Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds
Background - Uncontrolled hypertension is a major cardiovascular risk factor. We examined uncontrolled hypertension and differences in treatment regimens between a high-risk country, Russia, and low-risk Norway to gain better understanding of the underlying factors. Methods - Population-based survey...
Published in: | BMC Cardiovascular Disorders |
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Online Access: | https://hdl.handle.net/10037/18525 https://doi.org/10.1186/s12872-020-01407-2 |
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ftunivtroemsoe:oai:munin.uit.no:10037/18525 2023-05-15T18:34:00+02:00 Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew 2020-03-13 https://hdl.handle.net/10037/18525 https://doi.org/10.1186/s12872-020-01407-2 eng eng BMC BMC Cardiovascular Disorders Petersen, Malyutina S, Ryabikov A, Kontsevaya A, Kudryavtsev AV, Eggen AE, McKee M, Cook SA, Hopstock LA, Schirmer H, Leon DA. Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds. BMC Cardiovascular Disorders. 2020;20:135:1-11 FRIDAID 1808962 doi:10.1186/s12872-020-01407-2 1471-2261 https://hdl.handle.net/10037/18525 openAccess Copyright 2020 The Author(s) VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2020 ftunivtroemsoe https://doi.org/10.1186/s12872-020-01407-2 2021-06-25T17:57:31Z Background - Uncontrolled hypertension is a major cardiovascular risk factor. We examined uncontrolled hypertension and differences in treatment regimens between a high-risk country, Russia, and low-risk Norway to gain better understanding of the underlying factors. Methods - Population-based survey data on 40–69 year olds with hypertension defined as taking antihypertensives and/or having high blood pressure (140+/90+ mmHg) were obtained from Know Your Heart Study (KYH, N = 2284), Russian Federation (2015–2018) and seventh wave of The Tromsø Study (Tromsø 7, N = 5939), Norway (2015–2016). Uncontrolled hypertension was studied in the subset taking antihypertensives (KYH: N = 1584; Tromsø 7: 2792)and defined as having high blood pressure (140+/90+ mmHg). Apparent treatment resistant hypertension (aTRH) was defined as individuals with uncontrolled hypertension on 3+ OR controlled on 4+ antihypertensive classes in the same subset. Results - Among all those with hypertension regardless of treatment status, control of blood pressure was achieved in 22% of men (KYH and Tromsø 7), while among women it was 33% in Tromsø 7 and 43% in KYH. When the analysis was limited to those on treatment for hypertension, the percentage uncontrolled was higher in KYH (47.8%, CI 95 44.6–50.9%) than Tromsø 7 (38.2, 36.1–40.5%). The corresponding figures for aTRH were 9.8% (8.2–11.7%) and 5.7% (4.8–6.8%). Antihypertensive monotherapies were more common than combinations and used by 58% in Tromsø 7 and 44% in KYH. In both KYH and Tromsø 7, untreated hypertension was higher in men, those with no GP visit in the past year and problem drinkers. In both studies, aTRH was associated with older age, CVD history, obesity, and diabetes. In Tromsø 7, also male gender and any drinking. In KYH, also chronic kidney disease. Conclusion - There is considerable scope for promoting combination therapies in line with European treatment guidelines in both study populations. The factors associated with untreated hypertension overlap with known correlates of treatment non-adherence and health check non-attendance. In contrast, aTRH was characterised by obesity and underlying comorbidities potentially complicating treatment. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø BMC Cardiovascular Disorders 20 1 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
spellingShingle |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
topic_facet |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
description |
Background - Uncontrolled hypertension is a major cardiovascular risk factor. We examined uncontrolled hypertension and differences in treatment regimens between a high-risk country, Russia, and low-risk Norway to gain better understanding of the underlying factors. Methods - Population-based survey data on 40–69 year olds with hypertension defined as taking antihypertensives and/or having high blood pressure (140+/90+ mmHg) were obtained from Know Your Heart Study (KYH, N = 2284), Russian Federation (2015–2018) and seventh wave of The Tromsø Study (Tromsø 7, N = 5939), Norway (2015–2016). Uncontrolled hypertension was studied in the subset taking antihypertensives (KYH: N = 1584; Tromsø 7: 2792)and defined as having high blood pressure (140+/90+ mmHg). Apparent treatment resistant hypertension (aTRH) was defined as individuals with uncontrolled hypertension on 3+ OR controlled on 4+ antihypertensive classes in the same subset. Results - Among all those with hypertension regardless of treatment status, control of blood pressure was achieved in 22% of men (KYH and Tromsø 7), while among women it was 33% in Tromsø 7 and 43% in KYH. When the analysis was limited to those on treatment for hypertension, the percentage uncontrolled was higher in KYH (47.8%, CI 95 44.6–50.9%) than Tromsø 7 (38.2, 36.1–40.5%). The corresponding figures for aTRH were 9.8% (8.2–11.7%) and 5.7% (4.8–6.8%). Antihypertensive monotherapies were more common than combinations and used by 58% in Tromsø 7 and 44% in KYH. In both KYH and Tromsø 7, untreated hypertension was higher in men, those with no GP visit in the past year and problem drinkers. In both studies, aTRH was associated with older age, CVD history, obesity, and diabetes. In Tromsø 7, also male gender and any drinking. In KYH, also chronic kidney disease. Conclusion - There is considerable scope for promoting combination therapies in line with European treatment guidelines in both study populations. The factors associated with untreated hypertension overlap with known correlates of treatment non-adherence and health check non-attendance. In contrast, aTRH was characterised by obesity and underlying comorbidities potentially complicating treatment. |
format |
Article in Journal/Newspaper |
author |
Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew |
author_facet |
Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew |
author_sort |
Petersen, Jakob |
title |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_short |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_full |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_fullStr |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_full_unstemmed |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_sort |
uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of russian and norwegian 40–69 year olds |
publisher |
BMC |
publishDate |
2020 |
url |
https://hdl.handle.net/10037/18525 https://doi.org/10.1186/s12872-020-01407-2 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMC Cardiovascular Disorders Petersen, Malyutina S, Ryabikov A, Kontsevaya A, Kudryavtsev AV, Eggen AE, McKee M, Cook SA, Hopstock LA, Schirmer H, Leon DA. Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds. BMC Cardiovascular Disorders. 2020;20:135:1-11 FRIDAID 1808962 doi:10.1186/s12872-020-01407-2 1471-2261 https://hdl.handle.net/10037/18525 |
op_rights |
openAccess Copyright 2020 The Author(s) |
op_doi |
https://doi.org/10.1186/s12872-020-01407-2 |
container_title |
BMC Cardiovascular Disorders |
container_volume |
20 |
container_issue |
1 |
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1766218647866441728 |