Can bone mineral density loss in the non-weight bearing distal forearm predict mortality?
Purpose - Low bone mineral density (BMD) is associated with increased risk of fractures and mortality. We investigated if rate of BMD loss in the distal forearm over seven years predicted mortality. Methods - 1725 postmenopausal women and 1879 men aged 50–74 who participated in the longitudinal Trom...
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Online Access: | https://hdl.handle.net/10037/20692 https://doi.org/10.1016/j.bone.2020.115347 |
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ftunivtroemsoe:oai:munin.uit.no:10037/20692 2023-05-15T18:34:46+02:00 Can bone mineral density loss in the non-weight bearing distal forearm predict mortality? Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Emaus, Nina Strand, Bjørn Heine 2020-03-30 https://hdl.handle.net/10037/20692 https://doi.org/10.1016/j.bone.2020.115347 eng eng Elsevier Bone Hauger AV, Bergland A, Holvik K, Emaus N, Strand BH. Can bone mineral density loss in the non-weight bearing distal forearm predict mortality?. Bone. 2020;136 FRIDAID 1805564 doi:10.1016/j.bone.2020.115347 8756-3282 1873-2763 https://hdl.handle.net/10037/20692 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Health sciences: 800 VDP::Medisinske Fag: 700::Helsefag: 800 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1016/j.bone.2020.115347 2021-06-25T17:57:56Z Purpose - Low bone mineral density (BMD) is associated with increased risk of fractures and mortality. We investigated if rate of BMD loss in the distal forearm over seven years predicted mortality. Methods - 1725 postmenopausal women and 1879 men aged 50–74 who participated in the longitudinal Tromsø Study waves 4 (1994–95) and 5 (2001−2002) were included. Cox regression models adjusted for lifestyle- and health related variables were used to assess associations between BMD change over seven years and subsequent mortality during up to 17 years of follow-up in participants with normal and low BMD at baseline. Results - Baseline BMD decreased and seven-year bone loss increased with increasing age. Overall, mortality rates were higher among those with low versus normal BMD (38 vs 19 per 1000 py in women, 56 vs 34 in men) and at higher bone loss rates (rate ratio high:low = 1.2 in women, 1.7 in men). BMD change was associated with increased mortality only in men with normal baseline BMD. In this group, men with a BMD loss of >4% had significantly higher mortality (HR 1.50, 95% CI 1.21, 1.87) than men with increased or unchanged BMD. BMD change was not significantly associated with increased mortality in women or in men with low BMD at baseline. Conclusions - BMD loss in the distal forearm was associated with increased mortality in men with normal BMD at baseline, but not in women. We found no clear association between BMD loss and mortality in those with low BMD at baseline. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Bone 136 115347 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800 VDP::Medisinske Fag: 700::Helsefag: 800 |
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VDP::Medical disciplines: 700::Health sciences: 800 VDP::Medisinske Fag: 700::Helsefag: 800 Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Emaus, Nina Strand, Bjørn Heine Can bone mineral density loss in the non-weight bearing distal forearm predict mortality? |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800 VDP::Medisinske Fag: 700::Helsefag: 800 |
description |
Purpose - Low bone mineral density (BMD) is associated with increased risk of fractures and mortality. We investigated if rate of BMD loss in the distal forearm over seven years predicted mortality. Methods - 1725 postmenopausal women and 1879 men aged 50–74 who participated in the longitudinal Tromsø Study waves 4 (1994–95) and 5 (2001−2002) were included. Cox regression models adjusted for lifestyle- and health related variables were used to assess associations between BMD change over seven years and subsequent mortality during up to 17 years of follow-up in participants with normal and low BMD at baseline. Results - Baseline BMD decreased and seven-year bone loss increased with increasing age. Overall, mortality rates were higher among those with low versus normal BMD (38 vs 19 per 1000 py in women, 56 vs 34 in men) and at higher bone loss rates (rate ratio high:low = 1.2 in women, 1.7 in men). BMD change was associated with increased mortality only in men with normal baseline BMD. In this group, men with a BMD loss of >4% had significantly higher mortality (HR 1.50, 95% CI 1.21, 1.87) than men with increased or unchanged BMD. BMD change was not significantly associated with increased mortality in women or in men with low BMD at baseline. Conclusions - BMD loss in the distal forearm was associated with increased mortality in men with normal BMD at baseline, but not in women. We found no clear association between BMD loss and mortality in those with low BMD at baseline. |
format |
Article in Journal/Newspaper |
author |
Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Emaus, Nina Strand, Bjørn Heine |
author_facet |
Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Emaus, Nina Strand, Bjørn Heine |
author_sort |
Hauger, Annette Vogt |
title |
Can bone mineral density loss in the non-weight bearing distal forearm predict mortality? |
title_short |
Can bone mineral density loss in the non-weight bearing distal forearm predict mortality? |
title_full |
Can bone mineral density loss in the non-weight bearing distal forearm predict mortality? |
title_fullStr |
Can bone mineral density loss in the non-weight bearing distal forearm predict mortality? |
title_full_unstemmed |
Can bone mineral density loss in the non-weight bearing distal forearm predict mortality? |
title_sort |
can bone mineral density loss in the non-weight bearing distal forearm predict mortality? |
publisher |
Elsevier |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20692 https://doi.org/10.1016/j.bone.2020.115347 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Bone Hauger AV, Bergland A, Holvik K, Emaus N, Strand BH. Can bone mineral density loss in the non-weight bearing distal forearm predict mortality?. Bone. 2020;136 FRIDAID 1805564 doi:10.1016/j.bone.2020.115347 8756-3282 1873-2763 https://hdl.handle.net/10037/20692 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1016/j.bone.2020.115347 |
container_title |
Bone |
container_volume |
136 |
container_start_page |
115347 |
_version_ |
1766219673826754560 |