Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism
This is the peer reviewed version of the following article: Småbrekke, B., Rinde, L., Evensen, L., Morelli, V., Hveem, K., Gabrielsen, M., . Hansen, J. (2019). Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism. Journal of...
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Online Access: | https://hdl.handle.net/10037/17265 https://doi.org/10.1111/jth.14493 |
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ftunivtroemsoe:oai:munin.uit.no:10037/17265 2023-05-15T18:35:00+02:00 Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism Småbrekke, Birgit Balteskard Rinde, Ludvig Evensen, Line Holtet Morelli, Vania Maris Hveem, Kristian Gabrielsen, Maiken Elvestad Njølstad, Inger Mathiesen, Ellisiv B. Rosendaal, Frits Richard Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2019-05-24 https://hdl.handle.net/10037/17265 https://doi.org/10.1111/jth.14493 eng eng Wiley Journal of Thrombosis and Haemostasis Stiftelsen Kristian Gerhard Jebsen: SKGJ-MED-015 Norges forskningsråd: 248817 info:eu-repo/grantAgreement/RCN/BEHANDLING/248817/Norway/National training initiative to make better use of biobanks and health registry data// Småbrekke B, Balteskard Rinde LBR, Evensen L, Morelli VM, Hveem K, Gabrielsen ME, Njølstad i, Mathiesen EB, Rosendaal FR, Brækkan SK, Hansen JB. Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism. Journal of Thrombosis and Haemostasis. 2019:1-9 FRIDAID 1700766 doi:10.1111/jth.14493 1538-7933 1538-7836 https://hdl.handle.net/10037/17265 openAccess © 2019 International Society on Thrombosis and Haemostasis VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Journal article Tidsskriftartikkel Peer reviewed acceptedVersion 2019 ftunivtroemsoe https://doi.org/10.1111/jth.14493 2021-06-25T17:57:01Z This is the peer reviewed version of the following article: Småbrekke, B., Rinde, L., Evensen, L., Morelli, V., Hveem, K., Gabrielsen, M., . Hansen, J. (2019). Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism. Journal of Thrombosis and Haemostasis, 17 (8), 1363-1371., which has been published in final form at https://doi.org/10.1111/jth.14493 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Background : Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE). Objectives : To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population. Methods : Cases with a first VTE ( n = 1493) and a subcohort ( n = 13 072) were sampled from the Tromsø study (1994‐2012) and the Nord‐Trøndelag health (HUNT) study (1995‐2008). The DNA samples were genotyped for rs8176719 ( ABO ), rs6025 ( F5 ), rs1799963 ( F2 ), rs2066865 ( FGG ), and rs2036914 ( F11 ). Participants with missing information on risk alleles ( n = 175), FHMI ( n = 2769), and BMI ( n = 52) were excluded. Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) for VTE. To explore the role of prothrombotic genotypes for the association between FHMI and VTE, we (a) included the genotypes in the multivariable‐adjusted models and (b) assessed the joint effects between FHMI and genotypes on VTE risk. Results : The FHMI was associated with a 1.3‐fold increased risk of VTE (HR 1.32, 95% CI 1.16‐1.50) and 1.5‐fold increased risk of unprovoked VTE (HR 1.47, 95% CI 1.22‐1.78). The risk of VTE by FHMI did not alter after adjustment for the five genotypes. The combination of FHMI and the different prothrombotic genotypes did not result in an excess VTE risk (i.e. no biological interaction). Conclusions : Our findings suggest that the risk of VTE by FHMI is not explained by rs8176719 ( ABO ), rs6025 ( F5 ), rs1799963 ( F2 ), rs2066865 ( FGG ), and rs2036914 ( F11 ). The combination of FHMI with prothrombotic genotypes had an additive effect on VTE risk. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Evensen ENVELOPE(-65.617,-65.617,-66.233,-66.233) Tromsø Journal of Thrombosis and Haemostasis 17 8 1363 1371 |
institution |
Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
spellingShingle |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 Småbrekke, Birgit Balteskard Rinde, Ludvig Evensen, Line Holtet Morelli, Vania Maris Hveem, Kristian Gabrielsen, Maiken Elvestad Njølstad, Inger Mathiesen, Ellisiv B. Rosendaal, Frits Richard Brækkan, Sigrid Kufaas Hansen, John-Bjarne Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
topic_facet |
VDP::Medical disciplines: 700 VDP::Medisinske Fag: 700 |
description |
This is the peer reviewed version of the following article: Småbrekke, B., Rinde, L., Evensen, L., Morelli, V., Hveem, K., Gabrielsen, M., . Hansen, J. (2019). Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism. Journal of Thrombosis and Haemostasis, 17 (8), 1363-1371., which has been published in final form at https://doi.org/10.1111/jth.14493 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Background : Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE). Objectives : To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population. Methods : Cases with a first VTE ( n = 1493) and a subcohort ( n = 13 072) were sampled from the Tromsø study (1994‐2012) and the Nord‐Trøndelag health (HUNT) study (1995‐2008). The DNA samples were genotyped for rs8176719 ( ABO ), rs6025 ( F5 ), rs1799963 ( F2 ), rs2066865 ( FGG ), and rs2036914 ( F11 ). Participants with missing information on risk alleles ( n = 175), FHMI ( n = 2769), and BMI ( n = 52) were excluded. Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) for VTE. To explore the role of prothrombotic genotypes for the association between FHMI and VTE, we (a) included the genotypes in the multivariable‐adjusted models and (b) assessed the joint effects between FHMI and genotypes on VTE risk. Results : The FHMI was associated with a 1.3‐fold increased risk of VTE (HR 1.32, 95% CI 1.16‐1.50) and 1.5‐fold increased risk of unprovoked VTE (HR 1.47, 95% CI 1.22‐1.78). The risk of VTE by FHMI did not alter after adjustment for the five genotypes. The combination of FHMI and the different prothrombotic genotypes did not result in an excess VTE risk (i.e. no biological interaction). Conclusions : Our findings suggest that the risk of VTE by FHMI is not explained by rs8176719 ( ABO ), rs6025 ( F5 ), rs1799963 ( F2 ), rs2066865 ( FGG ), and rs2036914 ( F11 ). The combination of FHMI with prothrombotic genotypes had an additive effect on VTE risk. |
format |
Article in Journal/Newspaper |
author |
Småbrekke, Birgit Balteskard Rinde, Ludvig Evensen, Line Holtet Morelli, Vania Maris Hveem, Kristian Gabrielsen, Maiken Elvestad Njølstad, Inger Mathiesen, Ellisiv B. Rosendaal, Frits Richard Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Småbrekke, Birgit Balteskard Rinde, Ludvig Evensen, Line Holtet Morelli, Vania Maris Hveem, Kristian Gabrielsen, Maiken Elvestad Njølstad, Inger Mathiesen, Ellisiv B. Rosendaal, Frits Richard Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Småbrekke, Birgit |
title |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_short |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_full |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_fullStr |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_full_unstemmed |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_sort |
impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
publisher |
Wiley |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/17265 https://doi.org/10.1111/jth.14493 |
long_lat |
ENVELOPE(-65.617,-65.617,-66.233,-66.233) |
geographic |
Evensen Tromsø |
geographic_facet |
Evensen Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Journal of Thrombosis and Haemostasis Stiftelsen Kristian Gerhard Jebsen: SKGJ-MED-015 Norges forskningsråd: 248817 info:eu-repo/grantAgreement/RCN/BEHANDLING/248817/Norway/National training initiative to make better use of biobanks and health registry data// Småbrekke B, Balteskard Rinde LBR, Evensen L, Morelli VM, Hveem K, Gabrielsen ME, Njølstad i, Mathiesen EB, Rosendaal FR, Brækkan SK, Hansen JB. Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism. Journal of Thrombosis and Haemostasis. 2019:1-9 FRIDAID 1700766 doi:10.1111/jth.14493 1538-7933 1538-7836 https://hdl.handle.net/10037/17265 |
op_rights |
openAccess © 2019 International Society on Thrombosis and Haemostasis |
op_doi |
https://doi.org/10.1111/jth.14493 |
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Journal of Thrombosis and Haemostasis |
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17 |
container_issue |
8 |
container_start_page |
1363 |
op_container_end_page |
1371 |
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1766220063744983040 |