Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism
Background - Limited knowledge exists on the association between intake of long-chained n-3 polyunsaturated fatty acids (n-3 PUFAs) and risk of recurrence and all-cause mortality in patients with venous thromboembolism (VTE). Objectives - This article investigates whether intake of marine n-3 PUFAs...
Published in: | Thrombosis and Haemostasis |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Thieme Publishing
2019
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/18156 https://doi.org/10.1055/s-0039-1697663 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/18156 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/18156 2023-05-15T18:34:49+02:00 Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism Isaksen, Trond Evensen, Line Holtet Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2019-10-28 https://hdl.handle.net/10037/18156 https://doi.org/10.1055/s-0039-1697663 eng eng Thieme Publishing Isaksen, T. (2020). Dietary intake of marine polyunsaturated fatty acids and incidence, recurrence and mortality related to venous thromboembolism. (Doctoral thesis). https://hdl.handle.net/10037/19730 . Thrombosis and Haemostasis Isaksen T, Evensen L, Brækkan SK, Hansen JB. Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism. Thrombosis and Haemostasis. 2019;119(12):2053-2063 FRIDAID 1770164 doi:10.1055/s-0039-1697663 0340-6245 https://hdl.handle.net/10037/18156 openAccess © 2019 Georg Thieme Verlag KG VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Journal article Tidsskriftartikkel Peer reviewed acceptedVersion 2019 ftunivtroemsoe https://doi.org/10.1055/s-0039-1697663 2021-06-25T17:57:20Z Background - Limited knowledge exists on the association between intake of long-chained n-3 polyunsaturated fatty acids (n-3 PUFAs) and risk of recurrence and all-cause mortality in patients with venous thromboembolism (VTE). Objectives - This article investigates whether intake of marine n-3 PUFAs was associated with risk of recurrence and mortality in patients with incident VTE. Methods - A total of 595 patients with incident VTE and available data on n-3 PUFA intake were derived from the Tromsø Study surveys 4 (1994–1995) and 6 (2007–2008). Weekly intake of n-3 PUFAs was categorized as low, medium, and high based on tertiles. Recurrent VTEs and all-cause mortality were registered up to December 31, 2016. Hazard ratios (HRs) were calculated using Cox regression models with the low intake category as reference. Results - There were 98 recurrent VTEs and 227 deaths during follow-up. Overall, we found no association between intake of n-3 PUFAs and risk of recurrent VTE. However, inverse associations were found for high intakes in patients with unprovoked VTE (HR 0.45, 95% confidence interval [CI]: 0.20–1.01), cancer-free patients (HR 0.51, 95% CI: 0.27–0.95), and deep vein thrombosis (DVT) patients (HR 0.49, 95% CI: 0.24–0.97). The inverse associations were more evident when follow-up was restricted to the time after discontinuation of anticoagulant therapy. No association was observed between intake of n-3 PUFAs and mortality after incident VTE. Conclusion - A high dietary intake of marine n-3 PUFAs was associated with lower risk of recurrent VTE after unprovoked index events, DVT, and in cancer-free patients. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Thrombosis and Haemostasis 119 12 2053 2063 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
spellingShingle |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Isaksen, Trond Evensen, Line Holtet Brækkan, Sigrid Kufaas Hansen, John-Bjarne Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism |
topic_facet |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
description |
Background - Limited knowledge exists on the association between intake of long-chained n-3 polyunsaturated fatty acids (n-3 PUFAs) and risk of recurrence and all-cause mortality in patients with venous thromboembolism (VTE). Objectives - This article investigates whether intake of marine n-3 PUFAs was associated with risk of recurrence and mortality in patients with incident VTE. Methods - A total of 595 patients with incident VTE and available data on n-3 PUFA intake were derived from the Tromsø Study surveys 4 (1994–1995) and 6 (2007–2008). Weekly intake of n-3 PUFAs was categorized as low, medium, and high based on tertiles. Recurrent VTEs and all-cause mortality were registered up to December 31, 2016. Hazard ratios (HRs) were calculated using Cox regression models with the low intake category as reference. Results - There were 98 recurrent VTEs and 227 deaths during follow-up. Overall, we found no association between intake of n-3 PUFAs and risk of recurrent VTE. However, inverse associations were found for high intakes in patients with unprovoked VTE (HR 0.45, 95% confidence interval [CI]: 0.20–1.01), cancer-free patients (HR 0.51, 95% CI: 0.27–0.95), and deep vein thrombosis (DVT) patients (HR 0.49, 95% CI: 0.24–0.97). The inverse associations were more evident when follow-up was restricted to the time after discontinuation of anticoagulant therapy. No association was observed between intake of n-3 PUFAs and mortality after incident VTE. Conclusion - A high dietary intake of marine n-3 PUFAs was associated with lower risk of recurrent VTE after unprovoked index events, DVT, and in cancer-free patients. |
format |
Article in Journal/Newspaper |
author |
Isaksen, Trond Evensen, Line Holtet Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Isaksen, Trond Evensen, Line Holtet Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Isaksen, Trond |
title |
Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism |
title_short |
Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism |
title_full |
Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism |
title_fullStr |
Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism |
title_full_unstemmed |
Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism |
title_sort |
dietary intake of marine polyunsaturated n-3 fatty acids and risk of recurrent venous thromboembolism |
publisher |
Thieme Publishing |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/18156 https://doi.org/10.1055/s-0039-1697663 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Isaksen, T. (2020). Dietary intake of marine polyunsaturated fatty acids and incidence, recurrence and mortality related to venous thromboembolism. (Doctoral thesis). https://hdl.handle.net/10037/19730 . Thrombosis and Haemostasis Isaksen T, Evensen L, Brækkan SK, Hansen JB. Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism. Thrombosis and Haemostasis. 2019;119(12):2053-2063 FRIDAID 1770164 doi:10.1055/s-0039-1697663 0340-6245 https://hdl.handle.net/10037/18156 |
op_rights |
openAccess © 2019 Georg Thieme Verlag KG |
op_doi |
https://doi.org/10.1055/s-0039-1697663 |
container_title |
Thrombosis and Haemostasis |
container_volume |
119 |
container_issue |
12 |
container_start_page |
2053 |
op_container_end_page |
2063 |
_version_ |
1766219757837615104 |