Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study
Background - There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined. Method - In the seventh survey of the Tromsø...
Published in: | BMC Nutrition |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2020
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/20355 https://doi.org/10.1186/s40795-020-00381-4 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/20355 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/20355 2023-05-15T18:34:44+02:00 Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study Jorde, Rolf Grimnes, Guri 2020-11-02 https://hdl.handle.net/10037/20355 https://doi.org/10.1186/s40795-020-00381-4 eng eng BMC BMC Nutrition Jorde, Grimnes. Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study. BMC Nutrition. 2020;6(1) FRIDAID 1848931 doi:10.1186/s40795-020-00381-4 2055-0928 https://hdl.handle.net/10037/20355 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1186/s40795-020-00381-4 2021-06-25T17:57:55Z Background - There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined. Method - In the seventh survey of the Tromsø study, serum 25(OH)D and parathyroid hormone were measured, and questionnaires on calcium and vitamin D intakes filled in. Results - There were significant interactions between sex, calcium and vitamin D intakes regarding serum 25(OH)D level. The analyses were therefore done stratified. In males there was, regardless of vitamin D intake, a significant decrease in serum 25(OH)D with increasing calcium intake. The difference in serum 25(OH)D between those with the highest and lowest calcium intakes was approximately 10%. In the females, there was in subjects with low vitamin D intake (< 7 μg/d) a significant increase in serum 25(OH)D with increasing calcium intake, which could not be explained by secondary hyperparathyroidism. In females with higher vitamin D intakes, increasing calcium intake was associated with lower serum 25(OH)D levels. Conclusions - There is, at least in subjects with an adequate vitamin D intake, a negative association between calcium intake and serum 25(OH)D. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø BMC Nutrition 6 1 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 |
spellingShingle |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 Jorde, Rolf Grimnes, Guri Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
topic_facet |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 |
description |
Background - There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined. Method - In the seventh survey of the Tromsø study, serum 25(OH)D and parathyroid hormone were measured, and questionnaires on calcium and vitamin D intakes filled in. Results - There were significant interactions between sex, calcium and vitamin D intakes regarding serum 25(OH)D level. The analyses were therefore done stratified. In males there was, regardless of vitamin D intake, a significant decrease in serum 25(OH)D with increasing calcium intake. The difference in serum 25(OH)D between those with the highest and lowest calcium intakes was approximately 10%. In the females, there was in subjects with low vitamin D intake (< 7 μg/d) a significant increase in serum 25(OH)D with increasing calcium intake, which could not be explained by secondary hyperparathyroidism. In females with higher vitamin D intakes, increasing calcium intake was associated with lower serum 25(OH)D levels. Conclusions - There is, at least in subjects with an adequate vitamin D intake, a negative association between calcium intake and serum 25(OH)D. |
format |
Article in Journal/Newspaper |
author |
Jorde, Rolf Grimnes, Guri |
author_facet |
Jorde, Rolf Grimnes, Guri |
author_sort |
Jorde, Rolf |
title |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_short |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_full |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_fullStr |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_full_unstemmed |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_sort |
increased calcium intake is associated lower serum 25-hydroxyvitamin d levels in subjects with adequate vitamin d intake: a population-based observational study |
publisher |
BMC |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20355 https://doi.org/10.1186/s40795-020-00381-4 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMC Nutrition Jorde, Grimnes. Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study. BMC Nutrition. 2020;6(1) FRIDAID 1848931 doi:10.1186/s40795-020-00381-4 2055-0928 https://hdl.handle.net/10037/20355 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1186/s40795-020-00381-4 |
container_title |
BMC Nutrition |
container_volume |
6 |
container_issue |
1 |
_version_ |
1766219627357011968 |