Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study
Introduction - Red cell distribution width (RDW) is associated with cardiovascular diseases, including atrial fibrillation (AF) and venous thromboembolism (VTE). Whether RDW is a risk marker for thromboembolic events in AF patients is scarcely known. We aimed to assess the association between RDW an...
Published in: | TH Open |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Thieme Publishing
2020
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/20420 https://doi.org/10.1055/s-0040-1716417 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/20420 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/20420 2023-05-15T18:34:28+02:00 Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study Hald, Erin Mathiesen Løchen, Maja-Lisa Lappegård, Jostein Ellingsen, Trygve Mathiesen, Ellisiv B. Wilsgaard, Tom Njølstad, Inger Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2020-09-28 https://hdl.handle.net/10037/20420 https://doi.org/10.1055/s-0040-1716417 eng eng Thieme Publishing TH Open Hald EM, Løchen M, Lappegård J, Ellingsen T, Mathiesen EB, Wilsgaard T, Njølstad i, Brækkan SK, Hansen JB. Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study. TH Open. 2020;4(3):e280-e287 FRIDAID 1875480 doi:10.1055/s-0040-1716417 2512-9465 https://hdl.handle.net/10037/20420 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1055/s-0040-1716417 2021-06-25T17:58:00Z Introduction - Red cell distribution width (RDW) is associated with cardiovascular diseases, including atrial fibrillation (AF) and venous thromboembolism (VTE). Whether RDW is a risk marker for thromboembolic events in AF patients is scarcely known. We aimed to assess the association between RDW and the risk of AF, and AF-related VTE and ischemic stroke, in a population-based cohort. Methods - We measured RDW in 26,111 participants from the Tromsø Study (1994–1995), and registered incident AF cases through December 31, 2013. Among participants with AF, first-ever VTEs and ischemic strokes were registered from the date of AF diagnosis through the end of follow-up. We calculated hazard ratios (HRs) with 95% confidence intervals (CIs) for AF by quartiles of RDW. Furthermore, we calculated cause-specific HRs for VTE and ischemic stroke by tertiles of RDW for participants with AF. Results - There were 2,081 incident AF cases during a median of 18.8 years of follow-up. Subjects with RDW in the highest quartile (RDW ≥ 13.3%) had 30% higher risk of AF than those in the lowest quartile (RDW ≤ 12.3%). Among those with AF, subjects with RDW in the upper tertile had a doubled risk of ischemic stroke (HR 2.07, 95% CI 1.20–3.57). In contrast, RDW was not associated with incident VTE in subjects with AF. Conclusion - RDW was significantly associated with incident AF in a general population. Among subjects with AF, high RDW was associated with ischemic stroke, but not VTE. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø TH Open 04 03 e280 e287 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 |
spellingShingle |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 Hald, Erin Mathiesen Løchen, Maja-Lisa Lappegård, Jostein Ellingsen, Trygve Mathiesen, Ellisiv B. Wilsgaard, Tom Njølstad, Inger Brækkan, Sigrid Kufaas Hansen, John-Bjarne Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 |
description |
Introduction - Red cell distribution width (RDW) is associated with cardiovascular diseases, including atrial fibrillation (AF) and venous thromboembolism (VTE). Whether RDW is a risk marker for thromboembolic events in AF patients is scarcely known. We aimed to assess the association between RDW and the risk of AF, and AF-related VTE and ischemic stroke, in a population-based cohort. Methods - We measured RDW in 26,111 participants from the Tromsø Study (1994–1995), and registered incident AF cases through December 31, 2013. Among participants with AF, first-ever VTEs and ischemic strokes were registered from the date of AF diagnosis through the end of follow-up. We calculated hazard ratios (HRs) with 95% confidence intervals (CIs) for AF by quartiles of RDW. Furthermore, we calculated cause-specific HRs for VTE and ischemic stroke by tertiles of RDW for participants with AF. Results - There were 2,081 incident AF cases during a median of 18.8 years of follow-up. Subjects with RDW in the highest quartile (RDW ≥ 13.3%) had 30% higher risk of AF than those in the lowest quartile (RDW ≤ 12.3%). Among those with AF, subjects with RDW in the upper tertile had a doubled risk of ischemic stroke (HR 2.07, 95% CI 1.20–3.57). In contrast, RDW was not associated with incident VTE in subjects with AF. Conclusion - RDW was significantly associated with incident AF in a general population. Among subjects with AF, high RDW was associated with ischemic stroke, but not VTE. |
format |
Article in Journal/Newspaper |
author |
Hald, Erin Mathiesen Løchen, Maja-Lisa Lappegård, Jostein Ellingsen, Trygve Mathiesen, Ellisiv B. Wilsgaard, Tom Njølstad, Inger Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Hald, Erin Mathiesen Løchen, Maja-Lisa Lappegård, Jostein Ellingsen, Trygve Mathiesen, Ellisiv B. Wilsgaard, Tom Njølstad, Inger Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Hald, Erin Mathiesen |
title |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_short |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_full |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_fullStr |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_full_unstemmed |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_sort |
red cell distribution width and risk of atrial fibrillation and subsequent thromboembolism: the tromsø study |
publisher |
Thieme Publishing |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20420 https://doi.org/10.1055/s-0040-1716417 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
TH Open Hald EM, Løchen M, Lappegård J, Ellingsen T, Mathiesen EB, Wilsgaard T, Njølstad i, Brækkan SK, Hansen JB. Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study. TH Open. 2020;4(3):e280-e287 FRIDAID 1875480 doi:10.1055/s-0040-1716417 2512-9465 https://hdl.handle.net/10037/20420 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1055/s-0040-1716417 |
container_title |
TH Open |
container_volume |
04 |
container_issue |
03 |
container_start_page |
e280 |
op_container_end_page |
e287 |
_version_ |
1766219231074975744 |