Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study
Background - High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a...
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ftunivtroemsoe:oai:munin.uit.no:10037/21772 2023-05-15T18:34:28+02:00 Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study Bekkelund, Svein Ivar 2021-01-13 https://hdl.handle.net/10037/21772 https://doi.org/10.1186/s12872-020-01826-1 eng eng BMC BMC Cardiovascular Disorders Bekkelund. Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study. BMC Cardiovascular Disorders. 2021;21(1):1-7 FRIDAID 1905133 doi:10.1186/s12872-020-01826-1 1471-2261 https://hdl.handle.net/10037/21772 Copyright 2021 The Author(s) VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2021 ftunivtroemsoe https://doi.org/10.1186/s12872-020-01826-1 2021-07-07T22:52:36Z Background - High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population. Methods - Cross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromsø 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP). Results - Abnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88–1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86–0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found. Conclusion - This study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø BMC Cardiovascular Disorders 21 1 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 |
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VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 Bekkelund, Svein Ivar Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
topic_facet |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 |
description |
Background - High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population. Methods - Cross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromsø 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP). Results - Abnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88–1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86–0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found. Conclusion - This study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies. |
format |
Article in Journal/Newspaper |
author |
Bekkelund, Svein Ivar |
author_facet |
Bekkelund, Svein Ivar |
author_sort |
Bekkelund, Svein Ivar |
title |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_short |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_full |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_fullStr |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_full_unstemmed |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_sort |
serum alanine aminotransferase activity and risk factors for cardiovascular disease in a caucasian population: the tromsø study |
publisher |
BMC |
publishDate |
2021 |
url |
https://hdl.handle.net/10037/21772 https://doi.org/10.1186/s12872-020-01826-1 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMC Cardiovascular Disorders Bekkelund. Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study. BMC Cardiovascular Disorders. 2021;21(1):1-7 FRIDAID 1905133 doi:10.1186/s12872-020-01826-1 1471-2261 https://hdl.handle.net/10037/21772 |
op_rights |
Copyright 2021 The Author(s) |
op_doi |
https://doi.org/10.1186/s12872-020-01826-1 |
container_title |
BMC Cardiovascular Disorders |
container_volume |
21 |
container_issue |
1 |
_version_ |
1766219224479432704 |