A possible effect of montelukast on neurological aging examined by the use of register data
Background - The leukotriene receptor antagonist montelukast has been shown to rejuvenate aged brains in rats; however, data on humans are still scarce. Objective To investigate if montelukast may alleviate degenerative neurological changes using a register data. Setting Norwegian registry data anal...
Published in: | International Journal of Clinical Pharmacy |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Springer
2020
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/20866 https://doi.org/10.1007/s11096-020-01160-8 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/20866 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/20866 2023-05-15T18:34:41+02:00 A possible effect of montelukast on neurological aging examined by the use of register data Grinde, Bjørn Schirmer, Henrik Eggen, Anne Elise Aigner, Ludwig Engdahl, Bo Lars 2020-10-09 https://hdl.handle.net/10037/20866 https://doi.org/10.1007/s11096-020-01160-8 eng eng Springer International Journal of Clinical Pharmacy FRIDAID 1873478 doi:10.1007/s11096-020-01160-8 2210-7703 2210-7711 https://hdl.handle.net/10037/20866 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1007/s11096-020-01160-8 2021-06-25T17:58:00Z Background - The leukotriene receptor antagonist montelukast has been shown to rejuvenate aged brains in rats; however, data on humans are still scarce. Objective To investigate if montelukast may alleviate degenerative neurological changes using a register data. Setting Norwegian registry data analyses. Method - The present observational study was based on data from the Norwegian Prescription Database and the Tromsø Study. The former has information regarding the use of prescription medicine; the latter includes tests for brain function such as subjective memory and finger-tapping. Multivariate linear regression analyses were performed to see how the use of various medications correlated with the test results, correcting for likely confounders. Main outcome measure - Results on seven different tests considered relevant for neurological health were used as outcome. Results Previous use of montelukast correlated with improved scores on cognitive or neurological functioning (F = 2.20, p = 0.03 in a multivariate test). A range of other medications were tested with the same algorithm, including drugs acting on the immune system, but none of them correlated with (overall) significantly improved test results. Conclusion - The present data suggest that montelukast may alleviate degenerative neurological changes associated with human aging. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø International Journal of Clinical Pharmacy 43 3 541 548 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Grinde, Bjørn Schirmer, Henrik Eggen, Anne Elise Aigner, Ludwig Engdahl, Bo Lars A possible effect of montelukast on neurological aging examined by the use of register data |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
description |
Background - The leukotriene receptor antagonist montelukast has been shown to rejuvenate aged brains in rats; however, data on humans are still scarce. Objective To investigate if montelukast may alleviate degenerative neurological changes using a register data. Setting Norwegian registry data analyses. Method - The present observational study was based on data from the Norwegian Prescription Database and the Tromsø Study. The former has information regarding the use of prescription medicine; the latter includes tests for brain function such as subjective memory and finger-tapping. Multivariate linear regression analyses were performed to see how the use of various medications correlated with the test results, correcting for likely confounders. Main outcome measure - Results on seven different tests considered relevant for neurological health were used as outcome. Results Previous use of montelukast correlated with improved scores on cognitive or neurological functioning (F = 2.20, p = 0.03 in a multivariate test). A range of other medications were tested with the same algorithm, including drugs acting on the immune system, but none of them correlated with (overall) significantly improved test results. Conclusion - The present data suggest that montelukast may alleviate degenerative neurological changes associated with human aging. |
format |
Article in Journal/Newspaper |
author |
Grinde, Bjørn Schirmer, Henrik Eggen, Anne Elise Aigner, Ludwig Engdahl, Bo Lars |
author_facet |
Grinde, Bjørn Schirmer, Henrik Eggen, Anne Elise Aigner, Ludwig Engdahl, Bo Lars |
author_sort |
Grinde, Bjørn |
title |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_short |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_full |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_fullStr |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_full_unstemmed |
A possible effect of montelukast on neurological aging examined by the use of register data |
title_sort |
possible effect of montelukast on neurological aging examined by the use of register data |
publisher |
Springer |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20866 https://doi.org/10.1007/s11096-020-01160-8 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
International Journal of Clinical Pharmacy FRIDAID 1873478 doi:10.1007/s11096-020-01160-8 2210-7703 2210-7711 https://hdl.handle.net/10037/20866 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1007/s11096-020-01160-8 |
container_title |
International Journal of Clinical Pharmacy |
container_volume |
43 |
container_issue |
3 |
container_start_page |
541 |
op_container_end_page |
548 |
_version_ |
1766219535922233344 |