Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study
The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of...
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ftunivtroemsoe:oai:munin.uit.no:10037/20374 2023-05-15T18:34:42+02:00 Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study Hindenes, Lars Bakke Håberg, Asta Johnsen, Liv-Hege Mathiesen, Ellisiv B. David, Robben Vangberg, Torgil Riise 2020-11-03 https://hdl.handle.net/10037/20374 https://doi.org/10.1371/journal.pone.0241373 eng eng Public Library of Science Hindenes, L.B. (2021). Circle of Willis variants and cerebrovascular health: Representations, prevalences, functions and related consequences. Incomplete anatomy and changes to flow appear to induce more unfavourable health outcomes. (Doctoral thesis). https://hdl.handle.net/10037/22958 . PLOS ONE Helse Nord RHF: SFP1271- 16 Helse Nord RHF: HNF1369-17 Hindenes LB, Håberg A, Johnsen LH, Mathiesen EB, David, Vangberg TR. Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study. PLOS ONE. 2020 FRIDAID 1860179 doi:10.1371/journal.pone.0241373 1932-6203 https://hdl.handle.net/10037/20374 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1371/journal.pone.0241373 2021-11-10T23:54:29Z The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40–87 years), and independent and conditional frequencies of the CoW’s artery segments. CoW segments were classified as present or missing/hypoplastic (w/1mm diameter threshold) on 3T time-of-flight magnetic resonance angiography images. We also examined whether age and sex were associated with CoW variants. We identified 47 unique CoW variants, of which five variants constituted 68.5% of the sample. The complete variant was found in 11.9% of the subjects, and the most common variant (27.8%) was missing both posterior communicating arteries. Conditional frequencies showed patterns of interdependence across most missing segments in the CoW. CoW variants were associated with mean-split age (P = .0147), and there was a trend showing more missing segments with increasing age. We found no association with sex (P = .0526). Our population study demonstrated age as associated with CoW variants, suggesting reduced collateral capacity with older age. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Willis ENVELOPE(159.450,159.450,-79.367,-79.367) PLOS ONE 15 11 e0241373 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 |
spellingShingle |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 Hindenes, Lars Bakke Håberg, Asta Johnsen, Liv-Hege Mathiesen, Ellisiv B. David, Robben Vangberg, Torgil Riise Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 |
description |
The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40–87 years), and independent and conditional frequencies of the CoW’s artery segments. CoW segments were classified as present or missing/hypoplastic (w/1mm diameter threshold) on 3T time-of-flight magnetic resonance angiography images. We also examined whether age and sex were associated with CoW variants. We identified 47 unique CoW variants, of which five variants constituted 68.5% of the sample. The complete variant was found in 11.9% of the subjects, and the most common variant (27.8%) was missing both posterior communicating arteries. Conditional frequencies showed patterns of interdependence across most missing segments in the CoW. CoW variants were associated with mean-split age (P = .0147), and there was a trend showing more missing segments with increasing age. We found no association with sex (P = .0526). Our population study demonstrated age as associated with CoW variants, suggesting reduced collateral capacity with older age. |
format |
Article in Journal/Newspaper |
author |
Hindenes, Lars Bakke Håberg, Asta Johnsen, Liv-Hege Mathiesen, Ellisiv B. David, Robben Vangberg, Torgil Riise |
author_facet |
Hindenes, Lars Bakke Håberg, Asta Johnsen, Liv-Hege Mathiesen, Ellisiv B. David, Robben Vangberg, Torgil Riise |
author_sort |
Hindenes, Lars Bakke |
title |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_short |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_full |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_fullStr |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_full_unstemmed |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_sort |
variations in the circle of willis in a large population sample using 3d tof angiography: the tromsø study |
publisher |
Public Library of Science |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20374 https://doi.org/10.1371/journal.pone.0241373 |
long_lat |
ENVELOPE(159.450,159.450,-79.367,-79.367) |
geographic |
Tromsø Willis |
geographic_facet |
Tromsø Willis |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Hindenes, L.B. (2021). Circle of Willis variants and cerebrovascular health: Representations, prevalences, functions and related consequences. Incomplete anatomy and changes to flow appear to induce more unfavourable health outcomes. (Doctoral thesis). https://hdl.handle.net/10037/22958 . PLOS ONE Helse Nord RHF: SFP1271- 16 Helse Nord RHF: HNF1369-17 Hindenes LB, Håberg A, Johnsen LH, Mathiesen EB, David, Vangberg TR. Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study. PLOS ONE. 2020 FRIDAID 1860179 doi:10.1371/journal.pone.0241373 1932-6203 https://hdl.handle.net/10037/20374 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1371/journal.pone.0241373 |
container_title |
PLOS ONE |
container_volume |
15 |
container_issue |
11 |
container_start_page |
e0241373 |
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