The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death
Conference web site at https://www.eaa2020.org/ . The marine natural product mimic MHP 88 is a novel synthetic molecule based on unique structures found in molecules from an arctic marine bryozoan. Initial studies showed that MHP88 kills cancer cells efficiently, but is not hemolytic. In this study,...
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ftunivtroemsoe:oai:munin.uit.no:10037/19579 2023-05-15T15:07:30+02:00 The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death von Hofsten, Susannah Norvoll Magnussen, Synnøve Ausbacher, Dominik Paulsen, Marianne Hagensen Bayer, Annette Strøm, Morten B. Berge, Gerd 2020-03 https://hdl.handle.net/10037/19579 eng eng von Hofsten, S., Norvoll Magnussen, S., Ausbacher, D., Paulsen, M.H., Bayer, A., Strøm, M.B. & Berge, G. (2020). The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death [Poster presentation]. EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microenvironment, Lisboa, Portugal, 2 – 4 March 2020 . FRIDAID 1826288 https://hdl.handle.net/10037/19579 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 Conference object Konferansebidrag 2020 ftunivtroemsoe 2021-06-25T17:57:39Z Conference web site at https://www.eaa2020.org/ . The marine natural product mimic MHP 88 is a novel synthetic molecule based on unique structures found in molecules from an arctic marine bryozoan. Initial studies showed that MHP88 kills cancer cells efficiently, but is not hemolytic. In this study, we look closer at the mode of death induced by MHP88 in oral cancer (HSC-3) and lymphoma (Ramos) cell lines. Immunogenic cell death (ICD) is a mode of death that can be induced by some anticancer molecules and is characterized by the release and expression of certain damage associated molecular patterns (DAMPs) which have immune stimulating effects. Specifically, the release of high mobility group box 1 (HMGB1) and ATP, as well as the translocation of calreticulin from the ER lumen to the outside of the cell membrane, constitute the major hallmarks of ICD. In vivo ICD induced in cancer cells has a vaccination effect, protecting the host from future challenge with the same cancer cells. Animal studies on the molecule LTX-401, which has similar properties as MHP88 have successfully demonstrated this effect. Conference Object Arctic University of Tromsø: Munin Open Research Archive Arctic Ramos ENVELOPE(-59.700,-59.700,-62.500,-62.500) |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 von Hofsten, Susannah Norvoll Magnussen, Synnøve Ausbacher, Dominik Paulsen, Marianne Hagensen Bayer, Annette Strøm, Morten B. Berge, Gerd The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 |
description |
Conference web site at https://www.eaa2020.org/ . The marine natural product mimic MHP 88 is a novel synthetic molecule based on unique structures found in molecules from an arctic marine bryozoan. Initial studies showed that MHP88 kills cancer cells efficiently, but is not hemolytic. In this study, we look closer at the mode of death induced by MHP88 in oral cancer (HSC-3) and lymphoma (Ramos) cell lines. Immunogenic cell death (ICD) is a mode of death that can be induced by some anticancer molecules and is characterized by the release and expression of certain damage associated molecular patterns (DAMPs) which have immune stimulating effects. Specifically, the release of high mobility group box 1 (HMGB1) and ATP, as well as the translocation of calreticulin from the ER lumen to the outside of the cell membrane, constitute the major hallmarks of ICD. In vivo ICD induced in cancer cells has a vaccination effect, protecting the host from future challenge with the same cancer cells. Animal studies on the molecule LTX-401, which has similar properties as MHP88 have successfully demonstrated this effect. |
format |
Conference Object |
author |
von Hofsten, Susannah Norvoll Magnussen, Synnøve Ausbacher, Dominik Paulsen, Marianne Hagensen Bayer, Annette Strøm, Morten B. Berge, Gerd |
author_facet |
von Hofsten, Susannah Norvoll Magnussen, Synnøve Ausbacher, Dominik Paulsen, Marianne Hagensen Bayer, Annette Strøm, Morten B. Berge, Gerd |
author_sort |
von Hofsten, Susannah |
title |
The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death |
title_short |
The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death |
title_full |
The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death |
title_fullStr |
The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death |
title_full_unstemmed |
The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death |
title_sort |
marine natural product mimic mhp88 shows anticancer activity and has the potential to cause immunogenic cell death |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/19579 |
long_lat |
ENVELOPE(-59.700,-59.700,-62.500,-62.500) |
geographic |
Arctic Ramos |
geographic_facet |
Arctic Ramos |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
von Hofsten, S., Norvoll Magnussen, S., Ausbacher, D., Paulsen, M.H., Bayer, A., Strøm, M.B. & Berge, G. (2020). The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death [Poster presentation]. EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microenvironment, Lisboa, Portugal, 2 – 4 March 2020 . FRIDAID 1826288 https://hdl.handle.net/10037/19579 |
op_rights |
openAccess Copyright 2020 The Author(s) |
_version_ |
1766338987158405120 |