Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage
Background - Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial...
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ftunivtroemsoe:oai:munin.uit.no:10037/20614 2023-05-15T18:34:18+02:00 Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage Iakunchykova, Olena Averina, Maria Wilsgaard, Tom Watkins, Hugh Malyutina, Sofia Ragino, Yulia Keogh, Ruth Kudryavtsev, Alexander V Govorun, Vadim Cook, Sarah Anne Schirmer, Henrik Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David Adrew 2020-05-15 https://hdl.handle.net/10037/20614 https://doi.org/10.1136/jech-2020-213885 eng eng BMJ Iakunchykova, O. (2021). A biomarker approach to explain high cardiovascular disease burden in Russia: insights from population-based studies in Russia and Norway. (Doctoral thesis). https://hdl.handle.net/10037/20633 . Journal of Epidemiology and Community Health info:eu-repo/grantAgreement/RCN/BEDREHELSE/289440/Norway/Healthy choices and the social gradient// Iakunchykova O, Averina M, Wilsgaard T, Watkins H, Malyutina S, Ragino, Keogh R, Kudryavtsev AV, Govorun, Cook SA, Schirmer H, Eggen AE, Hopstock LA, Leon DA. Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage. . Journal of Epidemiology and Community Health. 2020 FRIDAID 1820078 doi:10.1136/jech-2020-213885 0143-005X 1470-2738 https://hdl.handle.net/10037/20614 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1136/jech-2020-213885 2021-06-25T17:58:03Z Background - Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk. Methods - We compared age-standardised mean levels of CVD biomarkers for men and women aged 40–69 years measured in two cross-sectional population-based studies: Know Your Heart (KYH) (Russia, 2015–2018; n=4046) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2018; n=17 646). A laboratory calibration study was performed to account for inter-laboratory differences. Results - Levels of total, low-density lipoprotein-, high-density lipoprotein-cholesterol and triglycerides were comparable in KYH and Tromsø 7 studies. N-terminal pro-b-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT) and high-sensitivity C-reactive protein (hsCRP) were higher in KYH compared with Tromsø 7 (NT-proBNP was higher by 54.1% (95% CI 41.5% to 67.8%) in men and by 30.8% (95% CI 22.9% to 39.2%) in women; hs-cTnT—by 42.4% (95% CI 36.1% to 49.0%) in men and by 68.1% (95% CI 62.4% to 73.9%) in women; hsCRP—by 33.3% (95% CI 26.1% to 40.8%) in men and by 35.6% (95% CI 29.0% to 42.6%) in women). Exclusion of participants with pre-existing coronary heart disease (279 men and 282 women) had no substantive effect. Conclusions - Differences in cholesterol fractions cannot explain the difference in CVD mortality rate between Russia and Norway. A non-ischemic pathway to the cardiac damage reflected by raised NT-proBNP and hs-cTnT is likely to contribute to high CVD mortality in Russia. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø Journal of Epidemiology and Community Health jech-2020-213885 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Iakunchykova, Olena Averina, Maria Wilsgaard, Tom Watkins, Hugh Malyutina, Sofia Ragino, Yulia Keogh, Ruth Kudryavtsev, Alexander V Govorun, Vadim Cook, Sarah Anne Schirmer, Henrik Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David Adrew Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 |
description |
Background - Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk. Methods - We compared age-standardised mean levels of CVD biomarkers for men and women aged 40–69 years measured in two cross-sectional population-based studies: Know Your Heart (KYH) (Russia, 2015–2018; n=4046) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2018; n=17 646). A laboratory calibration study was performed to account for inter-laboratory differences. Results - Levels of total, low-density lipoprotein-, high-density lipoprotein-cholesterol and triglycerides were comparable in KYH and Tromsø 7 studies. N-terminal pro-b-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT) and high-sensitivity C-reactive protein (hsCRP) were higher in KYH compared with Tromsø 7 (NT-proBNP was higher by 54.1% (95% CI 41.5% to 67.8%) in men and by 30.8% (95% CI 22.9% to 39.2%) in women; hs-cTnT—by 42.4% (95% CI 36.1% to 49.0%) in men and by 68.1% (95% CI 62.4% to 73.9%) in women; hsCRP—by 33.3% (95% CI 26.1% to 40.8%) in men and by 35.6% (95% CI 29.0% to 42.6%) in women). Exclusion of participants with pre-existing coronary heart disease (279 men and 282 women) had no substantive effect. Conclusions - Differences in cholesterol fractions cannot explain the difference in CVD mortality rate between Russia and Norway. A non-ischemic pathway to the cardiac damage reflected by raised NT-proBNP and hs-cTnT is likely to contribute to high CVD mortality in Russia. |
format |
Article in Journal/Newspaper |
author |
Iakunchykova, Olena Averina, Maria Wilsgaard, Tom Watkins, Hugh Malyutina, Sofia Ragino, Yulia Keogh, Ruth Kudryavtsev, Alexander V Govorun, Vadim Cook, Sarah Anne Schirmer, Henrik Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David Adrew |
author_facet |
Iakunchykova, Olena Averina, Maria Wilsgaard, Tom Watkins, Hugh Malyutina, Sofia Ragino, Yulia Keogh, Ruth Kudryavtsev, Alexander V Govorun, Vadim Cook, Sarah Anne Schirmer, Henrik Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David Adrew |
author_sort |
Iakunchykova, Olena |
title |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_short |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_full |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_fullStr |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_full_unstemmed |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_sort |
why does russia have such high cardiovascular mortality rates? comparisons of blood-based biomarkers with norway implicate non-ischaemic cardiac damage |
publisher |
BMJ |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20614 https://doi.org/10.1136/jech-2020-213885 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Iakunchykova, O. (2021). A biomarker approach to explain high cardiovascular disease burden in Russia: insights from population-based studies in Russia and Norway. (Doctoral thesis). https://hdl.handle.net/10037/20633 . Journal of Epidemiology and Community Health info:eu-repo/grantAgreement/RCN/BEDREHELSE/289440/Norway/Healthy choices and the social gradient// Iakunchykova O, Averina M, Wilsgaard T, Watkins H, Malyutina S, Ragino, Keogh R, Kudryavtsev AV, Govorun, Cook SA, Schirmer H, Eggen AE, Hopstock LA, Leon DA. Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage. . Journal of Epidemiology and Community Health. 2020 FRIDAID 1820078 doi:10.1136/jech-2020-213885 0143-005X 1470-2738 https://hdl.handle.net/10037/20614 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1136/jech-2020-213885 |
container_title |
Journal of Epidemiology and Community Health |
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jech-2020-213885 |
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1766218998602530816 |