Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study
Background - The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patie...
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Online Access: | https://hdl.handle.net/10037/18582 https://doi.org/10.1002/rth2.12306 |
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ftunivtroemsoe:oai:munin.uit.no:10037/18582 2023-05-15T18:34:28+02:00 Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study Sejrup, Joakim Knutsen Morelli, Vania Maris Løchen, Maja-Lisa Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Hansen, John-Bjarne Brækkan, Sigrid Kufaas 2020-01-27 https://hdl.handle.net/10037/18582 https://doi.org/10.1002/rth2.12306 eng eng Wiley Research and Practice in Thrombosis and Haemostasis Sejrup JK, Morelli VM, Løchen M, Njølstad i, Mathiesen EB, Wilsgaard T, Hansen JB, Brækkan SK. Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study. Research and Practice in Thrombosis and Haemostasis. 2020;4(2):247-254 FRIDAID 1808083 doi:10.1002/rth2.12306 2475-0379 https://hdl.handle.net/10037/18582 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Journal article Tidsskriftartikkel Peer reviewed Master thesis Mastergradsoppgave publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1002/rth2.12306 2022-11-03T00:01:18Z Background - The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated. Aim - To study the combined effect of MI and prothrombotic SNPs on the risk of VTE. Methods - Cases with incident VTE (n = 641) and a randomly sampled subcohort weighted for age (n = 1761) were identified from the 4 to 6 surveys of the Tromsø Study (1994‐2012). DNA was genotyped for rs8176719 ( ABO ), rs6025 ( F5 ), rs1799963 ( F2 ), rs2066865 ( FGG ), and rs2036914 ( F11 ). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) were estimated by categories of risk alleles and MI status. Results - Patients with MI had a 1.4‐fold increased risk of VTE, and adjustments for the 5 SNPs, either alone or in combination, did not affect this relationship (adjusted HR, 1.52; 95% CI, 1.12‐2.07). In subjects without MI, an increased risk of VTE was observed for each of the individual SNPs (≥1 vs. 0 risk alleles), and the risk increased linearly with increasing number of risk alleles in the 5‐SNP score. The combination of MI and prothrombotic genotypes, either as individual SNPs or in the 5‐SNP score, did not result in an excess risk of VTE. Conclusion - The relationship between MI and VTE was not explained by these 5 prothrombotic genotypes. Prothrombotic genotypes did not yield an excess risk of VTE in patients with MI. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Research and Practice in Thrombosis and Haemostasis 4 2 247 254 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Sejrup, Joakim Knutsen Morelli, Vania Maris Løchen, Maja-Lisa Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Hansen, John-Bjarne Brækkan, Sigrid Kufaas Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 |
description |
Background - The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated. Aim - To study the combined effect of MI and prothrombotic SNPs on the risk of VTE. Methods - Cases with incident VTE (n = 641) and a randomly sampled subcohort weighted for age (n = 1761) were identified from the 4 to 6 surveys of the Tromsø Study (1994‐2012). DNA was genotyped for rs8176719 ( ABO ), rs6025 ( F5 ), rs1799963 ( F2 ), rs2066865 ( FGG ), and rs2036914 ( F11 ). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) were estimated by categories of risk alleles and MI status. Results - Patients with MI had a 1.4‐fold increased risk of VTE, and adjustments for the 5 SNPs, either alone or in combination, did not affect this relationship (adjusted HR, 1.52; 95% CI, 1.12‐2.07). In subjects without MI, an increased risk of VTE was observed for each of the individual SNPs (≥1 vs. 0 risk alleles), and the risk increased linearly with increasing number of risk alleles in the 5‐SNP score. The combination of MI and prothrombotic genotypes, either as individual SNPs or in the 5‐SNP score, did not result in an excess risk of VTE. Conclusion - The relationship between MI and VTE was not explained by these 5 prothrombotic genotypes. Prothrombotic genotypes did not yield an excess risk of VTE in patients with MI. |
format |
Article in Journal/Newspaper |
author |
Sejrup, Joakim Knutsen Morelli, Vania Maris Løchen, Maja-Lisa Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Hansen, John-Bjarne Brækkan, Sigrid Kufaas |
author_facet |
Sejrup, Joakim Knutsen Morelli, Vania Maris Løchen, Maja-Lisa Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Hansen, John-Bjarne Brækkan, Sigrid Kufaas |
author_sort |
Sejrup, Joakim Knutsen |
title |
Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study |
title_short |
Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study |
title_full |
Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study |
title_fullStr |
Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study |
title_full_unstemmed |
Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study |
title_sort |
myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: the tromsø study |
publisher |
Wiley |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/18582 https://doi.org/10.1002/rth2.12306 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Research and Practice in Thrombosis and Haemostasis Sejrup JK, Morelli VM, Løchen M, Njølstad i, Mathiesen EB, Wilsgaard T, Hansen JB, Brækkan SK. Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study. Research and Practice in Thrombosis and Haemostasis. 2020;4(2):247-254 FRIDAID 1808083 doi:10.1002/rth2.12306 2475-0379 https://hdl.handle.net/10037/18582 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1002/rth2.12306 |
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Research and Practice in Thrombosis and Haemostasis |
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4 |
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2 |
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247 |
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