Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway
Background: Exposure to environmental pollutants may contribute to the development of asthma and other allergies. The aim of this study was to investigate possible associations between asthma and other allergies with exposure to perfluoroalkyl substances (PFASs) in adolescents from the Arctic region...
Published in: | Environmental Research |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Elsevier
2019
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/18081 https://doi.org/10.1016/j.envres.2018.11.005 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/18081 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/18081 2023-05-15T15:13:00+02:00 Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway Averina, Maria Brox, Jan Huber, Sandra Furberg, Anne-Sofie Sørensen, Martin 2019 https://hdl.handle.net/10037/18081 https://doi.org/10.1016/j.envres.2018.11.005 eng eng Elsevier Environmental Research Averina, M.; Brox, J,; Huber, S.H.; Furberg, A-S.; Sørensen, M. (2019) Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway. Environmental Research, 2019, ,169, 114-121. FRIDAID 1630606 doi:10.1016/j.envres.2018.11.005 0013-9351 1096-0953 https://hdl.handle.net/10037/18081 openAccess © Elsevier Inc. All rights reserved VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 Journal article Tidsskriftartikkel Peer reviewed acceptedVersion 2019 ftunivtroemsoe https://doi.org/10.1016/j.envres.2018.11.005 2021-06-25T17:57:18Z Background: Exposure to environmental pollutants may contribute to the development of asthma and other allergies. The aim of this study was to investigate possible associations between asthma and other allergies with exposure to perfluoroalkyl substances (PFASs) in adolescents from the Arctic region of Norway. Methods The Tromsø study Fit Futures 1 (TFF1) and 3-year follow-up Fit Futures 2 study (TFF2) included 675 adolescents that completed a questionnaire about health conditions and underwent a clinical examination with blood tests and fractional nitric oxide (FeNO) measurement. Serum concentrations of 18 PFASs were measured by UHPLC-MS/MS method. Results Total PFASs (ΣPFAS) serum concentration over 4th quartile was positively associated with asthma in the TFF1 (OR 3.35 (95% CI 1.54–7.29), p = 0.002). Total perfluorooctane sulfonate (ΣPFOS), linear PFOS (linPFOS), linear perfluorohexane sulfonate (linPFHxS) concentrations over 4th quartiles were associated with 2 times higher odds of asthma in the TFF1. The positive associations between ΣPFAS, ΣPFOS, linPFOS and asthma remained statistically significant in the TFF2. ΣPFAS and linPFHxS concentrations over 3rd tertiles were associated with positive marker of eosinophilic airways inflammation FeNO> 25 ppb. Concentrations of ΣPFOS and linPFOS over 3rd quartiles were positively associated with self-reported nickel allergy (OR 2.25 (95% CI 1.17–4.35) p = 0.016 and OR 2.53 (95% CI 1.30–4.90) p = 0.006, respectively). Allergic rhinitis, self-reported pollen allergy, food allergy and atopic eczema were not associated with PFASs concentrations. Conclusions This study of Norwegian adolescents showed a positive association between several PFASs and asthma, as well as between PFOS and nickel allergy. Article in Journal/Newspaper Arctic Northern Norway Tromsø University of Tromsø: Munin Open Research Archive Arctic Norway Tromsø Environmental Research 169 114 121 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 Averina, Maria Brox, Jan Huber, Sandra Furberg, Anne-Sofie Sørensen, Martin Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 |
description |
Background: Exposure to environmental pollutants may contribute to the development of asthma and other allergies. The aim of this study was to investigate possible associations between asthma and other allergies with exposure to perfluoroalkyl substances (PFASs) in adolescents from the Arctic region of Norway. Methods The Tromsø study Fit Futures 1 (TFF1) and 3-year follow-up Fit Futures 2 study (TFF2) included 675 adolescents that completed a questionnaire about health conditions and underwent a clinical examination with blood tests and fractional nitric oxide (FeNO) measurement. Serum concentrations of 18 PFASs were measured by UHPLC-MS/MS method. Results Total PFASs (ΣPFAS) serum concentration over 4th quartile was positively associated with asthma in the TFF1 (OR 3.35 (95% CI 1.54–7.29), p = 0.002). Total perfluorooctane sulfonate (ΣPFOS), linear PFOS (linPFOS), linear perfluorohexane sulfonate (linPFHxS) concentrations over 4th quartiles were associated with 2 times higher odds of asthma in the TFF1. The positive associations between ΣPFAS, ΣPFOS, linPFOS and asthma remained statistically significant in the TFF2. ΣPFAS and linPFHxS concentrations over 3rd tertiles were associated with positive marker of eosinophilic airways inflammation FeNO> 25 ppb. Concentrations of ΣPFOS and linPFOS over 3rd quartiles were positively associated with self-reported nickel allergy (OR 2.25 (95% CI 1.17–4.35) p = 0.016 and OR 2.53 (95% CI 1.30–4.90) p = 0.006, respectively). Allergic rhinitis, self-reported pollen allergy, food allergy and atopic eczema were not associated with PFASs concentrations. Conclusions This study of Norwegian adolescents showed a positive association between several PFASs and asthma, as well as between PFOS and nickel allergy. |
format |
Article in Journal/Newspaper |
author |
Averina, Maria Brox, Jan Huber, Sandra Furberg, Anne-Sofie Sørensen, Martin |
author_facet |
Averina, Maria Brox, Jan Huber, Sandra Furberg, Anne-Sofie Sørensen, Martin |
author_sort |
Averina, Maria |
title |
Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway |
title_short |
Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway |
title_full |
Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway |
title_fullStr |
Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway |
title_full_unstemmed |
Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway |
title_sort |
serum perfluoroalkyl substances (pfas)and risk of various allergies in adolescents. the tromsø study fit futures in northern norway |
publisher |
Elsevier |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/18081 https://doi.org/10.1016/j.envres.2018.11.005 |
geographic |
Arctic Norway Tromsø |
geographic_facet |
Arctic Norway Tromsø |
genre |
Arctic Northern Norway Tromsø |
genre_facet |
Arctic Northern Norway Tromsø |
op_relation |
Environmental Research Averina, M.; Brox, J,; Huber, S.H.; Furberg, A-S.; Sørensen, M. (2019) Serum perfluoroalkyl substances (PFAS)and risk of various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway. Environmental Research, 2019, ,169, 114-121. FRIDAID 1630606 doi:10.1016/j.envres.2018.11.005 0013-9351 1096-0953 https://hdl.handle.net/10037/18081 |
op_rights |
openAccess © Elsevier Inc. All rights reserved |
op_doi |
https://doi.org/10.1016/j.envres.2018.11.005 |
container_title |
Environmental Research |
container_volume |
169 |
container_start_page |
114 |
op_container_end_page |
121 |
_version_ |
1766343603618054144 |