christopher Sivert Sollid, Johanna U Ericson Simonsen, Gunnar Skov Almås, Bjørg Furberg, Anne-Sofie Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 The Tromsø Study Tromsøundersøkelsen |
description |
Objective: Staphylococcus aureus is a major human pathogen, and nasal carriers have an increased risk for infection and disease. The exploration of host determinants for nasal carriage is relevant to decrease infection burden. Former studies demonstrate lower carriage prevalence in women and among users of progestin-only contraceptives. The aim of this study was to investigate the possible associations between circulating sex-steroid hormones and nasal carriage of Staphylococcus aureus in a general population. Methods: In the population-based sixth Tromsø study (2007–2008) nurses collected nasal swab samples from 724 women aged 30–87 not using any exogenous hormones, and 700 of the women had a repeated nasal swab taken (median interval 28 days). We analysed a panel of serum sex-steroids by liquid chromatography tandem mass spectrometry, and collected information about lifestyle, health and anthropometric measures. Multivariable logistic regression was used to study the association between circulating sex-steroids and Staphylococcus aureus carriage (one swab) and persistent carriage (two swabs), while adjusting for potential confounding factors. Women in luteal phase were excluded in the analysis of androgens. Results: Staphylococcus aureus persistent nasal carriage prevalence was 22%. One standard deviation increase in testosterone and bioavailable testosterone was associated with lower odds of persistent nasal carriage, (OR = 0.57; 95% CI = 0.35–0.92 and OR = 0.52, 95% CI = 0.30–0.92) respectively. Analysis stratified by menopause gave similar findings. Persistent carriers had lower average levels of androstenedione and DHEA, however, not statistically significant. Conclusion: This large population-based study supports that women with lower levels of circulating testosterone may have increased probability of Staphylococcus aureus persistent carriage. |
format |
Article in Journal/Newspaper |
author |
Stensen, Dina Benedicte Berg Småbrekke, Lars Olsen, Karina Grimnes, Guri Nielsen, Christopher Sivert Sollid, Johanna U Ericson Simonsen, Gunnar Skov Almås, Bjørg Furberg, Anne-Sofie |
author_facet |
Stensen, Dina Benedicte Berg Småbrekke, Lars Olsen, Karina Grimnes, Guri Nielsen, Christopher Sivert Sollid, Johanna U Ericson Simonsen, Gunnar Skov Almås, Bjørg Furberg, Anne-Sofie |
author_sort |
Stensen, Dina Benedicte Berg |
title |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_short |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_full |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_fullStr |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_full_unstemmed |
Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population |
title_sort |
circulating sex-steroids and staphylococcus aureus nasal carriage in a general female population |
publisher |
European Society of Endocrinology |
publishDate |
2021 |
url |
https://hdl.handle.net/10037/21942 https://doi.org/10.1530/EJE-20-0877 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Stensen, D.B.B. (2022). Sex-steroids and social network in relation to Staphylococcus aureus nasal carriage. (Doctoral thesis). https://hdl.handle.net/10037/24401 . European Journal of Endocrinology https://doi.org/10.1530/EJE-20-0877 Stensen, Småbrekke, Olsen, Grimnes, Nielsen, Sollid, Simonsen, Almås, Furberg. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population. European Journal of Endocrinology. 2021;184(2):337-346 FRIDAID 1896577 doi:10.1530/EJE-20-0877 0804-4643 1479-683X https://hdl.handle.net/10037/21942 |
op_rights |
openAccess Copyright 2021 The Author(s) |
op_doi |
https://doi.org/10.1530/EJE-20-0877 |
container_title |
European Journal of Endocrinology |
container_volume |
184 |
container_issue |
2 |
container_start_page |
337 |
op_container_end_page |
346 |
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1766219297450885120 |