Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection
B cell responses are a crucial part of the adaptive immune response to viral infection. Infection by salmonid alphavirus subtype 3 (SAV3) causes pancreas disease (PD) in Atlantic salmon ( Salmo salar ) and is a serious concern to the aquaculture industry. In this study, we have used intraperitoneal...
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Online Access: | https://hdl.handle.net/10037/20668 https://doi.org/10.3389/fimmu.2020.01682 |
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ftunivtroemsoe:oai:munin.uit.no:10037/20668 2023-05-15T15:29:56+02:00 Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection Jenberie, Shiferaw Penaranda, Ma Michelle Demogina Thim, Hanna Leena Styrvold, Morten Bay Strandskog, Guro Jørgensen, Jorunn B Jensen, Ingvill 2020-09-10 https://hdl.handle.net/10037/20668 https://doi.org/10.3389/fimmu.2020.01682 eng eng Frontiers Media Frontiers in Immunology info:eu-repo/grantAgreement/RCN/HAVBRUK2/280847/Norway/Comparing the protection of attenuated and inactivated virus vaccines against pancreas disease and heart and skeletal muscle inflammation// info:eu-repo/grantAgreement/RCN/HAVBRUK2/254892/Norway/Multiple routes to B cell memory in Atlantic salmon// Jenberie S, Penaranda MMD, Thim HL, Styrvold, Strandskog G, Jørgensen JB, Jensen I. Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection. Frontiers in Immunology. 2020;11 FRIDAID 1894014 doi:10.3389/fimmu.2020.01682 1664-3224 https://hdl.handle.net/10037/20668 openAccess Copyright 2020 The Author(s) VDP::Agriculture and fishery disciplines: 900::Fisheries science: 920 VDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.3389/fimmu.2020.01682 2021-06-25T17:58:05Z B cell responses are a crucial part of the adaptive immune response to viral infection. Infection by salmonid alphavirus subtype 3 (SAV3) causes pancreas disease (PD) in Atlantic salmon ( Salmo salar ) and is a serious concern to the aquaculture industry. In this study, we have used intraperitoneal (IP) infection with SAV3 as a model to characterize local B cell responses in the peritoneal cavity (PerC) and systemic immune tissues (head kidney/spleen). Intraperitoneal administration of vaccines is common in Atlantic salmon and understanding more about the local PerC B cell response is fundamental. Intraperitoneal SAV3 infection clearly induced PerC B cell responses as assessed by increased frequency of IgM + B cells and total IgM secreting cells (ASC). These PerC responses were prolonged up to nine weeks post-infection and positively correlated to the anti-SAV3 E2 and to neutralizing antibody responses in serum. For the systemic immune sites, virus-induced changes in B cell responses were more modest or decreased compared to controls in the same period. Collectively, data reported herein indicated that PerC could serve as a peripheral immunological site by providing a niche for prolonged maintenance of the ASC response in Atlantic salmon. Article in Journal/Newspaper Atlantic salmon Salmo salar University of Tromsø: Munin Open Research Archive Frontiers in Immunology 11 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Agriculture and fishery disciplines: 900::Fisheries science: 920 VDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920 |
spellingShingle |
VDP::Agriculture and fishery disciplines: 900::Fisheries science: 920 VDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920 Jenberie, Shiferaw Penaranda, Ma Michelle Demogina Thim, Hanna Leena Styrvold, Morten Bay Strandskog, Guro Jørgensen, Jorunn B Jensen, Ingvill Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection |
topic_facet |
VDP::Agriculture and fishery disciplines: 900::Fisheries science: 920 VDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920 |
description |
B cell responses are a crucial part of the adaptive immune response to viral infection. Infection by salmonid alphavirus subtype 3 (SAV3) causes pancreas disease (PD) in Atlantic salmon ( Salmo salar ) and is a serious concern to the aquaculture industry. In this study, we have used intraperitoneal (IP) infection with SAV3 as a model to characterize local B cell responses in the peritoneal cavity (PerC) and systemic immune tissues (head kidney/spleen). Intraperitoneal administration of vaccines is common in Atlantic salmon and understanding more about the local PerC B cell response is fundamental. Intraperitoneal SAV3 infection clearly induced PerC B cell responses as assessed by increased frequency of IgM + B cells and total IgM secreting cells (ASC). These PerC responses were prolonged up to nine weeks post-infection and positively correlated to the anti-SAV3 E2 and to neutralizing antibody responses in serum. For the systemic immune sites, virus-induced changes in B cell responses were more modest or decreased compared to controls in the same period. Collectively, data reported herein indicated that PerC could serve as a peripheral immunological site by providing a niche for prolonged maintenance of the ASC response in Atlantic salmon. |
format |
Article in Journal/Newspaper |
author |
Jenberie, Shiferaw Penaranda, Ma Michelle Demogina Thim, Hanna Leena Styrvold, Morten Bay Strandskog, Guro Jørgensen, Jorunn B Jensen, Ingvill |
author_facet |
Jenberie, Shiferaw Penaranda, Ma Michelle Demogina Thim, Hanna Leena Styrvold, Morten Bay Strandskog, Guro Jørgensen, Jorunn B Jensen, Ingvill |
author_sort |
Jenberie, Shiferaw |
title |
Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection |
title_short |
Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection |
title_full |
Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection |
title_fullStr |
Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection |
title_full_unstemmed |
Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection |
title_sort |
salmonid alphavirus subtype 3 induces prolonged local b cell responses in atlantic salmon (salmo salar) after intraperitoneal infection |
publisher |
Frontiers Media |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20668 https://doi.org/10.3389/fimmu.2020.01682 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
Frontiers in Immunology info:eu-repo/grantAgreement/RCN/HAVBRUK2/280847/Norway/Comparing the protection of attenuated and inactivated virus vaccines against pancreas disease and heart and skeletal muscle inflammation// info:eu-repo/grantAgreement/RCN/HAVBRUK2/254892/Norway/Multiple routes to B cell memory in Atlantic salmon// Jenberie S, Penaranda MMD, Thim HL, Styrvold, Strandskog G, Jørgensen JB, Jensen I. Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection. Frontiers in Immunology. 2020;11 FRIDAID 1894014 doi:10.3389/fimmu.2020.01682 1664-3224 https://hdl.handle.net/10037/20668 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.3389/fimmu.2020.01682 |
container_title |
Frontiers in Immunology |
container_volume |
11 |
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1766360393699033088 |