An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study
Objective - The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants...
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Online Access: | https://hdl.handle.net/10037/20500 https://doi.org/10.1016/j.jns.2020.117268 |
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ftunivtroemsoe:oai:munin.uit.no:10037/20500 2023-05-15T18:34:27+02:00 An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study Hindenes, Lars Bakke Håberg, Asta Kristine Mathiesen, Ellisiv B Vangberg, Torgil Riise 2020-12-11 https://hdl.handle.net/10037/20500 https://doi.org/10.1016/j.jns.2020.117268 eng eng Elsevier Hindenes, L.B. (2021). Circle of Willis variants and cerebrovascular health: Representations, prevalences, functions and related consequences. Incomplete anatomy and changes to flow appear to induce more unfavourable health outcomes. (Doctoral thesis). https://hdl.handle.net/10037/22958 . Journal of Neurological Sciences Hindenes, Håberg, Mathiesen, Vangberg. An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study. Journal of Neurological Sciences. 2020;420(117268) FRIDAID 1861208 doi:10.1016/j.jns.2020.117268 1302-1664 https://hdl.handle.net/10037/20500 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752 The Tromsø Study Tromsøundersøkelsen Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1016/j.jns.2020.117268 2021-11-10T23:54:29Z Objective - The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. Methods - In a cross-sectional population sample of 1751 people (age 40–84 years, 46.4% men), we used an automated method to segment WMH using T1-weighted and T2-weighted fluid-attenuated inversion recovery image obtained at 3T. CoW variants were classified from time-of-flight scans, also at 3T. WMH risk factors, including age, sex, smoking and blood pressure, were obtained from questionnaires and clinical examinations. We used linear regression to examine whether people with incomplete CoW variants had greater volumes of deep WMH (DWMH) and periventricular WMH (PWMH) compared to people with the complete CoW, correcting for WMH risk factors. Results - Participants with incomplete CoW variants did not have significantly higher DWMH or PWMH volumes than those with complete CoW when accounting for risk factors. Age, pack-years smoking, and systolic blood pressure were risk factors for increased DWMH and PWMH volume. Diabetes was a unique risk factor for increased PWMH volume. Conclusion - Incomplete CoW variants do not appear to be risk factors for WMH in the general population. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Willis ENVELOPE(159.450,159.450,-79.367,-79.367) Journal of the Neurological Sciences 420 117268 |
institution |
Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752 The Tromsø Study Tromsøundersøkelsen |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752 The Tromsø Study Tromsøundersøkelsen Hindenes, Lars Bakke Håberg, Asta Kristine Mathiesen, Ellisiv B Vangberg, Torgil Riise An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752 The Tromsø Study Tromsøundersøkelsen |
description |
Objective - The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. Methods - In a cross-sectional population sample of 1751 people (age 40–84 years, 46.4% men), we used an automated method to segment WMH using T1-weighted and T2-weighted fluid-attenuated inversion recovery image obtained at 3T. CoW variants were classified from time-of-flight scans, also at 3T. WMH risk factors, including age, sex, smoking and blood pressure, were obtained from questionnaires and clinical examinations. We used linear regression to examine whether people with incomplete CoW variants had greater volumes of deep WMH (DWMH) and periventricular WMH (PWMH) compared to people with the complete CoW, correcting for WMH risk factors. Results - Participants with incomplete CoW variants did not have significantly higher DWMH or PWMH volumes than those with complete CoW when accounting for risk factors. Age, pack-years smoking, and systolic blood pressure were risk factors for increased DWMH and PWMH volume. Diabetes was a unique risk factor for increased PWMH volume. Conclusion - Incomplete CoW variants do not appear to be risk factors for WMH in the general population. |
format |
Article in Journal/Newspaper |
author |
Hindenes, Lars Bakke Håberg, Asta Kristine Mathiesen, Ellisiv B Vangberg, Torgil Riise |
author_facet |
Hindenes, Lars Bakke Håberg, Asta Kristine Mathiesen, Ellisiv B Vangberg, Torgil Riise |
author_sort |
Hindenes, Lars Bakke |
title |
An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study |
title_short |
An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study |
title_full |
An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study |
title_fullStr |
An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study |
title_full_unstemmed |
An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study |
title_sort |
incomplete circle of willis is not a risk factor for white matter hyperintensities: the tromsø study |
publisher |
Elsevier |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20500 https://doi.org/10.1016/j.jns.2020.117268 |
long_lat |
ENVELOPE(159.450,159.450,-79.367,-79.367) |
geographic |
Tromsø Willis |
geographic_facet |
Tromsø Willis |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Hindenes, L.B. (2021). Circle of Willis variants and cerebrovascular health: Representations, prevalences, functions and related consequences. Incomplete anatomy and changes to flow appear to induce more unfavourable health outcomes. (Doctoral thesis). https://hdl.handle.net/10037/22958 . Journal of Neurological Sciences Hindenes, Håberg, Mathiesen, Vangberg. An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study. Journal of Neurological Sciences. 2020;420(117268) FRIDAID 1861208 doi:10.1016/j.jns.2020.117268 1302-1664 https://hdl.handle.net/10037/20500 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1016/j.jns.2020.117268 |
container_title |
Journal of the Neurological Sciences |
container_volume |
420 |
container_start_page |
117268 |
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1766219187933413376 |