Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study
Aims To explore sex-specific associations between long-term individual blood pressure (BP) patterns and risk of incident atrial fibrillation (AF) in the general population. Methods and results Blood pressure was measured in 8376 women and 7670 men who attended at least two of the three population-ba...
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Online Access: | https://hdl.handle.net/10037/16962 https://doi.org/10.1093/eurheartj/ehz234 |
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ftunivtroemsoe:oai:munin.uit.no:10037/16962 2023-05-15T18:34:28+02:00 Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study Sharashova, Ekaterina Wilsgaard, Tom Ball, Jocasta Morseth, Bente Gerdts, Eva Hopstock, Laila Arnesdatter Mathiesen, Ellisiv B. Schirmer, Henrik Løchen, Maja-Lisa 2019-05-03 https://hdl.handle.net/10037/16962 https://doi.org/10.1093/eurheartj/ehz234 eng eng Oxford University Press European Heart Journal Sharashova EE, Wilsgaard T, Ball J, Morseth B, Gerdts E, Hopstock LA, Mathiesen EB, Schirmer H, Løchen M. Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study . European Heart Journal. 2019 FRIDAID 1696231 doi:10.1093/eurheartj/ehz234 0195-668X 1522-9645 https://hdl.handle.net/10037/16962 openAccess Copyright The Author(s). VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Journal article Tidsskriftartikkel Peer reviewed publishedVersion 2019 ftunivtroemsoe https://doi.org/10.1093/eurheartj/ehz234 2021-06-25T17:57:01Z Aims To explore sex-specific associations between long-term individual blood pressure (BP) patterns and risk of incident atrial fibrillation (AF) in the general population. Methods and results Blood pressure was measured in 8376 women and 7670 men who attended at least two of the three population-based Tromsø Study surveys conducted in 1986–87, 1994–95, and 2001. Participants were followed for incident AF throughout 2013. Latent mixed modelling was used to identify long-term trajectories of systolic BP and hypertension. Cox regression was used to estimate associations between the identified trajectories and incident AF. Elevated systolic BP throughout the exposure period (1986–2001) independently and differentially increased risk of AF in women and men. In women, having elevated systolic BP trajectories doubled AF risk compared to having persistently low levels, irrespective of whether systolic BP increased, decreased, or was persistently high over time, with hazard ratios of 1.88 (95% confidence interval 1.37–2.58), 2.32 (1.61–3.35), and 1.94 (1.28–2.94), respectively. In men, those with elevated systolic BP that continued to increase over time had a 50% increased AF risk: 1.51 (1.09–2.10). When compared to those persistently normotensive, women developing hypertension during the exposure period, and women and men with hypertension throughout the exposure period had 1.40 (1.06–1.86), 2.75 (1.99–3.80), and 1.36 (1.10–1.68) times increased risk of AF, respectively. Conclusion Long-term BP and hypertension trajectories were associated with increased incidence of AF in both women and men, but the associations were stronger in women. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø European Heart Journal 41 16 1554 1562 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
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VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Sharashova, Ekaterina Wilsgaard, Tom Ball, Jocasta Morseth, Bente Gerdts, Eva Hopstock, Laila Arnesdatter Mathiesen, Ellisiv B. Schirmer, Henrik Løchen, Maja-Lisa Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
description |
Aims To explore sex-specific associations between long-term individual blood pressure (BP) patterns and risk of incident atrial fibrillation (AF) in the general population. Methods and results Blood pressure was measured in 8376 women and 7670 men who attended at least two of the three population-based Tromsø Study surveys conducted in 1986–87, 1994–95, and 2001. Participants were followed for incident AF throughout 2013. Latent mixed modelling was used to identify long-term trajectories of systolic BP and hypertension. Cox regression was used to estimate associations between the identified trajectories and incident AF. Elevated systolic BP throughout the exposure period (1986–2001) independently and differentially increased risk of AF in women and men. In women, having elevated systolic BP trajectories doubled AF risk compared to having persistently low levels, irrespective of whether systolic BP increased, decreased, or was persistently high over time, with hazard ratios of 1.88 (95% confidence interval 1.37–2.58), 2.32 (1.61–3.35), and 1.94 (1.28–2.94), respectively. In men, those with elevated systolic BP that continued to increase over time had a 50% increased AF risk: 1.51 (1.09–2.10). When compared to those persistently normotensive, women developing hypertension during the exposure period, and women and men with hypertension throughout the exposure period had 1.40 (1.06–1.86), 2.75 (1.99–3.80), and 1.36 (1.10–1.68) times increased risk of AF, respectively. Conclusion Long-term BP and hypertension trajectories were associated with increased incidence of AF in both women and men, but the associations were stronger in women. |
format |
Article in Journal/Newspaper |
author |
Sharashova, Ekaterina Wilsgaard, Tom Ball, Jocasta Morseth, Bente Gerdts, Eva Hopstock, Laila Arnesdatter Mathiesen, Ellisiv B. Schirmer, Henrik Løchen, Maja-Lisa |
author_facet |
Sharashova, Ekaterina Wilsgaard, Tom Ball, Jocasta Morseth, Bente Gerdts, Eva Hopstock, Laila Arnesdatter Mathiesen, Ellisiv B. Schirmer, Henrik Løchen, Maja-Lisa |
author_sort |
Sharashova, Ekaterina |
title |
Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study |
title_short |
Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study |
title_full |
Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study |
title_fullStr |
Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study |
title_full_unstemmed |
Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study |
title_sort |
long-term blood pressure trajectories and incident atrial fibrillation in women and men: the tromsø study |
publisher |
Oxford University Press |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/16962 https://doi.org/10.1093/eurheartj/ehz234 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
European Heart Journal Sharashova EE, Wilsgaard T, Ball J, Morseth B, Gerdts E, Hopstock LA, Mathiesen EB, Schirmer H, Løchen M. Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study . European Heart Journal. 2019 FRIDAID 1696231 doi:10.1093/eurheartj/ehz234 0195-668X 1522-9645 https://hdl.handle.net/10037/16962 |
op_rights |
openAccess Copyright The Author(s). |
op_doi |
https://doi.org/10.1093/eurheartj/ehz234 |
container_title |
European Heart Journal |
container_volume |
41 |
container_issue |
16 |
container_start_page |
1554 |
op_container_end_page |
1562 |
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1766219229890084864 |