Environmental pollutants in blood donors: The multicentre Norwegian donor study
Objectives - The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background - Transfused blood may be a potential source of exposure to heavy metals and organic pollutants an...
Published in: | Transfusion Medicine |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2020
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/20854 https://doi.org/10.1111/tme.12662 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/20854 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/20854 2023-05-15T17:03:59+02:00 Environmental pollutants in blood donors: The multicentre Norwegian donor study Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar Klæboe Bolann, Bjørn Johan 2020-01-11 https://hdl.handle.net/10037/20854 https://doi.org/10.1111/tme.12662 eng eng Wiley Transfusion Medicine Averina M, Hervig T, Huber SH, Kjær MK, Kristoffersen EK, Bolann BJ. Environmental pollutants in blood donors: The multicentre Norwegian donor study. Transfusion Medicine. 2020:1-9 FRIDAID 1796445 doi:10.1111/tme.12662 1365-3148 https://hdl.handle.net/10037/20854 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1111/tme.12662 2021-06-25T17:57:58Z Objectives - The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background - Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants. Methods/Materials - Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP‐MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh‐pressure liquid chromatography coupled with a triple‐quadrupole mass spectrometer (UHPLC‐MS/MS). Results - Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09 μmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16 nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91 ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age. Conclusion - A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants. Article in Journal/Newspaper Kirkenes Tromsø University of Tromsø: Munin Open Research Archive Bergen Tromsø Transfusion Medicine 30 3 201 209 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
spellingShingle |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar Klæboe Bolann, Bjørn Johan Environmental pollutants in blood donors: The multicentre Norwegian donor study |
topic_facet |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
description |
Objectives - The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background - Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants. Methods/Materials - Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP‐MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh‐pressure liquid chromatography coupled with a triple‐quadrupole mass spectrometer (UHPLC‐MS/MS). Results - Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09 μmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16 nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91 ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age. Conclusion - A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants. |
format |
Article in Journal/Newspaper |
author |
Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar Klæboe Bolann, Bjørn Johan |
author_facet |
Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar Klæboe Bolann, Bjørn Johan |
author_sort |
Averina, Maria |
title |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_short |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_full |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_fullStr |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_full_unstemmed |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_sort |
environmental pollutants in blood donors: the multicentre norwegian donor study |
publisher |
Wiley |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20854 https://doi.org/10.1111/tme.12662 |
geographic |
Bergen Tromsø |
geographic_facet |
Bergen Tromsø |
genre |
Kirkenes Tromsø |
genre_facet |
Kirkenes Tromsø |
op_relation |
Transfusion Medicine Averina M, Hervig T, Huber SH, Kjær MK, Kristoffersen EK, Bolann BJ. Environmental pollutants in blood donors: The multicentre Norwegian donor study. Transfusion Medicine. 2020:1-9 FRIDAID 1796445 doi:10.1111/tme.12662 1365-3148 https://hdl.handle.net/10037/20854 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1111/tme.12662 |
container_title |
Transfusion Medicine |
container_volume |
30 |
container_issue |
3 |
container_start_page |
201 |
op_container_end_page |
209 |
_version_ |
1766057988966055936 |