Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism
Venous thromboembolism is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of venous thromboembolism, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FG...
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UiT Norges arktiske universitet
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ftunivtroemsoe:oai:munin.uit.no:10037/19759 2023-05-15T18:34:46+02:00 Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism Paulsen, Benedikte 2019-10-31 https://hdl.handle.net/10037/19759 eng eng UiT Norges arktiske universitet UiT The Arctic University of Norway https://hdl.handle.net/10037/19759 openAccess Copyright 2019 The Author(s) VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 MED-3910 Master thesis Mastergradsoppgave 2019 ftunivtroemsoe 2021-06-25T17:57:46Z Venous thromboembolism is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of venous thromboembolism, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of venous thromboembolism. Cases with incident venous thromboembolism (n= 640) and a randomly selected age-weighted sub-cohort (n=3734) were derived from a population-based cohort (the Tromsø study). Cox-regression was used to estimate hazard ratios with 95% confidence intervals for VTE according to categories of cancer and FGG. In those without cancer, homozygosity at the FGG variant was associated with a 70% (HR 1.7 95% CI 1.2-2.3) increased risk of venous thromboembolism compared to non-carriers. Cancer patients homozygous for the FGG variant had a 2-fold (HR 2.0 95% CI 1.1-3.6) higher risk of venous thromboembolism than cancer patients without the variant. Moreover, the 6-month cumulative incidence of venous thromboembolism among cancer patients was 6.4% (95% CI, 3.5%-11.6%) in homozygous carriers of FGG and 3.1% (95% CI, 2.3%-4.7%) in those without risk alleles. A synergistic effect was observed between rs2066865 and active cancer on the risk of VTE (Synergy index: 1.81, 95% CI: 1.02-3.21, Attributable proportion: 0.43, 95% CI: 0.11-0.74). In conclusion, homozygosity at the FGG variant and active cancer yielded synergistic effect on the risk of venous thromboembolism. Master Thesis Tromsø University of Tromsø: Munin Open Research Archive Tromsø |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 MED-3910 |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 MED-3910 Paulsen, Benedikte Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 MED-3910 |
description |
Venous thromboembolism is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of venous thromboembolism, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of venous thromboembolism. Cases with incident venous thromboembolism (n= 640) and a randomly selected age-weighted sub-cohort (n=3734) were derived from a population-based cohort (the Tromsø study). Cox-regression was used to estimate hazard ratios with 95% confidence intervals for VTE according to categories of cancer and FGG. In those without cancer, homozygosity at the FGG variant was associated with a 70% (HR 1.7 95% CI 1.2-2.3) increased risk of venous thromboembolism compared to non-carriers. Cancer patients homozygous for the FGG variant had a 2-fold (HR 2.0 95% CI 1.1-3.6) higher risk of venous thromboembolism than cancer patients without the variant. Moreover, the 6-month cumulative incidence of venous thromboembolism among cancer patients was 6.4% (95% CI, 3.5%-11.6%) in homozygous carriers of FGG and 3.1% (95% CI, 2.3%-4.7%) in those without risk alleles. A synergistic effect was observed between rs2066865 and active cancer on the risk of VTE (Synergy index: 1.81, 95% CI: 1.02-3.21, Attributable proportion: 0.43, 95% CI: 0.11-0.74). In conclusion, homozygosity at the FGG variant and active cancer yielded synergistic effect on the risk of venous thromboembolism. |
format |
Master Thesis |
author |
Paulsen, Benedikte |
author_facet |
Paulsen, Benedikte |
author_sort |
Paulsen, Benedikte |
title |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_short |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_full |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_fullStr |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_full_unstemmed |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_sort |
fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
publisher |
UiT Norges arktiske universitet |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/19759 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://hdl.handle.net/10037/19759 |
op_rights |
openAccess Copyright 2019 The Author(s) |
_version_ |
1766219673487015936 |