Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study
Objectives - The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. Design and setting - A populations-based cohort study with repeated measurements, the Tromsø Study. P...
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ftunivtroemsoe:oai:munin.uit.no:10037/20184 2023-05-15T18:34:20+02:00 Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study Wilsgaard, Tom Vangen-Lønne, Anne Merete Mathiesen, Ellisiv B Løchen, Maja-Lisa Njølstad, Inger Heiss, Gerardo Danaei, Goodarz 2020-05-24 https://hdl.handle.net/10037/20184 https://doi.org/10.1136/bmjopen-2019-035584 eng eng BMJ Publishing Group BMJ Open Norges forskningsråd: 289440 Wilsgaard, Vangen-Lønne, Mathiesen, Løchen, Njølstad, Heiss, Danaei. Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study. BMJ Open. 2020 FRIDAID 1854998 doi:10.1136/bmjopen-2019-035584 2044-6055 https://hdl.handle.net/10037/20184 Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1136/bmjopen-2019-035584 2021-06-25T17:57:55Z Objectives - The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. Design and setting - A populations-based cohort study with repeated measurements, the Tromsø Study. Primary outcome measure - Myocardial infarction. Participants - We estimated the relative and absolute risk reduction under feasible and intensive risk reduction strategies for smoking, physical activity, alcohol drinking, body mass index, total serum cholesterol and systolic blood pressure in 14 965 men and women with 19 years of follow-up (1994–2013). Results - The estimated 19-year risk of MI under no intervention was 7.5% in individuals with baseline mean age 49.3 years (range 25–69). This risk was reduced by 30% (95% CI 19% to 39%) under joint feasible interventions on all risk factors, and 70% (60%, 78%) under a set of more intensive interventions. The most effective interventions were lowering of total cholesterol to 5.18 mmol/L and lowering of systolic blood pressure to 120 mm Hg (33% and 37% lower MI risk, respectively). The absolute risk reductions were significantly larger in men, in older participants, in smokers and in those with low education. Conclusion - Modification of population levels of cardiovascular risk factors could have prevented close to one-third of the cases of MI in the municipality of Tromsø during 19 years of follow-up. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø BMJ Open 10 5 e035584 |
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Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Wilsgaard, Tom Vangen-Lønne, Anne Merete Mathiesen, Ellisiv B Løchen, Maja-Lisa Njølstad, Inger Heiss, Gerardo Danaei, Goodarz Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
description |
Objectives - The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. Design and setting - A populations-based cohort study with repeated measurements, the Tromsø Study. Primary outcome measure - Myocardial infarction. Participants - We estimated the relative and absolute risk reduction under feasible and intensive risk reduction strategies for smoking, physical activity, alcohol drinking, body mass index, total serum cholesterol and systolic blood pressure in 14 965 men and women with 19 years of follow-up (1994–2013). Results - The estimated 19-year risk of MI under no intervention was 7.5% in individuals with baseline mean age 49.3 years (range 25–69). This risk was reduced by 30% (95% CI 19% to 39%) under joint feasible interventions on all risk factors, and 70% (60%, 78%) under a set of more intensive interventions. The most effective interventions were lowering of total cholesterol to 5.18 mmol/L and lowering of systolic blood pressure to 120 mm Hg (33% and 37% lower MI risk, respectively). The absolute risk reductions were significantly larger in men, in older participants, in smokers and in those with low education. Conclusion - Modification of population levels of cardiovascular risk factors could have prevented close to one-third of the cases of MI in the municipality of Tromsø during 19 years of follow-up. |
format |
Article in Journal/Newspaper |
author |
Wilsgaard, Tom Vangen-Lønne, Anne Merete Mathiesen, Ellisiv B Løchen, Maja-Lisa Njølstad, Inger Heiss, Gerardo Danaei, Goodarz |
author_facet |
Wilsgaard, Tom Vangen-Lønne, Anne Merete Mathiesen, Ellisiv B Løchen, Maja-Lisa Njølstad, Inger Heiss, Gerardo Danaei, Goodarz |
author_sort |
Wilsgaard, Tom |
title |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study |
title_short |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study |
title_full |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study |
title_fullStr |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study |
title_full_unstemmed |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study |
title_sort |
hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the tromsø study |
publisher |
BMJ Publishing Group |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/20184 https://doi.org/10.1136/bmjopen-2019-035584 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMJ Open Norges forskningsråd: 289440 Wilsgaard, Vangen-Lønne, Mathiesen, Løchen, Njølstad, Heiss, Danaei. Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study. BMJ Open. 2020 FRIDAID 1854998 doi:10.1136/bmjopen-2019-035584 2044-6055 https://hdl.handle.net/10037/20184 |
op_rights |
Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1136/bmjopen-2019-035584 |
container_title |
BMJ Open |
container_volume |
10 |
container_issue |
5 |
container_start_page |
e035584 |
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1766219032992677888 |