Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study
Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors in...
Published in: | Thrombosis and Haemostasis |
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Online Access: | https://hdl.handle.net/10037/17930 https://doi.org/10.1055/s-0039-1692176 |
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ftunivtroemsoe:oai:munin.uit.no:10037/17930 2023-05-15T18:34:48+02:00 Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study Sejrup, Joakim Knutsen Børvik, Trond Grimnes, Gro Isaksen, Trond Hindberg, Kristian Hansen, John-Bjarne Morelli, Vania Maris Brækkan, Sigrid Kufaas 2019-06-16 https://hdl.handle.net/10037/17930 https://doi.org/10.1055/s-0039-1692176 eng eng Thieme Publishing Sejrup, J.K. (2022). Risk Factors and Triggers of Venous Thromboembolism in Patients with Myocardial Infarction. (Doctoral thesis). https://hdl.handle.net/10037/25377 . Thrombosis and Haemostasis Sejrup JK, Børvik T, Grimnes G, Isaksen T, Hindberg K, Hansen JB, Morelli VM, Brækkan SK. Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study. Thrombosis and Haemostasis. 2019;119(8):1358-1364 FRIDAID 1709292 doi:10.1055/s-0039-1692176 0340-6245 https://hdl.handle.net/10037/17930 openAccess Copyright © 2019, Rights Managed by Georg Thieme Verlag KG Stuttgart • New York VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Journal article Tidsskriftartikkel Peer reviewed acceptedVersion 2019 ftunivtroemsoe https://doi.org/10.1055/s-0039-1692176 2022-06-08T22:58:57Z Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients ( n = 707) recruited from the fourth survey of the Tromsø Study. VTE risk factors and hospitalizations were registered during the 90-day period preceding the VTE diagnosis (hazard period) and in four 90-day control periods. Conditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for VTE according to acute MI and after adjustment for other risk factors. Additionally, we applied a mediation analysis to quantify how much the known transient risk factors account for the observed effect of MI on VTE risk. MI was recorded in 13 (1.8%) of the hazard periods and in 6 (0.2%) of the control periods, which yielded a crude OR of 11.9 (95% CI: 3.9–36.7). Adjustment for immobilization and infection yielded an OR of 2.7 (95% CI: 0.6–11.2). The OR was attenuated to 2.6 (95% CI: 0.6–11.9) after further adjustment for major surgery, trauma, red blood cell transfusion, and central venous catheterization. Approximately 60% of the association between MI and VTE was mediated through infection and immobilization. In conclusion, our findings suggest that the increased VTE risk after MI may to a large extent be explained by concomitant conditions related to MI, particularly infections and immobilization. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Thrombosis and Haemostasis 119 08 1358 1364 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
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VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Sejrup, Joakim Knutsen Børvik, Trond Grimnes, Gro Isaksen, Trond Hindberg, Kristian Hansen, John-Bjarne Morelli, Vania Maris Brækkan, Sigrid Kufaas Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study |
topic_facet |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
description |
Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients ( n = 707) recruited from the fourth survey of the Tromsø Study. VTE risk factors and hospitalizations were registered during the 90-day period preceding the VTE diagnosis (hazard period) and in four 90-day control periods. Conditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for VTE according to acute MI and after adjustment for other risk factors. Additionally, we applied a mediation analysis to quantify how much the known transient risk factors account for the observed effect of MI on VTE risk. MI was recorded in 13 (1.8%) of the hazard periods and in 6 (0.2%) of the control periods, which yielded a crude OR of 11.9 (95% CI: 3.9–36.7). Adjustment for immobilization and infection yielded an OR of 2.7 (95% CI: 0.6–11.2). The OR was attenuated to 2.6 (95% CI: 0.6–11.9) after further adjustment for major surgery, trauma, red blood cell transfusion, and central venous catheterization. Approximately 60% of the association between MI and VTE was mediated through infection and immobilization. In conclusion, our findings suggest that the increased VTE risk after MI may to a large extent be explained by concomitant conditions related to MI, particularly infections and immobilization. |
format |
Article in Journal/Newspaper |
author |
Sejrup, Joakim Knutsen Børvik, Trond Grimnes, Gro Isaksen, Trond Hindberg, Kristian Hansen, John-Bjarne Morelli, Vania Maris Brækkan, Sigrid Kufaas |
author_facet |
Sejrup, Joakim Knutsen Børvik, Trond Grimnes, Gro Isaksen, Trond Hindberg, Kristian Hansen, John-Bjarne Morelli, Vania Maris Brækkan, Sigrid Kufaas |
author_sort |
Sejrup, Joakim Knutsen |
title |
Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study |
title_short |
Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study |
title_full |
Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study |
title_fullStr |
Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study |
title_full_unstemmed |
Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study |
title_sort |
myocardial infarction as a transient risk factor for incident venous thromboembolism: results from a population-based case-crossover study |
publisher |
Thieme Publishing |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/17930 https://doi.org/10.1055/s-0039-1692176 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Sejrup, J.K. (2022). Risk Factors and Triggers of Venous Thromboembolism in Patients with Myocardial Infarction. (Doctoral thesis). https://hdl.handle.net/10037/25377 . Thrombosis and Haemostasis Sejrup JK, Børvik T, Grimnes G, Isaksen T, Hindberg K, Hansen JB, Morelli VM, Brækkan SK. Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study. Thrombosis and Haemostasis. 2019;119(8):1358-1364 FRIDAID 1709292 doi:10.1055/s-0039-1692176 0340-6245 https://hdl.handle.net/10037/17930 |
op_rights |
openAccess Copyright © 2019, Rights Managed by Georg Thieme Verlag KG Stuttgart • New York |
op_doi |
https://doi.org/10.1055/s-0039-1692176 |
container_title |
Thrombosis and Haemostasis |
container_volume |
119 |
container_issue |
08 |
container_start_page |
1358 |
op_container_end_page |
1364 |
_version_ |
1766219731715489792 |