Diversified regulation of circadian clock gene expression following whole genome duplication
Across taxa, circadian control of physiology and behavior arises from cell-autonomous oscillations in gene expression, governed by a networks of so-called ‘clock genes’, collectively forming transcription-translation feedback loops. In modern vertebrates, these networks contain multiple copies of cl...
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Online Access: | https://hdl.handle.net/10037/20373 https://doi.org/10.1371/journal.pgen.1009097 |
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ftunivtroemsoe:oai:munin.uit.no:10037/20373 2023-05-15T15:32:42+02:00 Diversified regulation of circadian clock gene expression following whole genome duplication West, Alexander Christopher Iversen, Marianne Jørgensen, Even Hjalmar Sandve, Simen Rød Hazlerigg, David Wood, Shona Hiedi 2020-10-08 https://hdl.handle.net/10037/20373 https://doi.org/10.1371/journal.pgen.1009097 eng eng Public Library of Science Iversen, M. (2021). Photoperiodic history-dependent preadaptation of the smolting gill. Novel players and SW immediate response as markers of growth and welfare. (Doctoral thesis). https://hdl.handle.net/10037/20678 PLoS Genetics info:eu-repo/grantAgreement/RCN/FRIMEDBIO/274669/Norway/The role of whole genome duplication in vertebrate adaptation// info:eu-repo/grantAgreement/RCN/FRIMEDBIO/241016/Norway/Light & Salt - Thyroid hormone deiodinase paralogues & the evolution of complex life-history strategy in salmonids.// West AC, Iversen M, Jørgensen E H, Sandve SR, Hazlerigg D, Wood SH. Diversified regulation of circadian clock gene expression following whole genome duplication. PLoS Genetics. 2020 FRIDAID 1831178 doi:10.1371/journal.pgen.1009097 1553-7390 1553-7404 https://hdl.handle.net/10037/20373 openAccess Copyright 2020 The Author(s) VDP::Mathematics and natural science: 400::Zoology and botany: 480 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1371/journal.pgen.1009097 2021-06-25T17:57:55Z Across taxa, circadian control of physiology and behavior arises from cell-autonomous oscillations in gene expression, governed by a networks of so-called ‘clock genes’, collectively forming transcription-translation feedback loops. In modern vertebrates, these networks contain multiple copies of clock gene family members, which arose through whole genome duplication (WGD) events during evolutionary history. It remains unclear to what extent multiple copies of clock gene family members are functionally redundant or have allowed for functional diversification. We addressed this problem through an analysis of clock gene expression in the Atlantic salmon, a representative of the salmonids, a group which has undergone at least 4 rounds of WGD since the base of the vertebrate lineage, giving an unusually large complement of clock genes. By comparing expression patterns across multiple tissues, and during development, we present evidence for gene- and tissue-specific divergence in expression patterns, consistent with functional diversification of clock gene duplicates. In contrast to mammals, we found no evidence for coupling between cortisol and circadian gene expression, but cortisol mediated non-circadian regulated expression of a subset of clock genes in the salmon gill was evident. This regulation is linked to changes in gill function necessary for the transition from fresh- to sea-water in anadromous fish. Overall, this analysis emphasises the potential for a richly diversified clock gene network to serve a mixture of circadian and non-circadian functions in vertebrate groups with complex genomes. Article in Journal/Newspaper Atlantic salmon University of Tromsø: Munin Open Research Archive PLOS Genetics 16 10 e1009097 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Mathematics and natural science: 400::Zoology and botany: 480 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480 |
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VDP::Mathematics and natural science: 400::Zoology and botany: 480 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480 West, Alexander Christopher Iversen, Marianne Jørgensen, Even Hjalmar Sandve, Simen Rød Hazlerigg, David Wood, Shona Hiedi Diversified regulation of circadian clock gene expression following whole genome duplication |
topic_facet |
VDP::Mathematics and natural science: 400::Zoology and botany: 480 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480 |
description |
Across taxa, circadian control of physiology and behavior arises from cell-autonomous oscillations in gene expression, governed by a networks of so-called ‘clock genes’, collectively forming transcription-translation feedback loops. In modern vertebrates, these networks contain multiple copies of clock gene family members, which arose through whole genome duplication (WGD) events during evolutionary history. It remains unclear to what extent multiple copies of clock gene family members are functionally redundant or have allowed for functional diversification. We addressed this problem through an analysis of clock gene expression in the Atlantic salmon, a representative of the salmonids, a group which has undergone at least 4 rounds of WGD since the base of the vertebrate lineage, giving an unusually large complement of clock genes. By comparing expression patterns across multiple tissues, and during development, we present evidence for gene- and tissue-specific divergence in expression patterns, consistent with functional diversification of clock gene duplicates. In contrast to mammals, we found no evidence for coupling between cortisol and circadian gene expression, but cortisol mediated non-circadian regulated expression of a subset of clock genes in the salmon gill was evident. This regulation is linked to changes in gill function necessary for the transition from fresh- to sea-water in anadromous fish. Overall, this analysis emphasises the potential for a richly diversified clock gene network to serve a mixture of circadian and non-circadian functions in vertebrate groups with complex genomes. |
format |
Article in Journal/Newspaper |
author |
West, Alexander Christopher Iversen, Marianne Jørgensen, Even Hjalmar Sandve, Simen Rød Hazlerigg, David Wood, Shona Hiedi |
author_facet |
West, Alexander Christopher Iversen, Marianne Jørgensen, Even Hjalmar Sandve, Simen Rød Hazlerigg, David Wood, Shona Hiedi |
author_sort |
West, Alexander Christopher |
title |
Diversified regulation of circadian clock gene expression following whole genome duplication |
title_short |
Diversified regulation of circadian clock gene expression following whole genome duplication |
title_full |
Diversified regulation of circadian clock gene expression following whole genome duplication |
title_fullStr |
Diversified regulation of circadian clock gene expression following whole genome duplication |
title_full_unstemmed |
Diversified regulation of circadian clock gene expression following whole genome duplication |
title_sort |
diversified regulation of circadian clock gene expression following whole genome duplication |
publisher |
Public Library of Science |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20373 https://doi.org/10.1371/journal.pgen.1009097 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
Iversen, M. (2021). Photoperiodic history-dependent preadaptation of the smolting gill. Novel players and SW immediate response as markers of growth and welfare. (Doctoral thesis). https://hdl.handle.net/10037/20678 PLoS Genetics info:eu-repo/grantAgreement/RCN/FRIMEDBIO/274669/Norway/The role of whole genome duplication in vertebrate adaptation// info:eu-repo/grantAgreement/RCN/FRIMEDBIO/241016/Norway/Light & Salt - Thyroid hormone deiodinase paralogues & the evolution of complex life-history strategy in salmonids.// West AC, Iversen M, Jørgensen E H, Sandve SR, Hazlerigg D, Wood SH. Diversified regulation of circadian clock gene expression following whole genome duplication. PLoS Genetics. 2020 FRIDAID 1831178 doi:10.1371/journal.pgen.1009097 1553-7390 1553-7404 https://hdl.handle.net/10037/20373 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1371/journal.pgen.1009097 |
container_title |
PLOS Genetics |
container_volume |
16 |
container_issue |
10 |
container_start_page |
e1009097 |
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1766363196817408000 |